3,324 research outputs found
In Vivo Tests of Hybrid Nano Composite Modified Implants
No full textA biomimetic approach has been applied to design and realize new odontostomatological Titanium (Ti) implants using a multifunctional bioactive ceramo-polymeric hybrid material. The proposed biomimetic/biomechanical approach consists in combining mechanical and physical characterization of the hybrid nanocomposite to biosolid mechanics Finite Element Analysis of the new design implants. Hybrid ceramo-polymeric nanocomposites based on Hydroxyl-Ethyl-Methacrylate polymer (pHEMA) filled with nanosilica particles are presented as biomimetic-scaffolding materials. Cytotoxicity and Osteoblast cells adhesion tests have shown good material biocompatibility and osteoconductivity [1]. Dynamic Mechanical Analysis (DMA) confirmed the hybrid mechanical behaviour of these nanocomposites. Moreover, this class of material swells in presence of aqueous physiological solution according to limiting Case II sorption mode turning from glassy and rigid to soft and rubbery while presenting a mechanical behaviour, at 5 to 10 % nanosilica volume loadings, that is comparable with that of bone (when glassy) and to that of the cartilage and Ligaments (when rubbery).
The use of mechanically compatible hybrid hydrogels as scaffolding materials are expected to increase prosthesis adaptation mechanisms introducing active interfaces that improve implant biomimetics while reproducing cartilage and ligaments biomechanical functions.
[1] C Schiraldi, A D'Agostino, A Oliva, ... R Aversa, M De Rosa, Biomaterials, 25 (17), 3645-3653 (2004).
[2] R Aversa, D Apicella, L Perillo, R Sorrentino, F Zarone, M Ferrari, A Apicella, Dental Materials, 25(5), 678-690 (2009).
[3] D Apicella, R Aversa, F Ferro, D Ianniello, A Apicella, J. of Biomedical Material Research: Part B, Applied Biomaterials, vol-93(1), 150-163 (2010)
Uma história do ensino primário em tempos de modernização da matemática escolar, Vassouras, 1950-1969.
No full textSALVADOR, Heloisa Hernandez de Fontes. Uma história do ensino primário em tempos de modernização, Vassouras 1950-1969, 2012, xv, 104f.: il.; 29,7cm. Dissertação (Mestrado Profissional em Educação Matemática) – Universidade Severino Sombra, Vassouras, 2012.A presente dissertação está inserida no projeto “A Matemática do Ensino Primário de Vassouras, RJ: Estudando um século de provas de alunos (1869 – 1969)”, financiado pela FAPERJ, coordenado pela professora Lúcia Maria Aversa Villela. Baseou-se no aporte teórico-metodológico da História Cultural e, como indica o título, localiza parte da história da educação matemática, em um espaço geográfico – Vassouras, cidade histórica localizada na região centro-sul fluminense – no período de 1950 a 1969. Teve como objetivo geral analisar as transformações sofridas pelo ensino da matemática no curso primário, neste espaço temporal, a partir de provas de alunos encontradas no Arquivo Público da Secretaria Municipal de Educação de Vassouras (APSMEV), sob a salvaguarda da seção do Instituto de Pesquisa Histórica do Arquivo Nacional (IPHAN). Estas fontes foram cotejadas com livros didáticos, que segundo indícios, provavelmente foram utilizados pelos professores do município nesta época, além de legislações, depoimentos orais e outros dados. A pesquisa mostra que o ensino primário de Vassouras neste período apresentava uma diversidade quanto às metodologias utilizadas, percebendo-se a presença do modelo tradicional caracterizado pelo ensino intuitivo ou lição das coisas e o ensino baseado nas experiências das crianças que tem a Escola Nova como precursora. Por estar vinculada a linha de pesquisa História da Educação Matemática do Mestrado Profissional em Educação Matemática, a presente pesquisa disponibiliza como produto um livreto - “Dividindo histórias e opiniões- Compartilhando e polemizando a operação de divisão” - que partilha “histórias” sobre a operação de divisão, encontradas nos livros didáticos analisados durante a pesquisa, além de alguns de Arithmetica do século XIX e de História da Matemática
Biomechanically Active Hybrid nano composite for early osteointegration implants
No full textA biomimetic approach has been applied to design and realize new odontostomatological Titanium (Ti) implants using a multifunctional bioactive ceramopolymeric hybrid material. The proposed biomimetic/biomechanical approach consists in combining mechanical and physical characterization of the hybrid nanocomposite to biosolid mechanics Finite Element Analysis of the new design implants. Hybrid ceramopolymeric nanocomposites based on Hydroxyl-Ethyl-Methacrylate polymer (pHEMA) filled with nanosilica particles are presented as biomimetic-scaffolding materials. Cytotoxicity and Osteoblast cells adhesion tests have shown good material biocompatibility and osteoconductivity [1]. Dynamic Mechanical Analysis (DMA) confirmed the hybrid mechanical behaviour of these nanocomposites. Moreover, this class of material swells in presence of aqueous physiological solution according to limiting Case II sorption mode turning from glassy and rigid to soft and rubbery while presenting a mechanical behaviour, at 5 to 10 % nanosilica volume loadings, that is comparable with that of bone (when glassy) and to that of the cartilage and Ligaments (when rubbery). Materials swelling behaviour and mechanical characterizations are presented. Design criteria and FEM simulation are discussed. The use of mechanically compatible hybrid hydrogels as scaffolding materials are expected to increase prosthesis adaptation mechanisms introducing active interfaces that improve implant biomimetics while reproducing cartilage and ligaments biomechanical functions.
[1] C Schiraldi, A D'Agostino, A Oliva, ... R Aversa, M De Rosa, Biomaterials, 25 (17), 3645-3653 (2004).
[2] R Aversa, D Apicella, L Perillo, R Sorrentino, F Zarone, M Ferrari, A Apicella, Dental Materials, 25(5), 678-690 (2009).
[3] D Apicella, R Aversa, F Ferro, D Ianniello, A Apicella, J. of Biomedical Material Research: Part B, Applied Biomaterials, vol-93(1), 150-163 (2010)
Peculiarità del paziente pediatrico. In “Profilassi delle Infezioni Fungine”.
No full textMonografia sulle caratteristiche delle infezioni fungine nel paziente pediatrico oncoematologic
Hybrid Ceramo-Polymeric Scaffolds with Biomimetic Characteristics
No full textThe research develops and tests new hybrid biomimetic materials that work as mechanically stimulating "scaffolds" to promote early regeneration in implanted bone healing phases. A biomimetic nanostructured osteoconductive material coated apparatus is presented. Bioinspired approaches to materials and templated growth of hybrid networks using self-assembled hybrid organic-inorganic interfaces is finalized to extend the use of hybrids in the medical field. Combined in vivo, in vitro and computeraided simulations have been carried out. A new experimental methodology for the identification of design criteria for new innovative prosthetic implant systems is presented. The new implant design minimizes the invasiveness of treatments while improving implant functional integration [1]. A new bioactive ceramo-polymeric hybrid material was used to modify odontostomatological Titanium implants in order to promote early fixation, biomechanical stimulation for improved scaffold mineralization and ossification. It is a hybrid ceramo-polymeric nanocomposites based on Hydroxyl-Ethyl- Methacrylate polymer (pHEMA) filled with nanosilica particles that have shown biomimetic characteristics [2,3]. This material swells in presence of aqueous physiological solution leading to the achievement of two biomechanical functions: prosthesis early fixation after and bone growth stimulation. Such multidisciplinary approach explores novel ideas in modelling, design and fabrication of new nanostructured biomaterials with enhanced functionality and improved interaction with OB cells.
[1] R Aversa, D Apicella, L Perillo, R Sorrentino, F Zarone, M Ferrari, A Apicella, Dental Materials, 25(5), 678-690 (2009).
[2] C Schiraldi, A D'Agostino, A Oliva, ... R Aversa, M De Rosa, Biomaterials, 25 (17), 3645-3653 (2004).
[3] G R. Beck, Shin-Woo Ha, C E Camalier, M Yamaguchi, Y Li, J K Lee, M. N Weitzmann, Nanomedicine, 8(6), 793-803 (2012)
VisuaLies: Towards a Classification of Misinfovis Situations
No full textThis paper presents VisuaLies, a workshop designed to engage citizens in identifying misleading information visualisations (Misinfovis). The workshop aims to validate and enhance the Classification of Misinfovis Situations (CMiS), a classification system for lay citizens to spot the formal characteristics of Misinfovis, which we call ‘Misinfovis Situations’. Conducted with participants of varying educational backgrounds, VisuaLies included activities to assess pre-existing knowledge, familiarise with Misinfovis concepts, classify Misinfovis examples and lead to an updated version of CMiS featuring fewer Situations with more accessible language. This study underscores the importance of involving lay people in recognising and describing Misinfovis with their own words to support the development of inclusive knowledge societies. Future iterations of VisuaLies aim to involve diverse audiences and refine feedback collection methods to further enhance the classification’s effectiveness
NK cell alloreactivity and allogeneic hematopoietic stem cell transplantation.
No full textAs only 60% of leukaemia patients find a matched donor, the Perugia Bone Marrow Transplant Centre developed transplantation from HLA haplotype-mismatched family donors to provide a cure for more patients [F. Aversa, A. Tabilio, A. Terenzi, et al., Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum, Blood 84 (1994) 3948-3955] [F. Aversa, A. Tabilio, A. Velardi, et al., Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype, N. Engl. J. Med. 339 (1998) 1186-1193] [F. Aversa, A. Terenzi, A. Tabilio, et al., Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse, J. Clin. Oncol. 23 (2005) 3447-3454]. HLA-mismatches trigger donor vs. recipient NK cell alloreactivity which improves engraftment, protects from GvHD and reduces relapse in AML patients [L. Ruggeri, M. Capanni, E. Urbani, et al., Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants, Science 295 (2002) 2097-2100], [L. Ruggeri, A. Mancusi, M. Capanni, E. Urbani, A. Carotti, T. Aloisi, M. Stern, D. Pende, K. Perruccio, E. Burchielli, F. Topini, E. Bianchi, F. Aversa, M.F. Martelli, A. Velardi, Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value, Blood, in press]. We are using murine transplant models to determine whether NK cell alloreactivity can be exploited to reduce transplant-related mortality (TRM) which remains a major issue. Data from these on-going studies show pre-transplant infusion of alloreactive NK cells: (1) ablates AML cells, (2) kills recipient T cells, permitting a reduced toxicity conditioning regimen, and (3) ablates the recipient dendritic cells (DCs) which trigger GvHD, thus protecting from GvHD while permitting a higher T cell content in the graft. We are designing a clinical haploidentical transplant trial using alloreactive NK cells in the conditioning regimen, with the aim of reducing TRM and improving outcomes and overall survival
Lifestyle and Osteoporosis Risk in Men (Physical Activity, Diet, Alcohol Abuse)
No full textMale osteoporosis is a health problem of multifactorial origin. Bone mineral density evaluation (BMD) by X-ray densitometry allows diagnosis, while stratification of risk fracture is usually done through useful diagnostic tools (i.e., FRAXc). The risk of osteoporotic fracture results from a combination of modifiable and unmodifiable factors. Lifestyle factors are the modifiable factors that can greatly impact on overall health and well-being, including bone health. Many lifestyle factors such as physical activity, diet, alcohol abuse, and smoking can have substantial effects on bone metabolism. Nowadays, the crucial role that lifestyle factors play in the development of male osteoporosis has generated a growing interest in this field of study. Male osteoporosis prevention (or non-pharmacological intervention) should be based on the elimination of specific modifiable risk factors (alcohol abuse, smoking, environmental risk factors for falls, etc.) by means of regular physical activity and an adequate nutritional supply of calcium and vitamin D. Non-pharmacological interventions for the prevention and treatment of osteoporosis are recommended for all subjects
CAG repeat testing of androgen receptor polymorphism: is this necessary for the best clinical management of hypogonadism?
No full textIntroduction It is controversial whether or not testing the length of the androgen receptor polymorphism in clinical practice is useful for correct diagnosis and treatment of hypogonadism. AimTo describe the molecular and clinical implications of testing the length of the androgen receptor polymorphism for treatment of hypogonadism in both male and female subjects. MethodsA systematic Medline search was conducted using several terms related to and including the terms androgen receptor, CAG-repeat polymorphism, male hypogonadism, female hypogonadism, and neurodegenerative disease. Main Outcome MeasuresClinical evidence that demonstrates the importance of CAG repeat number investigation in male and female hypogonadism. Results A thorough review of the clinical utility of CAG repeat polymorphism investigation in men and women with hypogonadism is presented. Conclusions The role of AR CAG repeat number investigation in hypogonadism (male and female) is not yet established in the clinical practice. In both sexes, a role during clinical management of hormonal replacement therapies may be hypothesized, but the CAG repeat number's relationship with the presence or absence of hypogonadal symptoms remains unclear. Pharmacogenomic investigations of the AR polymorphism may be a future option to tailor testosterone titration individually and to better identify subjects as potentially more or less responsive to treatments; also, investigation may be important to individually predict beneficial and side effects in special subpopulations, specifically, obese men and postmenopausal women. Francomano D, Greco EA, Lenzi A, and Aversa A. CAG repeat testing of androgen receptor polymorphism: Is this necessary for the best clinical management of hypogonadism? J Sex Med 2013;10:2373-2381
The therapeutic dilemma: how to use short-acting PDE5 inhibitor drugs
No full textIn the last few years, the clinical context of the diagnosis and treatment of erectile dysfunction (ED) has changed radically. In fact, oral drug treatment with phosphodiesterase type-5 inhibitors (PDE5-i), licensed in the past years, appeared to offer advantages over other medical approaches in terms of ease of administration and cost. PDE5-i are now widely advocated as first-line therapy for ED. PDE5-i represent a class of orally active drugs for ED, which inhibit PDE5 enzyme and in turn enhance smooth muscle relaxation via prolongation of cyclic GMP action within the cavernous smooth muscle. Although the various types of PDE5-i differ with respect to selectivity and pharmacokinetic profiles, efficacy and safety of these agents are mostly comparable in broad populations of men with erectile ED, including those with diabetes, cardiovascular disease or those taking multiple antihypertensive agents. Aim of this article will be to review the different efficacy and safety profiles of oral short-acting compounds and to give indication for treatment of special populations of men with ED
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