7,313 research outputs found
Orvid Heil Interview
No full textOrvid Heil was born on November 9, 1910 in Toledo. He was the founder of the Heil Sign Company, and later purchased the Toledo Sign Company. He was a master goldleaf painter and painted many downtown office doors. He was a member of the Toledo Sign Contactors Association, North Toledo Oldtimer's Association, and the Toledo Museum of Art. He and his wife Martha had been married for 54 years. He died in Toledo on December 17, 1993 at the age of 83
Role of working memory load on selective attention to affectively valent information
No full textEmpirical evidence obtained with neutral stimuli has shown that selective attention relies on working memory functions as distractor processing occurs under conditions of high but not of low working memory load. We investigated whether these findings also hold for affectively valent distractors. In three experiments, participants completed the original Flanker task with famous people (Exps 1 and 2) and an affective Flanker task (Exp. 3) in which positive and negative words were presented superimposed onto happy, angry, and neutral faces under conditions of high or low working memory load. In line with past findings, results showed greater interference effects due to processing of distractors showing known people under high working memory load. In contrast interference effects due to processing of valent distractors occurred regardless of working memory load. The present findings are in contrast with those reported with neutral stimuli as they indicate that automatic evaluation of incoming affectively valent information occurs regardless of task priorities and of working memory load
Unterkunftshaus a. Brünnstein, Pächter B. Brenner, Rodel Heil!
No full textUNTERKUNFTSHAUS A. BRÜNNSTEIN, PÄCHTER B. BRENNER, RODEL HEIL!
Unterkunftshaus a. Brünnstein, Pächter B. Brenner, Rodel Heil! ( -
The impact of scale on children’s spatial thought: a quantitative study for two settings in geometry education
No full textIn this book, Cathleen Heil addresses the question of how to conceptually understand children’s spatial thought in the context of geometry education. She proposes that in order to help children develop their abilities to successfully grasp and manipulate the spatial relations they experience in their everyday lives, spatial thought should not only be addressed in written or tabletop settings at school. Instead, geometry education should also focus on settings involving real space, such as during reasoning with maps. In a first part of this book, she theoretically addresses the construct of spatial thought at different scales of space from a cognitive psychological point of view and shows that maps can be rich sources for spatial thinking. In a second part, she proposes how to measure children’s spatial thought in a paper-and-pencil setting and map-based setting in real space. In a third, empirical part, she examines the relations between children’s spatial thought in those two settings both at a manifest and latent level. About the author Cathleen Heil is a research assistant at the Institute of Mathematics and its Didactics at Leuphana University Lüneburg. She received her PhD under supervision of Prof. Dr. Silke Ruwisch. She is currently a fellow of Deutsche Telekom Stiftung, examining how learning environments involving maps may improve children‘s spatial thought in geometry education
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Publications of the Institute of Marine Science
No full textTable of Contents. Florida Bay: A subtropical system increasingly influenced by multiple stressors / P.M. Glibert, C.A. Heil and C.J. Madden (p. 1-4) -- Florida Bay: Water quality status and trends, historic and emerging algal bloom problems / P.M. Glibert, C.A. Heil, D.T. Rudnick, C.J. Madden, J.N. Boyer and S.P. Kelly (p. 5-18) -- Physiological characteristics and competitive strategies of bloom-forming cyanobacteria and diatoms of Florida Bay / B. Richardson (p. 19-36) -- Size-fractionated alkaline phosphatase activity along a gradient of nitrogen to phosphorous limitation in a carbonate dominated subtropical estuary / C.A. Heil, P.M. Glibert, S. Murasko and J. Alexander (p. 37-48) -- Water column nitrogen cycling and microbial plankton in Florida Bay / M.J. McCarthy, W.S. Gardner, P.J. Lavrentyev, F.J. Jochem and C.J. Williams (p. 49-62) -- Estimates of phytoplankton growth from a Lagrangian experiment in western Florida Bay, USA / G.A. Vargo, G.L. Hitchcock and M.B. Neely (p. 63-72) -- Comparative nutrient and phytoplankton dynamics in two subtropical estuaries: Florida Bay, USA and Moreton Bay, Australia / P.M. Glibert, C.A. Heil, J. Alexander, S. Murasko and J.M. O'Neil (p. 73-90) -- Seasonal and regional variation in net ecosystem production in Thalassia testudinum, communities throughout Florida Bay / J.L. Nagel, W.M. Kemp, J.C. Cornwell, M.S. Owens, D. Hinkle and C.J. Madden (p. 91-108) -- Carbon (δ13C) and nitrogen (δ15N) isotopic discrimination in mangroves in Florida coastal Everglades as a function of environmental stress / J.E. Mancera-Pineda, R.T. Twilley and V.H. Rivera-Monroy (p. 109-129)UT Librarie
The doubly inelastic contribution to electron loss: H0 and He0 (0,5 MeV u-1) in collision with Ar
No full textOne size does not fit all: Cell type specific tailoring of culture conditions permits establishment of divergent stable lines from murine cerebellum
No full textLo studio in vitro dei progenitori neurali si basa sul concetto che, delle condizioni di coltura cellulare, siano capaci di emulare un ambiente che mantiene uno stato non-differenziato e di autorinnovamento cellulare. Ciò porta alla crescità di neurosfere. Sonic hedgehog (SHH) rappresenta una via di segnalazione chiave sia nel contesto della morfogenesi che nella proliferazione cellulare a livello del sistema nervoso centrale. In particolare, SHH e coinvolto nella segnalazione mitogenica post-natale dei progenitori granulari del cereveletto (GCP).
Oltre ai mitogeni communemente usati (EGF e bFGF), dimostriamo che sia il trattamento con SAG, un agonista della via di SHH, che l’attivazione genetica della via SHH tramite delezione del gene PTCH1, portano alla crescità di neurosfere, a partire da espianti di cereveletto all’età di 7 giorni postnatale (p7). Oltremodo, SAG puo indurre la formazione di neurosfere, chiamate sfere SAG dipendente murine (mSS), solo partendo da tessuto cerebellare p7 e non dalla zona sub-ventricolare (SVZ), generalmente nota come fonte di cellule che danno origine alle neurosfere.
Inoltre, le colture mSS esprimono ZIC1, ATOH1 e NESTIN, suggerendone l’identità di granuli cerebellari. Notevolmente, rispetto al noto comportamento delle cellule GCP, le cellule mSS possono essere mantenute in colture per tempi indefiniti, come misurato attraverso il saggio di clonogenicità, applicato per un periodo di 10 settimane.
Nel contesto dell autorinnovamento confermiamo inoltre l’espressione dei geni POU3f2, POU5f1, NANOG e SOX2 nelle cellule mSS, che sono comunemente associati ai progenitori neuronali. Rilevantemente, le cellule mSS, per essere clonogeniche e per mantenere l’attività della via SHH, misurata in termini di espressione di GLI1, PTCH1 e NMYC, rimangono dipendenti dal SAG.
Oltre a mantenere la capacita di autorinnovamento, le colture mSS mantengono anche la capacità di differenziamento. Il differenziamento in vitro porta alla formazione di cellule con morfologia tipica delle cellule granulari del cereveletto che dimostrano positività per tubulina beta-3, misurato sia per western blot che per immunofluorescenza. Inoltre, durante il differenziamento le cellule mSS aumentano l’espressione di GABRA6, un marcatore del differenziamento delle cellule GCP.
Questo lavoro e la dimostrazione che si può confezionare su misura un protocollo di coltura cellulare capace di espandere cellule progenitrici da particolari zone del sistema nervoso centrale. Questo permette di estendere il concetto di neurosfera a cellule che non sono state considerate tali fino ad ora. In particolare, estendiamo questo concetto alle cellule GCP rivelando la loro capacità
di estensivo autorinnovamento in vitro.The in vitro study of neural progenitors is based around the idea that defined culture conditions can
emulate an environment which maintains an undifferentiated state and self-renewal capability of
explanted progenitor cells, culminating in the growth of neurospheres. SHH signaling is a key
signaling pathway with roles in morphogenesis and cell proliferation in the central nervous system, in
particular, involved in mitogenic signaling within the context of postnatal cerebellar granule cell
expansion. We demonstrate that in addition to commonly used mitogens such as EGF and bFGF, the
SHH pathway agonist SAG, as well as genetic activation of SHH signaling by PTCH1 deletion, can lead
to the growth of neurospheres from postnatal day 7 (p7) cerebellar explants. Interestingly, SAG
derived cultures, termed murine SAG dependent spheres (mSS), can be generated solely from the p7
cerebellum and not from the sub-ventricular zone, a confirmed source of neurospheres derived by
growth factors. Further, mSS cultures expressed ZIC1, ATOH1 and NESTIN, indicating that their
identity is of the cerebellar granule cell progenitor (GCP) lineage. Strikingly, mSS cells can be
maintained indefinitely in culture, as demonstrated by extensive clonogenic capability, assayed over
a period of ten weeks. In the context of self-renewal, we assay gene expression of POU3f2, POU5f1,
NANOG, and SOX2, genes associated with neural progenitors, which we find expressed in mSS cells.
Importantly, mSS cultures are continuously dependent on SAG for their clonogenic potential and SHH
pathway activation, assayed by expression of GLI1, PTCH1 and NMYC. In addition to the
aforementioned extensive self-renewal capability mSS neurosphere cultures also maintain the ability
to differentiate. In vitro differentiation leads to formation of cells with typical granule cell
morphology and which are positive for beta3-tubulin, as assayed by western blot and
immunofluorescence. Additionally, differentiated mSS cells display up-regulation of the cerebellar
granule expressed gene GABRA6. Our work demonstrates that by applying culture conditions which
are tailored towards biological characteristics of specific regions of the central nervous system the
paradigm of the neurosphere can be expanded to include lineages not previously studied in this way.
In particular, we apply this principle to unmask the property of cells from the GCP lineage as having
extensive self-renewal capability in vitro
A wise doorman’s hidden treasures
No full textMaintaining one’s reputation is a central concern in Latin American cities, and the doormen of buildings have a crucial part to play. Tilmann Heil delves deeper into the intricate dynamics of Rio de Janeiro’s entry halls and highlights how they operate as urban microcosms in which reputation, security and care materialize across structural inequality
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