64 research outputs found
PEMANFAATAN MALTODEKSTRIN DARI PATI SINGKONG SEBAGAI BAHAN PENYALUT LAPIS TIPIS TABLET
Get PDFThe Use of Maltodextrin from Tapioca Starch as a Film Coating Tablet Material. Maltodexrin is a modifi ed starch product which can be use as a material fi lm coating tablet. The aim of the research was to study the capability of maltodextrin as a material fi lm coating exipient. Maltodextrin DE 5-10 was made by hidrolysis of tapioca starch with α-amylase enzyme from NOVO (Termamyl L120®), at 80° C, for 65 minute. Maltodextrin was used as a fi lm coating material at concentration 10%,15%,20% dan 25%. As a comparative fi lm coating material was used HPMC. The evaluation of the coating tablet was done accordance to Farmacope Indonesia third and fourth edition. The result show that maltodextrin DE 5-10 from tapioca starch can be used as fi lm coating at concentration 10-25% with concentration 10% gave better result a HPM
FORMULATION AND EVALUATION OF COSMETIC FOUNDATION USING EPIGALLOCATECHIN GALLATE AS A SUN PROTECTION
Get PDFObjective: The objective of the study was to obtain a lotion foundation using epigallocatechin gallate (EGCG) as an active ingredient designed with asun protection factor (SPF) value around 30 that can effectively protect facial skin from ultraviolet radiation (UVR) exposure and that is safe to use.Methods: In this study, we determine SPF value using UV–visible spectrophotometry at a wavelength between 290 and 320 nm. The preparationformula of the foundation was made with an EGCG concentration of 0.4%, a concentration which can yield the desired SPF value of about 30. Physicalstability was performed at low (4±2°C), ambient (25±2°C), and high (40±2°C) temperatures; cycling and centrifugation tests were also conducted.Safety was evaluated by eye irritation test using hen’s egg test on chorioallantois method and skin irritation test using the Draize and patch testsmethod.Results: The SPF values of 0.04% EGCG and lotion foundation containing 0.4% EGCG were 31.02±0.72 and 33.20±0.59, respectively. The results ofcycling and centrifugal tests indicated that lotion foundation showed an absence of crystals and lack of any phase separation between oil and waterphases. The physical stability test showed no significant changes for all parameters. Safety tests resulted in neither skin nor eye irritation.Conclusion: The EGCG foundation developed was physically stable with a good appearance and did not irritate the skin or eyes thus are safe to usealso can effectively protect skin against UVR exposure
Pemanfaatan Maltodekstrin Dari Pati Singkong Sebagai Bahan Penyalut Lapis Tipis Tablet
No full textThe Use of Maltodextrin from Tapioca Starch as a Film Coating Tablet Material. Maltodexrin is a modifi ed starch productwhich can be use as a material fi lm coating tablet. The aim of the research was to study the capability of maltodextrin asa material fi lm coating exipient. Maltodextrin DE 5-10 was made by hidrolysis of tapioca starch with α-amylase enzymefrom NOVO (Termamyl L120®), at 80° C, for 65 minute. Maltodextrin was used as a fi lm coating material at concentration10%,15%,20% dan 25%. As a comparative fi lm coating material was used HPMC. The evaluation of the coating tabletwas done accordance to Farmacope Indonesia third and fourth edition. The result show that maltodextrin DE 5-10 fromtapioca starch can be used as fi lm coating at concentration 10-25% with concentration 10% gave better result a HPMC
PREPARATION AND CHARACTERIZATION OF CO-PROCESSED EXCIPIENT-PREGELATINIZED CASSAVA STARCH PROPIONATE AS A MATRIX IN THE GASTRORETENTIVE DOSAGE FORM
No full textThe gastroretentive dosage form is designed to prolong the gastric residence time of the drug delivery system whichalso results in the development of an appropriate excipient. The purpose of this study is to develop and characterize coprocessedexcipient made from carrageenan (kappa-iota = 1:1) and pregelatinized cassava starch propionate (PCSP) inratios of 1:1, 1:2, and 1:3. PCSP was prepared with propionic anhydride in an aqueous medium. The product was mixedwith carrageenan (kappa-iota = 1:1), as well as characterized physicochemical and functional properties. The coprocessedexcipient was then used as a mucoadhesive granule and floating tablet. The USP Basket was selected toperform the dissolution test of the granules in HCl buffer (pH 1.2) and distilled water for 8 hours each. Mucoadhesiveproperties were evaluated using bioadhesive through a vitro test and wash-off test. As for the floating tablet, the USPPaddle was selected to perform the dissolution test of the tablets in 0.1 N HCl for 10 hours. The floating lag time andfloating time were tested in 0.1 N HCl for 24 hours. The result of these studies indicated that co-processed excipientcarrageenan-PCSP can retard dosage form in gastric and drug controlled release, thus making it a suitable material forthe gastroretentive dosage form
Succinylated soybean protein as novel excipient for matrix sustained release microspheres
No full textKandungan Senyawa Penangkal Sinar Ultra Violet dari Ekstrak Rumput Laut Eucheuma cottonii dan Turbinaria conoides
Get PDFRumput laut memiliki beberapa aplikasi ekonomi dalam berbagai jenis industri, salah satunya untuk industri kosmetik. Salah satu kosmetik yang banyak digunakan yaitu krim tabir surya. Efektivitas dari krim tabir surya biasanya dinyatakan dengan nilai SPF (sun protection factor). Tujuan dari penelitian ini adalah untuk mengetahui kandungan senyawa aktif dan nilai SPF pada ekstrak rumput laut Turbinaria conoides dan Eucheuma cottonii yang dapat digunakan sebagai bahan aktif pada sediaan krim tabir surya. Hasil pengujian menunjukkan rumput laut Turbinaria conoides mengandung golongan senyawa fenol hidrokuinon, flavonoid, triterpenoid, steroid, dan saponin. Rumput laut Eucheuma cottonii hanya ditemukan senyawa alkaloid. Nilai SPF tertinggi pada rumput laut Turbinaria conoides terdapat pada ekstrak metanol (SPF 16.7), sedangkan untuk rumput laut Eucheuma cottonii terdapat pada ekstrak etil asetat (SPF 8.8). Hasil tersebut memperlihatkan bahwa ekstrak dari rumput laut Turbinaria conoides dan Eucheuma cottonii memiliki potensi yang baik jika digunakan sebagai bahan aktif pada sediaan krim tabir surya. </jats:p
FORMULATION OF A FAST-DISINTEGRATING TABLET USING MALTODEXTRIN DE 10-15 AND PREGELATINIZATED CASSAVA STARCH AS EXPEDIENTS
Get PDFObjective: Fast-disintegrating tablets are a pharmaceutical preparation that is rapidly being developed because they can dissolve in the oral cavitywithout chewing and without additional water support. The type of dissolver is a crucial component in fast-disintegrating tablets. Maltodextrin andpregelatinized cassava starch (PPS) are excipients that can be used as dissolvers. This study aimed to formulate fast-disintegrating tablets using acombination of maltodextrin dextrose equivalent (DE) 10-15 and PPS in various concentrations as excipients.Methods: The cassava starch classified as PPS was obtained. PPS was then mixed with maltodextrin DE 10-15 to create fast-disintegrating tabletsusing the wet granulation method.Results: Tablet evaluation showed that formula F containing 40% maltodextrin DE 10-15 and 10% PPS was the most effective of the proposed fastdisintegratingtablets.Conclusions: Formula F has a hardness of 3.39 kp, 0.74% friability, a wetting time of 7.87 seconds, and a dissolve time of 38.55 seconds.</jats:p
FORMULATION AND DISSOLUTION PROFILE STUDY OF TRANSFERSOME-LOADED MICROSPHERES FROM GREEN TEA LEAF EXTRACT
Get PDFObjective: The aim of this study was to prepare transfersome-loaded microspheres which had good characteristics and physicochemical stability toincrease bioavailability of the polyphenol component of green tea leaf extract in the body.Methods: Transfersomes were prepared using a thin-layer hydration method. Green tea leaf extract transfersomes were formulated in the ratio of95:5, 90:10, and 85:15 based on their phospholipid and Span 80 content.Results: The most successful formula produced transfersomes of a spherical shape, 78.75 nm in size with a polydispersity index of 0.187, zetapotential of −37.5 mV, and entrapment efficiency of 47.96±5.81%. Subsequently, the transfersome was loaded into a microsphere using the spray-drymethod. The microspheres had a non-spherical, wrinkled shape, their size was 2058.44 nm, their polydispersity index was 0.545, their entrapmentefficiency was 59.27±0.59%, their moisture content was 5.21%, and their swelling index was 289.36% after 4 h. The total cumulative amount ofEpigallocatechin-3-gallate after a dissolution test was 69.15±7.66%.Conclusion: The physicochemical stability of transfersome-loaded microspheres was not significantly different from that of transfersome powder
TRANSFERSOME GEL FORMULATION OF AN ETHANOL EXTRACT OF APPLES (MALUS DOMESTICA MILL) CONTAINING ANTIOXIDANTS AND IN VITRO PENETRATION TESTING USING FRANZ DIFFUSION CELLS
No full textObjective: This study aims to formulate and characterize a transfersome apple peel extract, formulate it into a gel, and compare it with a control gelmade without transfersome.Methods: Both gels were evaluated, stability tested, and penetration tested using Franz diffusion cells on the skin of female Sprague-Dawley rats. Thetransfersome preparations were formulated with different concentrations of the active substance, quercetin: 0.5% (F1); 0.7% (F2), and 1.0% (F3).Results: Based on the characterization results, F1 was selected as the optimum gel formulation because it had spherical morphology, a Dmean volume of106.44±2.70 nm, a polydispersity index of 0.078±0.01, a zeta potential of −49.96±2.05 mV, and a drug efficiency entrapment percentage of 78.78±0.46%.The cumulative amount of quercetin that was penetrated with the transfersome gel was 1514.41±26.31 μg/cm2, whereas the penetration with thecontrol gel extract was 1133.62±18.96 μg/cm2. The cumulative percentages of the penetrated gel transfersome and gel extract were 78.40±1.89%and 49.89±0.88%, respectively. The fluxes of transfersome gel and control gel extract were 52.33±0.11 μg/cm²/hrs and 40.89±0.68 μg/cm²/hrs,respectively.Conclusions: Based on these results, it can be concluded that the gel with transfersome exhibited better penetration than the gel extract alone.</jats:p
FORMULATION OF A CREAM CONTAINING ETHOSOMAL GREEN TEA (CAMELLIA SINENSIS L. KUNTZE) LEAF EXTRACTS FOR IMPROVED DERMAL PENETRATION
Get PDFObjective: This study aimed to formulate the epigallocatechin gallate (EGCG) from green tea into ethosomes and measure the resulting increases inskin penetration using a rat model.Methods: Ethosomes were formulated using ethanol concentrations of 25% (F1), 30% (F2), and 35% (F3), and those with favorable characteristicswere then incorporated into a cream for the determination of penetration into Franz diffusion cells.Results: We showed that the formulation F3 had the best spherical morphology, a Z-average value of 73.01 nm, a polydispersity index of 0.26, azeta potential of −47.77±3.93 mV, and the highest percentage of drug entrapment (49.46%±0.62%) compared with the other formulas. The totalcumulative EGCG penetration from the resulting ethosomal cream was 905.75±49.47 μg/cm2, whereas that from the cream containing green tea leafextract was only 413.92±52.83 μg/cm2.Conclusion: These data indicate a higher penetration of EGCG from ethosomal green tea cream than from cream containing non-ethosomal green teaextract
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