1,723,486 research outputs found
Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway
No full textKiran Kumar Soni,1,* Yu Seob Shin,1,* Bo Ram Choi,1 Keshab Kumar Karna,1 Hye Kyung Kim,2 Sung Won Lee,3 Chul Young Kim,4 Jong Kwan Park1 1Department of Urology, Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University, Jeonju, 2College of Pharmacy, Kyungsung University, Busan, 3Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University Medical School, Seoul, 4College of Pharmacy, Hangyang University, Ansan, Republic of Korea *These authors contributed equally to this work Abstract: Finasteride is used to treat male pattern baldness and benign prostatic hyperplasia. This study investigated the toxicity of finasteride and recovery by DA-9401 using Sprague Dawley (SD) rats. Forty adult male SD rats were assigned to four groups: control (CTR), finasteride 1 mg/kg/day (F), finasteride 1 mg/kg + DA-9401 100 mg/kg/day (F + DA 100) and finasteride 1 mg/kg + DA-9401 200 mg/kg/day (F + DA 200). Treatments were by oral delivery once daily for 90 consecutive days. The gross anatomical parameters assessed included: genital organ weight; vas deferens sperm count and sperm motility; testosterone, dihydrotestosterone (DHT) and malondialdehyde levels; and histological and terminal deoxynucleotidyl transferase enzyme mediated dUTP nick-end labeling (TUNEL) staining of testis for spermatogenic cell density, Johnsen’s score and apoptosis. Testicular tissue was also used for evaluating endoplasmic reticulum (ER) stress and apoptotic proteins. Epididymis weight, seminal vesicle weight, prostate weight, penile weight and vas deferens sperm motility showed significant differences between the F group and the CTR, F + DA 100 and F + DA 200 groups. There was no significant change in the testosterone level. DHT level decreased significantly in the F group compared with the CTR group. Testis tissue revealed significant changes in spermatogenic cell density, Johnsen’s score and apoptotic index. Western blot showed significant changes in the ER stress and apoptotic markers. Finasteride resulted in reduced fertility and increased ER stress and apoptotic markers, which were recovered by administration of DA-9401 in the SD rats. Keywords: finasteride, DA-9401, infertility, sperm, dihydrotestosterone, endoplasmic reticulum stress, apoptosis 
Maantien 9401 (Tunturintie) aluevaraussuunnitelma, Kolari
Get PDFYlläksen matkailukeskus on Suomen suurimpia matkailukeskuksia. Se on kasvanut viime vuosina ripeää vauhtia ja tällä hetkellä alueella on jo yli 23 000 vuodepaikkaa. Ylläksen alueelle on suunnitteilla useita suuria investointihankkeita sekä Äkäslompolon että Ylläsjärven puolelle, jotka lisäävät myös lähivuosina Ylläksen majoituskapasiteettia huomattavasti.
Maantien 9401 (Tunturintie) aluevaraussuunnitelman laatiminen Äkäslompolon kylän kohdalla on jatkoa vuonna 2012 laaditulle Ylläksen liikennesuunnitelmalle, jossa se oli liikennesuunnitelman kärkihankkeita. Aluevaraussuunnitelma on laadittu Lapin ELY- keskuksen ja Kolarin kunnan toimeksiannosta Sito Oy:n Rovaniemen toimistossa, jossa työstä on vastannut ins. Pirkka Hartikainen.ei tietoa saavutettavuudest
Linked collectors and determiners for: UWIZM Birds.
No full textNatural history specimen data linked to collectors and determiners held within, "UWIZM Birds". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/3578a610-9401-4d52-9d06-69042e9b3543">https://bionomia.net/dataset/3578a610-9401-4d52-9d06-69042e9b3543</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/3578a610-9401-4d52-9d06-69042e9b3543">https://gbif.org/dataset/3578a610-9401-4d52-9d06-69042e9b3543</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: UWIZM Birds.
No full textNatural history specimen data linked to collectors and determiners held within, "UWIZM Birds". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/3578a610-9401-4d52-9d06-69042e9b3543">https://bionomia.net/dataset/3578a610-9401-4d52-9d06-69042e9b3543</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/3578a610-9401-4d52-9d06-69042e9b3543">https://gbif.org/dataset/3578a610-9401-4d52-9d06-69042e9b3543</a>. Formatted as a Frictionless Data package
California Poll: 9401 -- January 9-15, 1994
No full textThe Field Poll, established in 1945 as The California Poll by Mervin Field, has operated continuously as an independent, non-partisan, media-sponsored public opinion news service. Each year the Field Polls cover a wide range of political and social topics examining California public opinion. Continuing measures are made of voter support for leading political figures vying for major state and federal offices, job ratings of important political figures and reactions to significant political events. Voter awareness, understanding and predispositions of major campaign issues and salient statewide ballot propositions are also tracked over time. For poll 9401 N=1008
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Daressy, G., Textes et dessins magiques (Catalogue général du Musée du Caire Nos 9401-9449. Le Caire. 1903
No full textPiehl Karl Fredrik. Daressy, G., Textes et dessins magiques (Catalogue général du Musée du Caire Nos 9401-9449. Le Caire. 1903. In: Sphinx : revue critique embrassant le domaine entier de l'égyptologie, vol. 7, 1903. pp. 171-172
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