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TP-9201, A Glycoprotein IIb/IIIa Platelet Receptor Antagonist, Prevents Rethrombosis After Successful Arterial Thrombolysis in the Dog
No full text
Background and Purpose
We examined the ability of TP-9201, a platelet glycoprotein IIb/IIIa receptor antagonist, to prevent carotid artery rethrombosis in the anesthetized dog.
Methods
Occlusive thrombosis was induced by electrolytic injury of the left carotid artery. Thirty minutes later, 0.05 U/kg of anisoylated plasminogen streptokinase activator complex (APSAC) was infused locally to achieve clot lysis. Carotid artery recanalization was followed immediately by the infusion of either saline (10 mL/h, 240 minutes; n=9), low-dose TP-9201 (120 μg/kg plus 3 μg · kg
–1
· min
–1
, 240 minutes; n=7), or high-dose TP-9201 (185 μg/kg plus 5 μg · kg
–1
· min
–1
, 240 minutes; n=7). Ex vivo platelet aggregation responses to ADP or arachidonic acid were determined.
Results
TP-9201 produced complete inhibition of platelet aggregation in citrated platelet-rich plasma but a partial and dose-dependent inhibition in heparinized platelet-rich plasma. A twofold and eightfold increase in the template bleeding time was associated with the infusion of low-dose and high-dose TP-9201, respectively. There were frequent cyclic flow reductions in both the saline and low-dose TP-9201–treated groups after thrombolysis. However, the high-dose TP-9201–treated group exhibited a sustained flow with minimal evidence of cyclic flow reductions. At the conclusion of the protocol, patent vessels were found more frequently in the high-dose TP-9201 (5/7;
P
=.0048) than in the low-dose TP-9201 treatment group (2/7;
P
=.17) when compared with the saline group (0/9). Infusion of high-dose TP-9201 was associated with a significant reduction in the thrombus mass as compared with the control vessels.
Conclusions
Administration of TP-9201 in conjunction with successful thrombolysis inhibited ex vivo platelet aggregation and prevented rethrombosis of the canine carotid artery. This study demonstrates that TP-9201, an inhibitor of the platelet GPIIb/IIIa receptor, can inhibit platelet–vessel wall interaction and thus prevent rethrombosis.
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Corrective action baseline report for underground storage tank 2331-U Building 9201-1
No full textThe purpose of this report is to provide baseline geochemical and hydrogeologic data relative to corrective action for underground storage tank (UST) 2331-U at the Building 9201-1 Site. Progress in support of the Building 9201-1 Site has included monitoring well installation and baseline groundwater sampling and analysis. This document represents the baseline report for corrective action at the Building 9201-1 site and is organized into three sections. Section 1 presents introductory information relative to the site, including the regulatory initiative, site description, and progress to date. Section 2 includes the summary of additional monitoring well installation activities and the results of baseline groundwater sampling. Section 3 presents the baseline hydrogeology and planned zone of influence for groundwater remediation
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Revised corrective action plan for underground storage tank 2331-U at the Building 9201-1 Site
No full textThis document represents the Corrective Action Plan for underground storage tank (UST) 2331-U, previously located at Building 9201-1, Oak Ridge Y-12 Plant, Oak Ridge, Tennessee. Tank 2331-U, a 560-gallon UST, was removed on December 14, 1988. This document presents a comprehensive summary of all environmental assessment investigations conducted at the Building 9201-1 Site and the corrective action measures proposed for remediation of subsurface petroleum product contamination identified at the site. This document is written in accordance with the regulatory requirements of the Tennessee Department of Environment and Conservation (TDEC) Rule 1200-1-15-.06(7)
California Poll: 9201 -- January 13-18, 1992
No full textThe Field Poll, established in 1945 as The California Poll by Mervin Field, has operated continuously as an independent, non-partisan, media-sponsored public opinion news service. Each year the Field Polls cover a wide range of political and social topics examining California public opinion. Continuing measures are made of voter support for leading political figures vying for major state and federal offices, job ratings of important political figures and reactions to significant political events. Voter awareness, understanding and predispositions of major campaign issues and salient statewide ballot propositions are also tracked over time. For poll 9201 N=1028
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Seismicity and stress distribution around Copiapo, northern Chile subduction zone using combined on- an off-shore seismic observations
No full textPhysics of the Earth and Planetary Interiors, v. 132, n. 1, p. 197-217, 2002. http://dx.doi.org/10.1016/S0031-9201(02)00052-3International audienc
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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