1,722,607 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Identification and characterization of glycoside hydrolases for biotechnological applications
No full textThe importance of carbohydrates in several biological processes is directly mirrored in a wide number of biotechnological applications, based mainly on glycoside hydrolases (GHs), including conversion of agricultural byproducts in fermentable sugars for the bioethanol production, the use of these biocatalysts in the formulation of laundry detergents and in food industry (e.g. hydrolysis of lactose and preparation of HFCS). Moreover, GHs are used also in several biomedical approaches, as the production of universal blood , the enzyme replacement therapy for the treatment of lysosomal storage diseases and as alterative to the chemical synthesis of therapeutic biomolecules as heparin and galactooligosaccharides.
The development of a new class of enzyme, the glycosynthases (GS), obtained by mutating glycoside hydrolases, represent reliable alternative for the chemo-enzymatic synthesis of oligosaccharides. Here, the key of this approach is to cancel the hydrolytic activity of the enzyme by site-directed mutagenesis, but maintaining intact the structure of the active site. Therefore, by using substrate donor and certain reaction conditions, the engineered enzymes are able to synthesize products in quantitative yield.
This thesis is directed to the identification and characterization of glycosyl hydrolase for biotechnological applications and was divided in two different parts. The first part (Chapters I and II) is aimed to the application of glycosidases in the oligosaccharides synthesis. In particular, I adressed my work to the study and characterization of the catalytic mechanism of a beta-galactosidase from the moderate thermophile Alicyclobacillus acidocaldarius (Aaβgal) for the development of a new β-galactosynthase (Chapter I). Moreover I have characterized a new alpha-galactosynthase from the hyperthermophile Thermotoga maritima (TmGalA D327G) (Chapter II) to validate the approach based on the use of beta-glycosyl azide donors recently proposed.
The second part of this thesis (Chapters III and IV) is dedicated to the characterization in detail of two new glycoside hydrolases: an alpha-glycosidase SSO1353 and an alpha-mannosidase (Ss-alpha-Man) both from the hyperthermophilic crenarchaeon Sulfolobus solfataricus. The characterization of SSO1353 was directed to the study of the catalytic mechanism and in particular to the identification of nucleophile and acid/base residues. Differently, the study of Ss-alpha-Man activity was directed to the analysis of its substrate specificity toward glycoconjugates and glycoproteins
Anti-lysozyme c-1 antibodies 9122 and 9124 specifically recognized lysozyme c-1.
No full text<p>(A) Western blot showing cross-reaction of lysozyme c-1 antibodies with salivary glands from <i>An. gambiae</i> G3 (lane 1 with 9122; lane 2 with 9124), with salivary glands from <i>An. stephensi</i> (lane 3 with 9122) and no cross-reaction of salivary gland extracts with pre-immune serum (lane 4). (B) Western blot showing cross-reaction of 9122 antibodies (lane 1 and 2) or 9124 (lane 3 and 4) or pre-immune serum (lane 5 and 6) with recombinant lysozyme c-1 purified from <i>E. coli</i> (lane 1, 3 and 5) and from conditioned medium of 4a3B cells (lane 2, 4 and 6). (C) Alignment of the <i>An. gambiae</i> lysozyme c-1 peptide (underlined) used to generate antibodies with other <i>An. gambiae</i> homologues and an orthologue from <i>An. stephensi</i>. (D) Coomassie stained gel showing <i>E. coli</i> expressed recombinant lysozyme c-1 (lane 1); partially purified recombinant lysozyme c-2 (lane 2) and partially purified recombinant lysozyme c-4 (lane 4). (E) Western blot showing cross-reaction of lysozyme c-1 antibodies (9122) with purified recombinant lysozyme c-1 (lane 1) and absence of cross-reactivity with partially purified lysozymes c-2 and c-4 (lanes 2 and 4) and serum proteins from mouse (lane MB).</p
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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