1,720,969 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Searching for endogenous substrates of organic cation transporters by selective metabolomics
Full text link膜輸送体OCT1/SLC22A1は、OCT1基質薬の体内動態を規定する因子の一つである。本研究は、OCTs阻害剤の投与で変化する内因性基質を探索し、OCTs輸送機能を反映したバイオマーカーとしての有用性を確立することを目的とした。OCTｓ阻害剤を投与したマウスの血漿において、acylcarnitines濃度が上昇した。In vitroにおいて、OCT1がacylcarnitineの排出輸送に関与することが示唆された。血漿中acylcarnitinesは、OCTs阻害のバイオマーカー候補であることが示された。Organic cation transporters (OCTs) are involved in hepatic and renal distribution of various substrates, and may be primarily involved in pharmacokinetics of some substrate drugs. The aim of the present study is to search endogenous OCTs substrates. According to the untargeted metabolome analysis, plasma concentration of some acylcarnitines in OCT’s inhibitors treated mice were higher than that in vehicle-treated mice. Efflux of acetylcarnitine was also observed in from oocytes expressing OCT1. Thus, acylcarnitines were presumably endogenous OCT1 substrates although the role of OCTs in their tissue distribution should be further evaluated.研究課題/領域番号:18K06745, 研究期間(年度):2018-04-01 – 2021-03-31出典：「選択的メタボロミクスによる有機カチオン膜輸送体の生体内基質同定と生理的機能の解明」研究成果報告書 課題番号18K06745
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K06745/18K06745seika/）を加工して作成金沢大学医薬保健研究域薬学系research repor
Inhibitory mechanisms of hepatic uptake transporters/OATP during renal failure
Full text link一部の肝消失型薬物は、血中消失が慢性腎障害患者で遅延し、この原因として患者血漿中で蓄積する一部の尿毒素による肝膜輸送体のdirect inhibitionが報告されているが、他の尿毒素による阻害やdirect inhibition以外の作用は未解明である。本研究では、p-cresyl sulfateによる肝膜輸送体OATP1B1のdirect inhibitionとindoxyl sulfateによるOATP1B1のlong-lasting inhibitionを明らかにした。本研究で明らかになった阻害作用は、慢性腎障害時におけるOATP1B1基質薬の血中消失の遅延を一部説明しうるものである。Several uremic toxins have been proposed to inhibit hepatic uptake transporters. The purpose is to clarify possible long-lasting inhibition of OATP1B1 by uremic toxins. OATP1B1-mediated uptake of [3H]estrone sulfate (E3S) was examined after co-incubation or preincubation with uremic toxins in HEK293/OATP1B1 cells and primary cultured human hepatocytes. Among 21 uremic toxins, indoxyl sulfate (IS), CMPF and p-cresyl sulfate directly inhibited OATP1B1 mediated-uptake of E3S, but only IS exhibited inhibitory effect even after preincubation. Such inhibition of E3S uptake by preincubation with IS was more remarkable than that by its co-incubation, and observed in preincubation time- and concentration-dependent manners. Preincubation with IS also decreased uptake of E3S in human hepatocytes in primary culture. Overall, the long-lasting inhibition in the presence of IS could at least partially explain the delayed elimination of OATP1B1 substrate drugs during severe renal failure.研究課題/領域番号:26860099, 研究期間(年度):2014-04-01 - 2016-03-31出典：研究課題「慢性腎障害患者での肝輸送体OATP機能低下の機序と血漿中薬物濃度変化の定量的予測」課題番号26860099
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860099/26860099seika/）を加工して作成金沢大学医薬保健研究域薬学系research repor
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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