1,721,006 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Mechanisms for malignant tumor progression based on acquisition of 3-D invesiveness and regulation of epithelial morphogenesis
Full text linkがん細胞の高い浸潤性はがん転移につながる。本研究は、がん細胞における浸潤能獲得機構をエピジェネティック制御異常ならびにHGF-Met系シグナル特性から明らかにするとともに、HGF-Met相互作用を基盤として人工Met制御分子の創製を目的とした。その結果、(1) PRC複合体構成分子のタンパク質分解異常による機能破綻が、MMP-2を含む浸潤関連遺伝子の発現OFF→ONに関与すること、(2) Met-low→Met-highへの階層的発現変化が悪性黒色種の腫瘍成長、浸潤・転移性に関与することを明らかにするとともに、(3) 環状ペプチド性人工Met-アゴニスト/人工HGFの創製に成功した。Tumor invasion, a typical characteristic of malignant tumors, is regulated not only by intrinsic gene expression profile but also extracellular factors. Met activation by HGF participates in tissue regeneration and tumor invasion. We here found that 1) aberrant proteasome-mediated proteolysis in PRC complex participates in activation of genes (e.g., MMP-2) involved in acquisition of 3-D invasiveness in human malignant mesothelioma cells, and 2) Met expression is regulated by hierarchal equilibrium between Met-low and Met-high populations in malignant melanoma cells, by which invasive and metastatic characteristics is conferred. Based on background for HGF-Met protein-protein interactions, Met-binding cyclic peptides were obtained by RaPID system, and the dimerized peptides induced Met activation and Met-mediated biological responses, in indistinguishable ability to HGF. Thus, we succeeded in generation of artificial Met-agonist / artificial HGF composed of macrocyclic peptide.研究課題/領域番号:24300329, 研究期間(年度):2012-04-01 – 2015-03-31出典：研究課題「3-D浸潤性獲得と上皮形態形成制御を基盤とする腫瘍悪性化機構の研究」課題番号24300329
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24300329/24300329seika/)を加工して作成金沢大学がん進展制御研究所research repor
Metレセプター過剰発現に基づく悪性中皮腫の治療とNK4による制癌の至適化
Full text link私達はHGFアンタゴニストとしてNK4を見いだすとともに、NK4は血管新生阻害作用も有する2機能性分子として、複数の癌に対して浸潤・転移阻害、成長阻害、延命といった制癌作用を発揮することを明らかにした。本研究は悪性中皮腫に対するNK4の制癌作用を明らかにすることを目的とし、平成19年度において以下の成果を得た。
1.ヒト悪性中皮種細胞(7種類)すべてにMet受容体の発現が認められ、NK4はHGFに依存したMet受容体のチロシンリン酸化、中皮種細胞の遊走、コラーゲンゲル内浸潤を阻害した。
2.NK4はコラーゲンゲル内で培養した悪性中皮種細胞の増殖、ならびに軟寒天培地でのコロニー形成を抑制した。
3.ヒト悪性中皮種の皮下移植モデルを用いて、NK4発現用アデノウイルスベクターを腫瘍内に投与した。NK4遺伝子治療により腫瘍血管密度が低下し、腫瘍の成長は対照の26%に阻害された。NK4による成長抑制には、腫瘍血管新生阻害に加え、悪性中皮腫細胞の増殖に対する直接的な抑制作用が関与していると考えられる。
4.NK4は血管内皮細胞に対してフィブロネクチンの細胞表面構築を阻害した。そこでNK4に親和性のある血管内皮細胞由来の細胞膜分子の精製・同定、共局在の解析、発現抑制などによりNK4結合分子を絞り込んだ。NK4はMet/HGF受容体とは異なる分子に結合することによってフィブロネクチンの細胞外構築を阻害する結果、増殖・生存を支えるインテグリンを介したシグナルを阻害することによって血管新生を阻害すると考えられる。
NK4による悪性中皮腫細胞の増殖・コロニー形成阻害はNK4の新たな生物活性であり、どのようなメカニズムで抑制作用を示すか解析を進めることが重要である。一方、NK4は胸膜・腹膜における悪性中皮腫の成長ならびに浸潤・伸展を抑制する制癌法になることが期待される。研究課題/領域番号:18015031, 研究期間(年度):2006 – 2007出典：「Metレセプター過剰発現に基づく悪性中皮腫の治療とNK4による制癌の至適化」研究成果報告書 課題番号18015031
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18015031/)を加工して作成金沢大学がん進展制御研究所research repor
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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