1,737,864 research outputs found
MOESM1 of MiR-876-5p modulates head and neck squamous cell carcinoma metastasis and invasion by targeting vimentin
No full textAdditional file 1: Figure S1. MiR-876-5p had no significant effect on proliferation in HNSCC cells. (A) CCK-8 growth curves of CAL27 and HN6 cell lines after transfection. The effects on proliferation of HNSCC cells was not significantly different between the miR-876-5p mimics and inhibitors. (B) The cell-cycle analysis by flow cytometry revealed no significantly different in S phase between the miR-876-5p mimics and inhibitors. *P<0.05, **P<0.01, ***P<0.001
CircNFIX knockdown inhibited AML tumorigenicity by the miR-876-3p/TRIM31 axis
No full textAcute myeloid leukemia (AML) is one of the most common malignant myeloid diseases in adults with a dismal prognosis. We aimed to explore the effects of circNFIX on the proliferation and apoptosis of AML cells. The expressions of circNFIX, miR-876-3p and tripartite motif (TRIM) 31 in the bone marrow specimens of AML patients and AML cell lines were detected by qRT-PCR or western blot. Cell proliferation was evaluated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and 5-ethynyl-29-deoxyuridine (EdU) assays. Cell cycle and apoptosis were analyzed by flow cytometry. Western blot was used to detect protein expression. The relationship between miR-876-3p and circNFIX or TRIM31 was identified by dual-luciferase reporter assay or RNA pull-down assay. The expression level of circNFIX was significantly increased in the bone marrow samples of AML patients and AML cells when compared with normal controls. CircNFIX silencing inhibited AML cell proliferation and promoted apoptosis. Inhibition of miR-876-3p reversed the effect of circNFIX knockdown on AML cell progression. In addition, circNFIX indirectly regulated TRIM31 through miR-876-3p. Further, TRIM31 overexpression counteracted the effect of circNFIX silencing on AML cell proliferation and apoptosis. CircNFIX knockdown could suppress the proliferation and induce the apoptosis of AML cells by targeting the miR-876-3p/TRIM31 axis.</p
Development of a Continuous Flow Process for the Efficient Preparation of Anti-Tuberculosis-Specific Drug TBAJ-876
No full textPreviously, the first asymmetric synthesis of anti-tuberculosis
agent TBAJ-876 had been successfully achieved using a synergistic
Li/Li catalysis approach, yielding excellent results on a 5 g scale.
However, scaling up the process presents significant challenges due
to its poor repeatability and safety concerns associated with the
commercial scale use of organolithium reagents. In this paper, we
describe the design, development, and scale-up of a continuous flow
process for the synthesis of TBAJ-876. Notably, our continuous process
not only allowed us to synthesize TBAJ-876 at a 100 g reaction scale,
an achievement unattainable through batch processing, but it also
significantly reduced the reaction time, ensuring robustness, efficiency,
and scalability. This method provides a viable pathway for the large-scale
industrial production of compounds, such as TBAJ-876
High Yielding, Multigram-Scale Synthesis of TBAJ-876 Fragment, 876A-B
No full textTBAJ-876 is an anti-tuberculosis drug shown to have high activity against multi-drug resistant tuberculosis (TB). We report a very efficient synthesis of the TBAJ-876 fragment 876A-B using an aldol condensation strategy starting from 6-bromo-3,4-dihydroquinolin-2(H)-one. The synthesis has been accomplished at multigram scale without the need of chromatography purification steps
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Rhetoric [876]
No full textRhetoric.
This manuscript is now IO Islamic 1282 in the India Office collections.
[metadata: Otto Loth, A Catalogue of the Arabic Manuscripts in the Library of the India Office, (volume 1), no. 876 here with further notations and hyperlinks].
876.
1282. Size 101/4 in. by 6 in.; foll. 344. Twenty-one lines in a page.
Glosses on المطوّل , by ׳ABD AL-ḤAKÎM SIYÂLKÛTÎ (d. soon after A.H. 1060). Cf. Ḥ. Kh. vii. 798. These glosses have been printed at Constantinople, A.H. 1227 and 1241.2
Beginning: قوله افتتح كتابه الخ اى كتابه المقدَّر فى الذهن الخ.
Plainly written in Nasta’liḳ, by Ḥâfiz Muḥammad 'Alî. Revised. Some notes. Foll. 8-9 and foll. 10-11 should be transposed.
[Hastings.]
2 Cf. Cat. Bible. Sprenger. 1087, and Zenker, Biblioth. Orientalis, i. no. 330
- …
