1,742,477 research outputs found
Aerosolized BC-819 inhibits primary but not secondary lung cancer growth.
Get PDFDespite numerous efforts, drug based treatments for patients suffering from lung cancer remains poor. As a promising alternative, we investigated the therapeutic potential of BC-819 for the treatment of lung cancer in mouse tumor models. BC-819 is a novel plasmid DNA which encodes for the A-fragment of Diphtheria toxin and has previously been shown to successfully inhibit tumor growth in human clinical study of bladder carcinoma. In a first set of experiments, we examined in vitro efficacy of BC-819 in human lung cancer cell-lines NCI-H460, NCI-H358 and A549, which revealed >90% reduction of cell growth. In vivo efficacy was examined in an orthotopic mouse xenograft lung cancer model and in a lung metastasis model using luminescent A549-C8-luc adenocarcinoma cells. These cells resulted in peri- and intra-bronchiolar tumors upon intrabronchial application and parenchymal tumors upon intravenous injection, respectively. Mice suffering from these lung tumors were treated with BC-819, complexed to branched polyethylenimine (PEI) and aerosolized to the mice once per week for a period of 10 weeks. Using this regimen, growth of intrabronchially induced lung tumors was significantly inhibited (p = 0.01), whereas no effect could be observed in mice suffering from lung metastasis. In summary, we suggest that aerosolized PEI/BC-819 is capable of reducing growth only in tumors arising from the luminal part of the airways and are therefore directly accessible for inhaled BC-819
Resolución UNRN N° 819/2009. Aceptar la donación de inmueble.
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 819/2009. Aceptar la donación de inmueble.fals
Resolución UNRN Nº 819/2010. Modificase el Anexo II de la Resolución UNRN Nº 406/2009.
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN Nº 819/2010. Modificase el Anexo II - Fondos Rotatorios - Instructivo para las Rendiciones - Punto 6 de la Resolución UNRN Nº 406/2009.fals
Akkadian fragments, tablet concordance KUB XXXVII 129 - CTH 819
No full textTranscription of the tablet concordance KUB XXXVII 129 (inventory no. 678/c) related to the Akkadian fragments. Emmanuel Laroche translated this text as "Fragments,” and classified in the category of Sumero-Akkadian literature in diverse texts (Catalogue des textes Hittites, No. 819).Paper (1 sheet
Akkadian fragments, tablet concordance KBo IX 51 - CTH 819
No full textTranscription of the tablet concordance KBo IX 51 (inventory no. 246/n) related to the Akkadian fragments. Emmanuel Laroche translated this text as "Fragments,” and classified in the category of Sumero-Akkadian literature in diverse texts (Catalogue des textes Hittites, No. 819).Paper (1 sheet
Akkadian fragments, tablet concordance KBo IX 51 - CTH 819
No full textTranscription of the tablet concordance KBo IX 51 (inventory no. 246/n) related to the Akkadian fragments. Emmanuel Laroche translated this text as "Fragments,” and classified in the category of Sumero-Akkadian literature in diverse texts (Catalogue des textes Hittites, No. 819).Paper (1 sheet
Akkadian fragments, tablet concordance KBo VII 3 - CTH 819
No full textTranscription of the tablet concordance KBo VII 3, also published as KBo XXXVI 29 (inventory no. 285/a +34/k) related to the Akkadian fragments. Emmanuel Laroche translated this text as "Fragments,” and classified in the category of Sumero-Akkadian literature in diverse texts (Catalogue des textes Hittites, No. 819).Paper (1 sheet
Akkadian fragments, tablet concordance KBo VII 3 - CTH 819
No full textTranscription of the tablet concordance KBo VII 3, also published as KBo XXXVI 29 (inventory no. 285/a +34/k) related to the Akkadian fragments. Emmanuel Laroche translated this text as "Fragments,” and classified in the category of Sumero-Akkadian literature in diverse texts (Catalogue des textes Hittites, No. 819).Paper (1 sheet
Union Pacific (UP) 819
No full textA photograph print showing Union Pacific (UP) 819, 4-8-4, on train No. 22, Lawrence, KS
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