1,720,957 research outputs found
マウス胎盤形成時の脱落膜に出現する新規のGFAP/S100β陽性細胞の機能解析
Get PDF胎盤形成時に出現するGFAP/S100β陽性細胞について解析を行った結果、当該細胞は免疫担当細胞とは異なる特性を有し、胎生10.5日目から脱落膜に出現し始めることを明らかにした。この細胞をGLAST-CreERT2システムで追跡するモデルを確立し、経時的に解析した結果、マウス脱落膜のみならず、ラビリンス層にも分布することが新たに分かった。この細胞は血管周囲に分布しており、何らかの血管透過性や収縮などの血管制御に関わる機能を有する可能性が示唆された。これまで知られているラビリンス構成細胞の各マーカーで染色したところ、いずれのマーカーも陽性にならないことから、新たな細胞であることが示唆された。As a result of analysis of GFAP / S100β-positive cells appearing during placentation, it was revealed that the cells have different characteristics from immunocompetent cells and start to appear in the decidua at 10.5 embryonic days. As a result of establishing a model for tracking these cells with the GLAST-CreERT2 system and analyzing them over time, it was newly found that they are distributed not only in the mouse decidua but also in the labyrinth layer. These cells are distributed around blood vessels, suggesting that they may have some function related to blood vessel regulation such as vascular permeability and contraction. Staining with each marker of the labyrinth-constituting cells known so far, none of the markers became positive, suggesting that the cells are novel cells.研究課題/領域番号:18K16761, 研究期間(年度):2018-04-01 - 2020-03-31出典：「マウス胎盤形成時の脱落膜に出現する新規のGFAP/S100β陽性細胞の機能解析」研究成果報告書 課題番号18K16761
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K16761/18K16761seika/)を加工して作成金沢大学附属病院周産母子センターresearch repor
A novel third mesh-like myometrial layer connects the longitudinal and circular muscle fibers -A potential stratum to coordinate uterine contractions-
Get PDFAlthough it is well-known that the mammalian myometrium is composed of longitudinal (outer) and circular (inner) layers, the precise mechanisms that coordinate both muscular contractions to produce peristaltic movements remain unclear.By treatment with CUBIC tissue-clearing method, we identified a novel muscle layer, a middle layer of the myometrium, which anatomically connects the conventional outer longitudinal and inner circular muscles. This new layer was visualized as a mesh-like structure and this structure was observed throughout the whole uterus from proximal to distal sites. In this area, CD31-positive vessels were abundantly localized around the mesh-like muscle fibers. In addition, CD34-positive uterine telocytes and tubulin β-3-positive nerve fibers were closely located in this middle layer. These findings indicate the presence of a novel mesh-like stratum that connects longitudinal and circular muscle layers, and suggest its coordinating role in myometrial contractions.組織透明化技術を用いたマウス子宮筋の解析から、これまで認識されてこなかった新たな子宮筋構造を同定した。光シート顕微鏡で取得した連続画像を詳細に解析すると、内輪筋に起始した筋線維束が外縦筋に連絡し、内輪と外縦を橋渡しする構造を呈していた。この領域には血管構造が豊富に観察され、さらにTUBB3陽性の神経軸索も入力されていることが明らかになった。また子宮テロサイトもメッシュ状の筋線維束に沿って走行するのが観察され、神経軸索終末がテロサイトに接している様子も観察された。以上から、長い管腔構造を呈するげっ歯類の子宮でありながら、局所の巧みな収縮を自律的に起こす起点になっている可能性が示唆された。研究課題/領域番号:20K18186, 研究期間(年度):2020-04-01 – 2022-03-31出典：研究課題「マウス子宮筋中層における新規メッシュ構造の生理学的意義」課題番号20K18186
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20K18186/20K18186seika/）を加工して作成金沢大学附属病院research repor
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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