1,721,009 research outputs found
Coffee diterpens inhibit prostate cancer progression
No full textCoffee is reported to have an anti-cancer effect on advanced prostate cancer patients; however, there are no study showing its mechanism on cancer cells. Among a lot of ingredients in coffee, coffee diterpene, kahweol and cafestol showed a strong anti-proloferation effect on human prostate cancer cells. These diterpenes also showed anti-proliferation and anti-migration effects on DU145-TxR (paclitaxel-resistant DU145) and DU145-TxR-CxR (cabazitaxel-resistant DU145-TxR) cells. STAT3 and AKT existed in a downstream of CCL2-CCR2 which is a diterpene-targeted axis.コーヒーは進行前立腺癌の進展を抑制する可能性が報告されているが、進展制御機構は明らかにされていない。数あるコーヒー成分の中でジテルペンであるカウェオールとカフェストールがヒト前立腺癌細胞に対し強力な増殖抑制効果を発揮した。これらジテルペンは我々が独自に樹立したDU145のパクリタキセル耐性株DU145-TxR（本株はドセタキセルに耐性を持つことを確認済み）と、DU145-TxRのカバジタキセル耐性株DU145-TxR-CxRに対しても有効であった。タキサン耐性には、ジテルペンのターゲットであるCCL2-CCR2の下流の2つのシグナル、STAT3およびAKTが関与していることが示唆された。研究課題/領域番号:19K09685, 研究期間(年度):2019-04-01 - 2022-03-31出典：研究課題「ジデルペンによる前立腺癌進展制御機構の解明と新規化合物の開発」課題番号19K09685
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K09685/19K09685seika/）を加工して作成金沢大学附属病院泌尿器科research repor
The mechanism of prostate cancer progression via the macrophage infiltration into prostate cancer microenvironment
No full textアンドロゲン受容体シグナルの有無にかかわらず、高転移能を有する前立腺癌細胞はCCL2をより多く産生し、CCL2は前立腺癌細胞の転移能を亢進させるという悪循環が形成されている可能性が示唆された。CCL2はマクロファージの前立腺癌組織への浸潤を誘導し、マクロファージから分泌されるケモカインによってさらに前立腺癌細胞の転移能が亢進する可能性が示された。Human prostate cancer cells with high metastatic ability can secrete more CCL2 than those with low metastatic ability and CCL2 can induce prostate cancer cell migration, regardless of the presence of the suppression of androgen/androgen receptor signal. In addition, CCL2 induce the infiltration of macrophages into prostate cancer tissue, and then chemokines secreted by infiltrated macrophages can induce prostate cancer migration.研究課題/領域番号:25861413, 研究期間(年度):2013-04-01 – 2015-03-31出典：研究課題「マクロファージとの相互作用を介した前立腺癌細胞の浸潤・転移促進機序の解明」課題番号25861413
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25861413/25861413seika/)を加工して作成金沢大学医薬保健研究域医学系research repor
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Androgen/ARシグナルの抑制によるCCL20を介した免疫寛容誘導の解明
No full text進行前立腺癌に対するアンドロゲン除去療法は有効であるが、いずれ無効な状態となる。アンドロゲン受容体シグナルが抑制されることによって、前立腺癌細胞の増殖は抑制されるが、前立腺癌細胞からCCL20が分泌され、癌細胞自身（あるいは近傍の前立腺癌細胞）に作用し、結果的に前立腺癌細胞の転移能を高める可能性が明らかとなった。また転移能が高い前立腺癌細胞からはCCL20が多く分泌されており、CCL20が転移能を高めている可能性が裏付けられた。The curative effects of androgen-deprivation therapy may become severely compromised when the prostate cancer cells develop into a castration-resistant stage. Blockade of androgen-androgen receptor signaling inhibited prostate cancer cell proliferation; however, it could increase metastatic ability of prostate cancer cells via CCL20 by autocrine manner. Prostate cancer cells with high metastatic ability also showed high expression of CCL20, suggesting that CCL20 adds metastatic potential to prostate cancer cells.研究課題/領域番号:16K10998, 研究期間(年度):2016-04-01 - 2019-03-31出典：研究課題「Androgen/ARシグナルの抑制によるCCL20を介した免疫寛容誘導の解明」課題番号16K10998
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10998/16K10998seika/）を加工して作成research repor
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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