1,722,995 research outputs found
The relationship between nāḇî\' and miṯnabbê in the Hebrew Bible
No full textA heterogeneidade do profetismo israelita pode ser abordada de diversas maneiras. Na presente pesquisa, elegemos o binômio nāḇî\' e miṯnabbê como janela de observação para um estudo interdisciplinar dos fenômenos proféticos na Bíblia Hebraica, utilizando contribuições de diversas disciplinas. Nosso objetivo foi o de discutir uma questão que está sobre a mesa de debates dos pesquisadores, possuindo uma bibliografia que é vasta, porém inconclusiva A dificuldade dos scholars em afirmar em que medida o binômio nāḇî\'/miṯnabbê descreve ou não fenômenos distintos torna a questão complexa e instigante. Os capítulos do trabalho acompanham o recorte do estudo, que é composto por quatro narrativas: Nm 11, 1 Sm 10, Ez 13 e Mq 3. A forma participial miṯnabbê descreve o comportamento dos anciãos em face do nāḇî\' Moisés (Nm 11), a performance de Saul diante de um ḥeḇel neḇiʼim (grupo de profetas) em êxtase e ao som de música (1 Sm 10), bem como a atividade das profetisas-miṯnabb ͤ ʼōṯ, cuja racionalidade (designada pelo termo lêḇ, \"coração\") obstinada (šrr) é criticada pelo nāḇî\' Ezequiel (Ez 13). A condição profética dos anciãos e de Saul se relaciona com a vinda do ruaḥ (sopro, espírito) divino. O substantivo nāḇî\' está em questão também na crítica ao pagamento do profeta ávido por enganar (šeqer) e \"morder\" (nōšek) lucros e benefícios(Mq 3). Por meio do exame dessas passagens, levantamos discussões que resultaram em um comentário crítico sobre o profetismo israelita, que destaca a abertura de possibilidades de pesquisa suscitada pelo binômio nāḇî\'/miṯnabbêThe heterogeneity of the Israelite prophecy can be approached from several ways. In this study, we chose the binomial nāḇî\' and miṯnabbê as an observation window to an interdisciplinary study of the prophetic phenomena in the Hebrew Bible, using input from several disciplines. Our goal was to discuss an issue that is present in the current discussions of researchers, having a bibliography that is extensive but inconclusive. The difficulty researchers have to state to which extent the binomial nāḇî\'/miṯnabbê describes or not distinct phenomena makes the issue complex and instigating. The chapters of this work follow the scope of the study, which consists of four narratives: Nu 11, 1 Sa 10, Eze 13 and Mic 3. The participial form miṯnabbê describes the behavior of elders in the face of nāḇî\' Moses (Nu 11), the performance of Saul before a ḥeḇel neḇiʼim (group of prophets) in ecstasy and at the sound of music (1 Sa 10), as well as the activity of the prophetesses - miṯnabb ͤ ʼōṯ, whose obstinate (šrr) rationality (designated by the term lêḇ,\"heart\") is criticized by the nāḇî\' Ezekiel (Eze 13). The prophetic condition of the elders and Saul relates to the coming of the divine ruaḥ (blow, spirit). The noun nāḇî\' is emphasized also in the criticism about the payment of the prophet eager to cheat (šeqer) and to \"bite\" (nōšek) profitsand benefits(Mic 3). Through the examination of these passages, we raised discussions that resulted in a critical commentary on the Israelite prophecy, which highlights the opening of research possibilities raised by the binomial nāḇî\'/miṯnabb
AT-7687, a novel GIPR peptide antagonist, combined with a GLP-1 agonist, leads to enhanced weight loss and metabolic improvements in cynomolgus monkeys
No full textObjectives: Obesity represents a global health crisis with significant patient burdens and healthcare costs. Despite the advances with glucagon-like peptide-1 (GLP-1) receptor agonists in treating obesity, unmet needs remain. This study characterizes a novel glucose-dependent insulinotropic polypeptide receptor (GIPR) peptide antagonist, AT-7687, evaluating its potential to enhance obesity treatment. Methods: We assessed the in vitro potency and pharmacokinetics of AT-7687, alongside its therapeutic effects when administered subcutaneously (SC) alone and in combination with liraglutide to high-fat-diet-fed obese non-human primates (NHP). The study spanned a 42-day treatment period and a 15-day washout period. Results: AT-7687 demonstrated a subnanomolar cAMP antagonistic potency (pKB of 9.5) in HEK-293 cells and a 27.4 h half-life in NHPs. It effectively maintained weight stability in obese monkeys, whereas placebo recipients had an 8.6% weight increase by day 42 (P = 0.01). Monotherapy with liraglutide resulted in a 12.4% weight reduction compared to placebo (P = 0.03) and combining AT-7687 with liraglutide led to a 16.3% weight reduction (P = 0.0002). The combination therapy significantly improved metabolic markers, reducing insulin levels by 52% (P = 0.008), glucose by 30% (P = 0.02), triglycerides by 39% (P = 0.05), total cholesterol by 29% (P = 0.03), and LDL cholesterol by 48% (P = 0.003) compared to placebo. AT-7687 treatment was well tolerated and not associated with any side effects. Conclusions: This study underscores the potential of AT-7687 as a promising addition to current obesity treatments.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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