1,585 research outputs found
Fighting against Viral Hepatitis: Lessons from Taiwan
No full textViral hepatitis and its sequelae are important health problems worldwide, including Taiwan. For the last 40 years, Taiwan's scientists and health care providers have worked hard to control these sequelae, and the results have been excellent. The author, Ding-Shinn Chen, had a key role in planning and establishing the control program in Taiwan, and participated in the endeavors from the very beginning. In this perspective, he describes how he became interested in research as a medical student, his encounters with hepatitis B and C, how he and his colleagues started early detection of hepatocellular carcinoma (HCC), how he helped Taiwan's government create and implement the Viral Hepatitis Control Program, and how the effectiveness of the program in the decrease of hepatitis B carriage and HCC was monitored. He also discusses how he pioneered the use of interferon- plus ribavirin to treat chronic hepatitis C. Hepatitis B viral load as a risk factor for HCC and cirrhosis in hepatitis B surface antigen carriers is reviewed briefly, as is the prevention of sequelae by antiviral therapies. Finally, Dr. Chen discusses unresolved issues that must be addressed and predicts the changes of the patterns of liver disease in Taiwan beyond the mid-21st century, which is in part affected by the fight against viral hepatitis that was initiated in the early 1980s . CONCLUSION: Dr. Chen's perspective illustrates Taiwan's fight against viral hepatitis over the last 40 years. This experience can be shared by other countries in which the disease is equally prevalent
An ergodic theorem for flows on closed surfaces
No full textThe flows on closed surfaces can either be topologically transitive or metrically transitive. The Morse conjecture for flows on closed oriented surfaces as stated in Theorem A is discussed. Theorem A assumes that if a C1-flow ft on M has only finitely many equilibrium states, then, the flow ft is metrically transitive if it is topologically transitive. Then, as an immediate consequence, an improvement of the classical ergodic theorem of Birkhoff type (Theorem B) is discussed. In Theorem B, ??t is assumed to be an area-preserving flow on M having only finitely many equilibrium states. If ??t is a topologically transitive flow, then, the Birkhoff ergodic theorem is valid.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000077554600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Mathematics, AppliedMathematicsSCI(E)EICPCI-S(ISTP)
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
Discontinuous molecular dynamics for rigid bodies: Applications
No full textEvent-driven molecular dynamics simulations are carried out on two rigid-body systems which differ in the symmetry of their molecular mass distributions. First, simulations of methane in which the molecules interact via discontinuous potentials are compared with simulations in which the molecules interact through standard continuous Lennard-Jones potentials. It is shown that under similar conditions of temperature and pressure, the rigid discontinuous molecular dynamics method reproduces the essential dynamical and structural features found in continuous-potential simulations at both gas and liquid densities. Moreover, the discontinuous molecular dynamics approach is demonstrated to be between 3 and 100 times more efficient than the standard molecular dynamics method depending on the specific conditions of the simulation. The rigid discontinuous molecular dynamics method is also applied to a discontinuous-potential model of a liquid composed of rigid benzene molecules, and equilibrium and dynamical properties are shown to be in qualitative agreement with more detailed continuous-potential models of benzene. The few qualitative differences in the angular dynamics of the two models are related to the relatively crude treatment of variations in the discontinuous repulsive interactions as one benzene molecule rotates by another. (c) 2007 American Institute of Physics.PT: J; CR: ALDER BJ, 1959, J CHEM PHYS, V31, P459 BELLEMANS A, 1980, MOL PHYS, V39, P781 CACELLI I, 2004, J AM CHEM SOC, V126, P14278 CHAPELA GA, 1984, MOL PHYS, V53, P139 CHAPELA GA, 1989, CHEM PHYS, V129, P201 DELAPENA LH, 2007, J CHEM PHYS, V126 DEMICHELE C, 2006, J PHYS CHEM B, V110, P8064 DING F, 2003, PROTEINS, V53, P220 DUANE S, 1987, PHYS LETT B, V195, P216 DULLWEBER A, 1997, J CHEM PHYS, V107, P5840 FALCONE DR, 1967, J PHYS CHEM-US, V71, P2754 MACKERELL AD, 1998, J PHYS CHEM B, V102, P3586 NGUYEN HD, 2006, J AM CHEM SOC, V128, P1890 PRESS WH, 1992, NUMERICLA RECIPES FO RAPAPORT DC, 1979, J CHEM PHYS, V71, P3299 RAPAPORT DC, 2004, ART MOL DYNAMICS SIM VANZON R, CONDMAT0612404 VANZON R, IN PRESS J COMPUT PH ZACHAROPOULOS N, 2005, J CHEM PHYS, V122 ZHOU YQ, 1999, J MOL BIOL, V293, P917; NR: 20; TC: 0; J9: J CHEM PHYS; PG: 12; GA: 138VLSource type: Electronic(1
Counteracting loneliness: on the restorative function of nostalgia
No full textFour studies tested whether nostalgia can counteract reductions in perceived social support caused by loneliness. Loneliness reduced perceptions of social support but increased nostalgia. Nostalgia, in turn, increased perceptions of social support. Thus, loneliness affected perceived social support in two distinct ways. Whereas the direct effect of loneliness was to reduce perceived social support, the indirect effect of loneliness was to increase perceived social support via nostalgia. This restorative function of nostalgia was particularly apparent among resilient persons. Nostalgia is a psychological resource that protects and fosters mental health
Isomerism in the "south-east" of Sn-132 and a predicted neutron-decaying isomer in Pd-129
No full textExcited states in neutron-rich nuclei located south-east of Sn-132 are investigated by shell-model calculations. A new shell-model Hamiltonian is constructed for the present study. The proton-proton and neutron-neutron interactions of the Hamiltonian are obtained through the existing CD-Bonn Gmatrix results, while the proton-neutron interaction across two major shells is derived from the monopole based universal interaction plus the M3Y spin-orbit force. The present Hamiltonian can reproduce well the experimental data available in this region, including one-neutron separation energies, level energies and the experimental B(E2) values of isomers in Sn-134,Sn-136,Sn-138, Cd-130, and Pd-128. New isomers are predicted in this region, e.g. in Sn-135, Cd-131, Pd-129, In-132,In-134 and Ag-130, in which almost no excited states are known experimentally yet. In the odd-odd In-132,In-134 and Ag-130, the predicted very long E2life-times of the low-lying 5(-) states are discussed, demanding more information on the related proton-neutron interaction. The low-lying states of In-132 are discussed in connection with the recently observed gamma rays. The predicted 19/2(-) isomer in Pd-129 could decay by both electromagnetic transitions and neutron emission with comparable partial life-times, making it a good candidate for neutron radioactivity, a decay mode which is yet to be discovered. (C) 2016 The Author(s). Published by Elsevier B. V. This is an open access article under the CC BY license.National Natural Science Foundation of China [11235001, 11305272, 11375086, 11405224, 11435014, 11575007, 11535004, 11320101004]; Special Program for Applied Research on Super Computation of the NSFC Guangdong Joint Fund; Specialized Research Fund for the Doctoral Program of Higher Education [20130171120014]; Guangdong Natural Science Foundation [2014A030313217]; Fundamental Research Funds for the Central Universities [14lgpy29]; Pearl River S&T Nova Program of Guangzhou [201506010060]; Hundred-Talent Program (Chinese Academy of Sciences); United Kingdom Science and Technology Facilities Council [ST/L005743/1]SCI(E)[email protected]; [email protected]
Modern digital and analog communication systems / B.P. Lathi, Zhi Ding.
No full textIncludes bibliographical references and index.xxi, 903 pages.
Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication
No full text© The Author(s) 2010. Published by Oxford University PressGenome duplication requires accessory helicases to displace proteins ahead of advancing replication forks. Escherichia coli contains three helicases, Rep, UvrD and DinG, that might promote replication of protein-bound DNA. One of these helicases, Rep, also interacts with the replicative helicase DnaB. We demonstrate that Rep is the only putative accessory helicase whose absence results in an increased chromosome duplication time. We show also that the interaction between Rep and DnaB is required for Rep to maintain rapid genome duplication. Furthermore, this Rep–DnaB interaction is critical in minimizing the need for both recombinational processing of blocked replication forks and replisome reassembly, indicating that colocalization of Rep and DnaB minimizes stalling and subsequent inactivation of replication forks. These data indicate that E. coli contains only one helicase that acts as an accessory motor at the fork in wild-type cells, that such an activity is critical for the maintenance of rapid genome duplication and that colocalization with the replisome is crucial for this function. Given that the only other characterized accessory motor, Saccharomyces cerevisiae Rrm3p, associates physically with the replisome, our demonstration of the functional importance of such an association indicates that colocalization may be a conserved feature of accessory replicative motors.Biotechnology and Biological Sciences Research Council (BB/G005915/1 and BB/E0020690 to P.M.); MRC (G0800970 to R.G.L.); Leverhulme Trust (to C.J.R.). Funding for open access charge: BBSRC
Possible realization of negative refraction in Bose-Einstein condensates
No full textIt is well known that negative refraction (NR) can be achieved in left-handed materials. Recently, it is suggested that NR can also be realized in certain active right-handed materials. However, no experimental realization of that has been achieved yet. In this paper, further theoretical constraints on the material parameters are obtained, a possible experimental realization based on the Bose-Einstein condensation (BEC) is proposed, and the detecting method to verify NR is suggested. The feasibility of the proposal is demonstrated. Our conclusion is that this new type of NR can probably be realized in the BEC.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000292512500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Physics, Condensed MatterSCI(E)0ARTICLE4null8
Smarter 'All' : design and design research at the people centric era for China
No full textAuthor name used in this publication: Benny Ding LeongText in English and Korean2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishedPublisher permissio
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