1,722,841 research outputs found
EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung
No full textRecently, researchers are actively pursuing efforts to develop potent and selective ALK5 (TβRI) kinase inhibitors for clinical development. In this study, the authors examined a novel small molecule inhibitor of ALK5, 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl) -1H-imidazol-2-yl)methylamino)benzonitrile (EW-7195) to determine if it has potential for cancer treatment. The inhibitory effects of EW-7195 on TGF-β-induced Smad signaling and epithelial-to-mesenchymal transition (EMT) were investigated in mammary epithelial cells using luciferase reporter assays, immunoblotting, confocal microscopy and wound healing assays. In addition, the suppressive effects of EW-7195 on mammary cancer metastasis to lung were examined using a Balb/c xenograft and MMTV/cNeu transgenic mice model system. The novel ALK5 inhibitor, EW-7195, inhibited the TGF-β 1- stimulated transcriptional activations of p3TP-Lux and pCAGA 12-Luc. In addition, EW-7195 decreased phosphorylated Smad2 levels and the nuclear translocation of Smad2 increased by TGF-β 1. In addition, EW-7195 inhibited TGF-β 1-induced EMT and wound healing of NMuMG cells. Furthermore, in xenografted Balb/c and MMTV/cNeu mice, EW-7195 inhibited metastasis to lung from breast tumours. The novel ALK5 inhibitor, EW-7195, efficiently inhibited TGF-β 1-induced Smad signaling, EMT and breast tumour metastasis to the lung in vivo, demonstrating that EW-7195 has therapeutic potential for the breast cancer metastasis to the lung. © 2011 Elsevier Ltd. All rights reserved
The two commentaries on Genesis attributed to Remigius of Auxerre; with a critical edition of Stegmuller 7195
No full textDuring the late 17th century, Chifflet attempted to publish a commentary on Genesis, Stegmuller 7195 (Scriptoribus Hebraeorum hic mos), attributed to Remigius of Auxerre. Soon after, Pez published another Genesis commentary, Stegmuller 7194 (Auctor huius operis), also attributed to Remigius. Due to this accident of printing history, Stegmuller 7194 erroneously became known as Remigius\u27 authentic commentary on Genesis. This thesis will reconsider the authorship of these Genesis commentaries by analysing their textual transmission, sources and styles. Eight of the 20 extant manuscripts of Stegmuller 7194 ascribe the text to Remigius. The stemma, however, shows that these manuscripts all derive from a Pentateuch commentary written at Freising in the late 10th century. All such manuscripts probably originated in Germany and Austria. The manuscripts of the other family were generally produced in France and none attribute Stegmuller 7194 to Remigius, while at least one attributes this text to Haimo. Meanwhile, 3 of the 10 extant manuscripts of Stegmuller 7195 attribute the text to Remigius. Significantly, the oldest manuscript mentioning Remigius, Vat. lat. 646 (late 9th- early 10th-century), has Auxerrois connections. The source analysis shows that Stegmuller 7194 used the Genesis commentaries of Alcuin and Hrabanus Maurus. Stegmuller 7195, which relied upon Hrabanus Maurus even more than Stegmuller 7194, also used Angelomus of Luxeuil and Adrevald of Fleury\u27s De benedictionibus patriarcharum. This suggests that Stegmuller 7194 was not written after 850, while Stegmuller 7195 was probably completed after 875. The two commentaries differ stylistically. Stegmuller 7194 follows its sources much more loosely than Stegmuller 7195. The exegesis of Stegmuller 7195 is strictly literal, while Stegmuller 7194 also addresses allegorical and tropological senses. The stylistic traits of both authors identified by previous scholars and parallels with other works by Haimo and Remigius are analyzed. Therefore, Remigius of Auxerre probably wrote Stegmuller 7195, a critical edition of which concludes the dissertation. Haimo of Auxerre probably wrote Stegmuller 7194, published in Migne, hitherto attributed to Remigius
Tariffs, Transport Costs and the WTO Doha Round: The Case of Developing Countries
Get PDFThe WTO Doha Round of multinational trade negotiations is labelled the “development round” to highlight the fact that progress could be achieved through the enhanced integration of the poor countries into the world economy. Since the trade agenda focuses to a large extent on the levels of direct and indirect trade barriers as well as other aspects of trade and competition policy, an important aspect of the relative trade performance of developing countries has been neglected somewhat. This paper argues that, in addition to trade barriers, other trade costs, such as communications and transport costs, have to be taken into account. These other costs can be significantly higher in developing countries, which impedes their successful integration into world markets.developing countries, transport costs, WTO Doha Round, International Relations/Trade,
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
FERREIRA, J. R. Eurípides: As suplicantes. 1. ed. Porto Alegre: Movimento, 2012. 78 p. ISBN 978-85-7195-150-1
No full textResenha de FERREIRA, J. R. Eurípides: As suplicantes. 1. ed. Porto Alegre: Movimento, 2012. 78 p. ISBN 978-85-7195-150-
FERREIRA, J. R. Eurípides: As suplicantes. 1. ed. Porto Alegre: Movimento, 2012. 78 p. ISBN 978-85-7195-150-1
No full textResenha de FERREIRA, J. R. Eurípides: As suplicantes. 1. ed. Porto Alegre: Movimento, 2012. 78 p. ISBN 978-85-7195-150-
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
The JRP statistical programs for high speed IBM digital computers [by] B. K. Radhakrishnan and Nils B. Mattsson, with the assistance of Norman A. Starr.
No full texthttp://deepblue.lib.umich.edu/bitstream/2027.42/7195/5/abv5851.0001.001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/7195/4/abv5851.0001.001.tx
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