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Publish or Perish Crossref of Jurnal Manajemen Stratejik dan Simulasi Bisnis, ISSN 2746-6868
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Jurnal Manajemen Stratejik dan Simulasi Bisnis, ISSN 2746-6868
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Publication name: Jurnal Manajemen Stratejik dan Simulasi Bisnis
ISSN: 2746-6868
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Additional file 1: of Dysregulation of miR-6868-5p/FOXM1 circuit contributes to colorectal cancer angiogenesis
No full textFigure S1. (A) qRT-PCR analysis of the expression of indicated miRNAs in HCT8 and HCT116 cells. (B & C) Transfection efficiency was measured by qRT-PCR. *p < 0.05, **p < 0.01. Figure S2. (A) Western blot analysis of FOXM1 expression in HCT116 cells transfected with empty control vector or FOXM1 expressing plasmid. (B) HUVECswere treatedwith the CM from indicated cells, and subjected to wound healing assay. Scale bar = 20 μm. (C) Xenografted tumors were excised at week 3 post the inoculation, and the tumor weight from different groups was compared. (D) Western blot analysis of FOXM1 expression in HCT116 cells transfected with shNC, sh1 and sh2 against FOXM1. (E) HUVECs were treated with the CM from HCT116 cells transfected with indicated vectors. Cell viability of HUVECs was measured by CCK8 assay. (F) HUVECs were co-cultured with HCT116 cells transfected with indicated vectors in transwell apparatus. Migrated HUVECs were quantified after co-culture for 24 h. Scale bar = 20 μm. (G) HUVECs were treated with the CM from indicated cells, and subjected to tube formation assay. Scale bar = 20 μm. *p < 0.05, **p < 0.01. Figure S3. The bivariate relation between the mRNA levels of FOXM1 and IL-8 in CRC samples from GEO dataset was assessed by Pearson’s correlation test. Figure S4. (A) qRT-PCR analysis of pre-miR-6868 expression in HCT116 cells with FOXM1 overexpression. (B) HCT8 and HCT116 cells were treated with 5-Azd (10 μM). The miR-6868-5p levels were examined by qRT-PCR after 48 h. miR-375 was used as positive control. (C) Western blot analysis of H3K27me3 expression in HCT116 cells upon GSK126 treatment. *p < 0.05, **p < 0.01. Figure S5. (A) The bivariate relation between the EXOC7 mRNA levels and miR-6868-5p levels in CRC samples was assessed by Pearson’s correlation test. (B) qRT-PCR analysis of pre-miR-6868 and miR-6868-5p expression in cells transfected with siNC or siDrosha. (C) qRT-PCR analysis of EXOC7 expression in HCT116 cells with FOXM1 overexpression. Table S1. Number of predicted binding sites in FOXM1 3’-UTR. Table S2. Sequences of primers used for qRT-PCR in this study. Table S3. Sequences of primers used for ChIP-qPCR in this study. Table S4. Correlation between miR-6868-5p expression and TNM stage in CRC samples. (DOCX 12322 kb
Dysregulation of miR-6868-5p/FOXM1 circuit contributes to colorectal cancer angiogenesis
No full textAbstract Background Transcription factor forkhead box M1 (FOXM1) is a crucial regulator in colorectal cancer (CRC) progression. However, the regulatory mechanisms causing dysregulation of FOXM1 in CRC remain unclear. Methods Dual-luciferase reporter assay was conducted to determine FOXM1 as miR-6868-5p target. The function of miR-6868-5p and FOXM1 in CRC angiogenesis was verified in vitro. Intratumoral injection model was constructed to explore the effect of miR-6868-5p on angiogenesis in vivo. Chromatin immunoprecipitation assays were used to assess direct binding of H3K27me3 to the miR-6868 promoter. Results Through integrated analysis, we identified miR-6868-5p as the potent regulator of FOXM1. Overexpression of miR-6868-5p in CRC cells inhibited the angiogenic properties of co-cultured endothelial cells, whereas silencing of miR-6868-5p had opposite effects. In vivo delivery of miR-6868-5p blocked tumor angiogenesis in nude mice, resulting in tumor growth inhibition. Rescue of FOXM1 reversed the effect of miR-6868-5p on tumor angiogenesis. Further mechanistic study revealed that FOXM1 promoted the production of IL-8, which was responsible for the miR-6868-5p/FOXM1 axis-regulated angiogenesis. Reciprocally, FOXM1 inhibited miR-6868-5p expression through EZH2-mediated H3K27me3 on miR-6868-5p promoter, thus forming a feedback circuit. Clinically, the level of miR-6868-5p was downregulated in CRC tissues and inversely correlated with microvessel density as well as levels of FOXM1 and IL-8 in tumor specimens. Conclusions Together, these data identify miR-6868-5p as a novel determinant of FOXM1 expression and establish a miR-6868-5p/FOXM1 regulatory circuit for CRC angiogenesis, providing potential target for CRC treatment
Theoretically generated vibration-rotation-inversion spectrum of Ar-NH3
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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Steigerung der Leistung von Umformanlagen durch Erforschung des Werkstoffverhaltens bei hohen Temperaturen und extremen Umformgeschwindigkeiten Gebrauchseigenschaften und Betriebsverhalten. Abschlussbericht. Dauer: 1.1.1975-30.6.1979
No full textSIGLETIB Hannover: Z 2297 (6868) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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