1,723,740 research outputs found
Circ_0001667 accelerates breast cancer proliferation and angiogenesis through regulating CXCL10 expression by sponging miR‐6838‐5p
No full textAbstract Background An increasing number of circular RNAs (circRNAs) have been shown to play an important role in the tumorigenesis of breast cancer. The aim of this study was to investigate the expression and function of circ_0001667 and its potential molecular mechanisms in breast cancer. Methods The expression levels of circ_0001667, miR‐6838‐5p and CXC chemokine ligand 10 (CXCL10) in breast cancer tissues and cells were detected by quantitative real‐time PCR. Cell counting kit‐8 assay, EdU assay, flow cytometry, colony formation and tube formation assays were used to detect cell proliferation and angiogenesis. The binding relationship between miR‐6838‐5p and circ_0001667 or CXCL10 was predicted using the starBase3.0 database and verified by dual‐luciferase reporter gene assay, RIP and RNA pulldown. Animal experiments were performed to assess the function of circ_0001667 knockdown on breast cancer tumor growth. Results Circ_0001667 was highly expressed in breast cancer tissues and cells, and its knockdown inhibited proliferation and angiogenesis of breast cancer cells. Circ_0001667 sponged miR‐6838‐5p, and inhibition of miR‐6838‐5p reversed the inhibitory effect of silencing circ_0001667 on proliferation and angiogenesis of breast cancer cells. MiR‐6838‐5p targeted CXCL10, and overexpression of CXCL10 reverses the effect of miR‐6838‐5p overexpression on breast cancer cell proliferation and angiogenesis. In addition, circ_0001667 interference also reduced breast cancer tumor growth in vivo. Conclusion Circ_0001667 is involved in breast cancer cell proliferation and angiogenesis through regulation of the miR‐6838‐5p/CXCL10 axis
LncRNA CERS6-AS1, sponging miR-6838-5p, promotes proliferation and invasion in cervical carcinoma cells by upregulating FOXP2
Get PDFCervical cancer (CC) is a common disease in
women characterized by high recurrence rate. LncRNA
ceramide synthase 6 antisense RNA 1 (CERS6-AS1) has
been found to play a crucial role in the progression of
breast cancer and pancreatic cancer. Nevertheless, the
regulatory role of CERS6-AS1 in CC remains largely
unclear. Here, we found that the expression of CERS6-
AS1 was upregulated in CC tissues and cell lines
compared with adjacent tissues and normal human
cervical epithelial cells. CERS6-AS1 overexpression
promoted proliferation and invasion, and inhibited
apoptosis in CC cells, while silencing of CERS6-AS1
led to the opposite results. CERS6-AS1 was verified as a
sponge of miR-6838-5p by RNA pull-down and
luciferase reporter gene assays. Functional investigations
revealed that CERS6-AS1 knockdown inhibited
proliferation and invasion, and promoted apoptosis in
CC cells, which was reversed by miR-6838-5p inhibitor.
Furthermore, forkhead box P2 (FOXP2) was identified
as a target for miR-6838-5p, and overexpression of miR6838-5p decreased the expression level of FOXP2.
Besides, CERS6-AS1 was able to sponge miR-6838-5p
to accelerate CC cell proliferation and invasion and
inhibited cell apoptosis through upregulating FOXP2
expression. In general, CERS6-AS1 was able to regulate
CC cell proliferation, invasion and apoptosis by the
miR-6838-5p/FOXP2 axis, which suggested that
CERS6-AS1 may be a potential target for the treatment
of CC
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Inventaire de l'orfèvrerie et des joyaux de Louis I, duc d'Anjou;
No full textTranscribed from manuscript Bibl. nat., nouv. acq. franç. 6838 for the Ministère de l'instruction publique.Introduction, issued 1906, bound as vol. 4.Mode of access: Internet
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