1,724,139 research outputs found
Certidão de Julgamento - Processo STJ n. 6744/03
No full textTrata de aposentadoria por doença grave. Processo n. 6744/2003. Julgado em 26/8/2004
H<scp>I</scp> Study of the NGC 6744 System
No full textAbstractWe present the preliminary results of our 5-configuration, 20-pointing mosaic with the Australia Telescope Compact Array of the neutral hydrogen in the nearby spiral galaxy NGC 6744. The bulk of the HI resides in a ‘ring’ underlying the outer optical disk, with 2 HI spiral arms extending further out to almost 1·5 optical radii. The velocity field is fairly regular, apart from evidence for streaming motions along the HI arms, and the influence of the companion IB(s)m galaxy NGC 6744A. We associate a cloud of HI at a heliocentric velocity of 846 km s−1 with another companion object, ESO 104–g44. Our attempts to construct a mass model for NGC 6744 suffer from poor resolution in the inner disk, and the uncertainty in the total HI flux of NGC 6744. We anticipate that HIPASS observations will be crucial in resolving the latter issue.</jats:p
Elucidation of microRNA miR-6744-5p regulation of anoikis in breast cancer cell lines and potential for therapeutic applications / Sharan Malagobadan
Get PDFAnoikis is apoptosis induced when cells are detached from the extracellular matrix and neighbouring cells. Since anoikis serves as a regulatory barrier, cancer cells often acquire resistance towards anoikis during tumorigenesis to become metastatic. MicroRNAs (miRNAs) are short strand of RNA molecules regulating genes post-transcriptionally, by binding to mRNAs and reducing the expression of its target genes. This study aims to elucidate the role of a novel miRNA, miR-6744-5p, in regulating anoikis in breast cancer and identify its target gene. Anoikis resistant variant of luminal A type breast cancer MCF-7 cell line (MCF-7-AR) was generated by selecting and amplifying surviving cells after repeated exposure to growth in suspension. miRNA microarray revealed a list of dysregulated miRNAs, from which miR-6744-5p was chosen for overexpression and knockdown studies. In MCF-7, overexpression of miR-6744-5p increased anoikis as shown by viability and caspase-3/7 activity assay, inhibited cell migration as shown by wound healing assay and increased E-cadherin expression as shown by Western blotting. Knockdown of miR-6744-5p decreased anoikis, increased cell migration and decreased E-cadherin expression. In the invasive triple-negative breast cancer cell line MDA-MB-231, overexpression of miR-6744-5p promoted anoikis and inhibited cell migration but knockdown of miR-6744-5p produced no effect. Additionally, overexpression of miR-6744-5p also induced morphological changes of MDA-MB-231 cells and inhibited invasiveness of the cells in vitro in transwell invasion assay and in vivo in zebrafish larva metastasis model. Furthermore, N-acetyltransferase 1 (NAT1) has been identified and validated as the direct target of miR-6744-5p using luciferase reporter assay and western blot. Overall, this study has proven the ability of miR-6744-5p to increase anoikis in both luminal A and triple negative breast cancer cell lines, highlighting its therapeutic potential in treating breast cancer
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A multi-frequency study of the Milky Way-like Spiral Galaxy NGC 6744
No full textWe present a multi-frequency study of the intermediate spiral SAB(r)bc type galaxy NGC 6744, using available data from the Chandra X-Ray telescope, radio continuum data from the Australia Telescope Compact Array and Murchison Widefield Array, and Wide-field Infrared Survey Explorer infrared observations. We identify 117 X-ray sources and 280 radio sources. Of these, we find nine sources in common between the X-ray and radio catalogues, one of which is a faint central black hole with a bolometric radio luminosity similar to the Milky Way’s central black hole. We classify 5 objects as supernova remnant (SNR) candidates, 2 objects as likely SNRs, 17 as H II regions, 1 source as an AGN; the remaining 255 radio sources are categorised as background objects and one X-ray source is classified as a foreground star. We find the star-formation rate (SFR) of NGC 6744 to be in the range 2.8–4.7 Mʘ yr−1 signifying the galaxy is still actively forming stars. The specific SFR of NGC 6744 is greater than that of late-type spirals such as the Milky Way, but considerably less that that of a typical starburst galaxy
A Multi-Frequency Study of the Milky Way-Like Spiral Galaxy NGC 6744
No full textWe present a multi-frequency study of the intermediate spiral SAB(r)bc type galaxy NGC 6744, using available data from the Chandra X-Ray telescope, radio continuum data from the Australia Telescope Compact Array and Murchison Widefield Array, and Wide-field Infrared Survey Explorer infrared observations. We identify 117 X-ray sources and 280 radio sources. Of these, we find nine sources in common between the X-ray and radio catalogues, one of which is a faint central black hole with a bolometric radio luminosity similar to the Milky Way’s central black hole. We classify 5 objects as supernova remnant (SNR) candidates, 2 objects as likely SNRs, 17 as H ii regions, 1 source as an AGN; the remaining 255 radio sources are categorised as background objects and one X-ray source is classified as a foreground star. We find the star-formation rate (SFR) of NGC 6744 to be in the range 2.8–4.7 M⊙~yr − 1 signifying the galaxy is still actively forming stars. The specific SFR of NGC 6744 is greater than that of late-type spirals such as the Milky Way, but considerably less that that of a typical starburst galaxy.ADK acknowledges the financial support from the ARC Centre of
Excellence for All-Sky Astrophysics (CAASTRO) through project
number CE110001020. MZP acknowledges support from the
Ministry of Education, Science and Technological Development of
the Republic of Serbia through project No. 176005
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