1,722,944 research outputs found
miR-6402 targets Bmpr2 and negatively regulates mouse adipogenesis
No full textObesity is characterized by macrophage infiltration into adipose tissue. White adipose tissue remodelling under inflammatory conditions involves both hypertrophy and adipogenesis and is regulated by transcription factors, which are influenced by bone morphogenetic protein (BMP) signalling. MicroRNAs (miRNAs) regulate gene expression and are involved in obesity-related processes such as adipogenesis. Therefore, we identified differentially expressed miRNAs in the epididymal white adipose tissue (eWAT) of mice fed a normal diet (ND) and those fed a high-fat diet (HFD). The expression of miR-6402 was significantly suppressed in the inflamed eWAT of HFD-fed mice than in ND-fed mice. Furthermore, Bmpr2, the receptor for BMP4, was identified as a target gene of miR-6402. Consistently, miR-6402 was downregulated in the inflamed eWAT of HFD-fed mice and in 3T3-L1 cells (preadipocytes) and differentiated 3T3-L1 cells (mature adipocytes) , and BMPR2 expression in these cells was upregulated. Adipogenesis was induced in WAT by BMP4 injection (in vivo) and in 3T3-L1 cells by BMP4 stimulation (in vitro), both of which were inhibited by miR-6402 transfection. Inflamed eWAT showed higher expression of BMPR2 and the adipogenesis markers C/EBPβ and PPARγ, which was suppressed by miR-6402 transfection. Our findings suggest that miR-6402 is a novel anti-adipogenic miRNA that combats obesity by inhibiting the BMP4/BMPR2 signalling pathway and subsequently reducing adipose tissue expansion
C.N.R. steam engine #6402 with passenger cars, unknown location
No full textHandwritten on back: "CNR Engine #6402 Passenger Train"
6402
No full textLa transformación social de un territorio pasa por el reconocimiento de su historia, por la construcción colectiva de memoria, por el respeto por la identidad, la cultura y los imaginarios sociales que pueden entrar en disputa constantemente con las verdades institucionales. De esta manera, la obra 6402, es una reinterpretación gráfica que toma como inspiración distintas estéticas de movimientos de arte, y pone en evidencia un número que, para la transformación social de los pueblos en Colombia, jamás se debería olvidar. El uso del recurso y referente estético de diversas épocas genera tensiones sociales y artísticas que se circunscriben en los imaginarios sociales y las diversas formas de representación. En esencia, esta obra es un grito de no olvido, con sensaciones cotidianas frente al devenir propio de la cultura
The realism of models in plant demography
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6402.pdf (Publisher’s version ) (Open Access
California Poll: 6402 -- March 23-28, 1964
No full textThe Field Poll, established in 1945 as The California Poll by Mervin Field, has operated continuously as an independent, non-partisan, media-sponsored public opinion news service. Each year the Field Polls cover a wide range of political and social topics examining California public opinion. Continuing measures are made of voter support for leading political figures vying for major state and federal offices, job ratings of important political figures and reactions to significant political events. Voter awareness, understanding and predispositions of major campaign issues and salient statewide ballot propositions are also tracked over time. For poll 6402 N=1196
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
HST Observations of the Globular Cluster NGC 6402 (M14) and Its Peculiar Multiple Populations
Get PDFWe present Hubble Space Telescope (HST) photometric results for NGC 6402, a highly reddened, very luminous Galactic globular cluster (GC). Recent spectroscopic observations of its red giant stars have shown a quite peculiar behavior in the chemistry of its multiple populations. These results have prompted UV and optical HST observations aimed at obtaining the cluster's "chromosome map" (ChM), an efficient tool for classifying GCs and characterizing their multiple populations. We find that the discontinuity in the abundance distributions of O, Mg, Al, and Na inferred from spectroscopy is more nuanced in the ChM, which is mostly sensitive to nitrogen. Nevertheless, photometry in optical bands reveals a double main sequence, indicating a discontinuity in the helium content of the populations. The population with the largest chemical anomalies (extreme) peaks at a helium mass fraction Y similar to 0.31. This helium content is consistent with results from the analysis of the distribution of horizontal branch stars and the spectrophotometry of the red giants. The ChM and the color-magnitude diagrams are compared with those of NGC 2808, a prototype GC with helium abundances up to Y greater than or similar to 0.35, and both confirm that NGC 6402 does not host stellar populations with such extreme helium content. Further, the ChM reveals the presence of a group of stars with higher metallicity, thus indicating that NGC 6402 is a Type II cluster. The modalities of formation of the multiple populations in NGC 6402 are briefly surveyed, with main attention on the asymptotic giant branch and supermassive star models, and on possible cluster merging
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