1,752,924 research outputs found
MicroRNA-629-5p promotes osteosarcoma proliferation and migration by targeting caveolin 1
No full textOsteosarcoma is a highly malignant tumor that occurs in the bone. Previous studies have shown that multiple microRNAs (miRNAs) regulate the development of osteosarcoma. This study aimed to explore the role of miR-629-5p and its target gene, caveolin 1 (CAV1), in osteosarcoma development. To analyze the expression of miR-629-5p and CAV1 mRNA in osteosarcoma tissues and cell lines, qRT-PCR analysis was performed. Dual-luciferase reporter experiments were subsequently performed to validate the relationship between CAV1 and miR-629-5p. CCK8 assay was used to measure osteosarcoma cell proliferation, and wound-healing assay was performed to study their migratory phenotype. Our findings revealed that miR-629-5p was overexpressed in osteosarcoma tissues and cells, and thereby enhanced cell proliferation and migration. Further, we validated that miR-629-5p targets CAV1 mRNA directly. CAV1 expression, which was negatively correlated with miR-629-5p expression, was found to be downregulated in osteosarcoma tissue samples. Moreover, our data showed that an increase in CAV1 level led to a decline in osteosarcoma cell proliferation and migration, which could be rescued by miR-629-5p upregulation. Overall, our study confirmed that miR-629-5p promoted osteosarcoma proliferation and migration by directly inhibiting CAV1.</div
Resolución UNRN N° 629/2009. Otorga equivalencia. No otorgar equivalencia.
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 629/2009. Otorga equivalencia. No otorgar equivalencia.fals
DataSheet_1_MiR-629-5p Promotes Prostate Cancer Development and Metastasis by Targeting AKAP13.zip
No full textProstate cancer (PCa) has become the most frequently occurring cancer among western men according to the latest report, and patients’ prognosis is often poor in the event of tumor progression, therefore, many researches are devoted to exploring the molecular mechanism of PCa metastasis. MicroRNAs (miRNA) have proved to play an important role in this process. In present study, by combining clinical samples with public databases, we found that miR-629-5p increased to varying degrees in primary localized PCa tissues and metastatic PCa tissues compared with adjacent normal tissues, and bioinformatics analysis suggested that high level of miR-629-5p was related to poor prognosis. Functionally, miR-629-5p drove PCa cell proliferation, migration and invasion in vitro, and promoted growth of PCa cells in vivo. Moreover, A-kinase Anchor Protein 13 (AKAP13) was screened as a direct target of miR-629-5p, that expression was negatively correlated with the malignant phenotype of tumor cells. In the end, through verification in clinical specimens, we found that AKAP13 could be independently used as a clinical prognostic indicator. Overall, the present study indicates that miR-629-5p plays an oncogenic role in PCa by targeting AKAP13, which provides a new idea for clinical diagnosis and treatment of complex refractory PCa.</p
Verlustliste Nr. 629. (Nr. 629. /1917)
No full textVERLUSTLISTE NR. 629.
Verlustliste (-)
Verlustliste Nr. 629. (Nr. 629. /1917) ([1])
Belehrung. (2)
Offiziere. (3)
A, B, C, D, E, F, G, H, I, J, K, L, M, N, P, R (3)
S (3)
T, V, W (4)
Einjährig-Freiwillige. (4)
A, B, C, D, E, G, H, K, L, M, N, O (4)
P (4)
R, S, U, V, W, Z (5)
Mannschaft. (5)
A (5)
B (6)
C (13)
D (14)
E (17)
F (18)
G (20)
H (22)
I (24)
J (25)
K (27)
L (35)
M (37)
N (41)
O (43)
P (44)
R (50)
S (52)
T (56)
U (56)
V (57)
W (59)
Z (61)
Ergänzungen zu den Verlustlisten: (63)
Nr. 83. Nr. 213. Nr. 284. (63)
Berichtigungen zu den Verlustlisten: (63)
Nr. 150. Nr. 154. Nr. 282. Nr. 388. Nr. 453. Nr. 483. Nr. 502. Nr. 506. Nr. 509. Nr. 549. Nr. 574. (63)
Berichtigungen bereits veröffentlichter, jedoch nicht legal nachweisbarer Todesfälle. (63)
Nr. 318. (63
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Regular festival (SAG.US), tablet concordance KUB XXV 27 - CTH 629
No full textTranscription of the tablet concordance KUB XXV 27 (inventory no. Bo 707) related to regular festival (SAG.US). Emmanuel Laroche translated this text as "Fête 'régulière' (SAG.US),” and classified in the category of texts of festivals and cults among diverse festivals (Catalogue des textes Hittites, No. 629).Paper (1 sheet
Regular festival (SAG.US), tablet concordance KUB XXV 27 - CTH 629
No full textTranscription of the tablet concordance KUB XXV 27 (inventory no. Bo 707) related to regular festival (SAG.US). Emmanuel Laroche translated this text as "Fête 'régulière' (SAG.US),” and classified in the category of texts of festivals and cults among diverse festivals (Catalogue des textes Hittites, No. 629).Paper (1 sheet
Resolución UNRN Nº 629/2011. Modifica la Resolución UNRN Nº 46/2008.
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN Nº 629/2011. Modifica la Resolución UNRN Nº 46/2008 en lo relativo a la denominación de la carrera y título, la propuesta curricular y los alcances partiendo de cuatro títulos diferenciados por nivel de enseñanza para el cual sea habilitado junto con los parámetros para su gestión en la modalidad a distancia de acuerdo con lo previsto en la Resolución ME 1717/04fals
El Tlacuache Núm. 629 (2014). 629 Año 13 (2014) julio. El Tlacuache
No full textTrayectorias laborales de inmigrantes en Morelos. El caso de los Mixtecos de Guerrero y Oaxaca asentados en la región Centro-Oriente por Adriana Saldaña Ramírez. Antes el pueblo mandaba. De la autonomía a la presencia del estado por Marco Antonio Tafolla Soriano
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