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[Camp Mfg. Co., Engine Drawing Card, Sketch No. 6179]
No full textThis engine drawing card was created for Camp Manufacturing Company, Class 10-20 1/4 D. Section H-10 1/4 D. Sketch 6179. Copy Spec. C-2431
Aktueller Forschungsschwerpunkt : Sprachverstehen
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6179.pdf (Publisher’s version ) (Open Access
Provision of FOLE or SEFA-6179 to mice receiving a fat-free high carbohydrate diet prevents hepatosteatosis.
No full text6-week-old male C57Bl6/J mice received an ad lib liquid fat-free high carbohydrate diet (HCD) with every other day orogastric gavage of saline, medium-chain triglyceride vehicle (MCT), fish oil lipid emulsion (FOLE), or SEFA-6179 (in MCT vehicle) at a low or high dose (A, created with biorender.com). Compared to chow, mice receiving saline or MCT lost weight (B, C); SEFA-6179 treatment did not change weight compared to MCT. SEFA-6179 treatment resulted in a dose-dependent increase in normalized liver weight and kidney weight, but not spleen weight, compared to MCT (D-F). Mice receiving the HCD developed increased serum alanine aminotransferase levels, with decreased levels in the FOLE and SEFA-6179 groups, although this did not reach statistical significance. Mice receiving saline or MCT developed macrovesicular steatosis; treatment with FOLE or SEFA-6179 (low or high dose) prevented steatosis (G, H). Mean ± SEM. Comparisons versus chow: * P0.05 ** P0.01 *** P0.001. Comparisons versus MCT: † P0.05 †† P0.01 ††† P0.001.</p
SEFA-6179 increases complete oxidation and β-oxidation of oleic acid in Huh7 cells, but does not affect oleic acid uptake or lipogenesis.
No full textHuman hepatocytes (the hepatocyte-derived carcinoma cell line Huh7) were cultured in 96-well plates at 12000 cells/well (n = 6 wells/group in each experiment). After 24 h the cells were either untreated, or pretreated with 0.1% DMSO (negative control), 5 μM SEFA-6179 (in DMSO), or 10 μM SEFA-6179 (in DMSO). Treatment with SEFA-6179 increased complete oxidation of oleic acid and β-oxidation in a dose-dependent manner (A, B). Treatment with SEFA-6179 did not affect total oleic acid uptake or lipogenesis (C, D). Mean ± SEM. * P0.05 vs. negative control.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Treatment with SEFA-6179, compared to MCT vehicle, in mice receiving a high carbohydrate diet with intravenous saline or SOLE, results in prevention of steatosis.
No full textThe study design is shown in A. Compared to chow, treatment with saline/MCT, SOLE/MCT, or FOLE/MCT resulted in decreased body weight (B, C). SEFA-6179 treatment, compared to MCT vehicle, decreased body weight further in each group. Compared to chow, treatment with saline/MCT, SOLE/MCT, or FOLE/MCT decreased normalized liver, kidney, and spleen weight (D-F). Treatment with SEFA-6179, compared to MCT, increased normalized liver and kidney weight. Treatment with saline/MCT resulted in steatosis, which was reversed with SEFA-6179 treatment (G, H). Mean ± SEM, Comparisons versus chow: † P0.05 †† P0.01 ††† P0.001. SEFA-6179 compared to MCT within intravenous lipid emulsion groups marked by lines: * P0.05 ** P0.01 *** P0.001.</p
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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