1,720,970 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Phototriggered Transformation of Carboxylic Acids Using Cyclopropenones
Get PDFPhotochemical reaction is especially useful for elucidation of biomolecules’ functions and fine synthesis of polymer materials because the temporal and spatial control of the reaction is possible by controlled light irradiation. In this research, we improved efficiency of a photocatalytic activation reaction of cyclopropenone derivatives by substituent modification. The result was published in an international journal, Journal of Organic Chemistry. Additionally, we explored bioactivity of aminocyclopropenone which we have used as a photoreactive group, and found some aminocyclopropenones have cytotoxicity on cancer cells by disrupting nuclear structure formation. The result was published in an international journal, Cells.光反応は反応が起こるタイミング、空間を制御できることから、特定の条件下での生命現象の解明、高分子の精密合成に特に有用である。本研究では、独自に開発した、光触媒によりシクロプロペノンから高反応性化学種を発生させる反応の、より温和な条件での実現に成功し、国際誌(The Journal of Organic Chemistry)で発表を行った。また、光反応基として開発したアミノシクロプロペノンに関して、これまでその生理活性に関する報告は皆無だったが、細胞を用いた生理活性試験により、特定の構造をもつアミノシクロプロペノンが、がん細胞に対して毒性を示すことを見出し、国際誌(Cells)での発表を行った。研究課題/領域番号:20K15953, 研究期間(年度):2020-04-01 – 2022-03-31出典：研究課題「シクロプロぺノンの光反応を利用するカルボキシ基の自在な化学変換法の開発」課題番号20K15953
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20K15953/20K15953seika/）を加工して作成金沢大学新学術創成研究機構research repor
Development of novel phototriggered reactions and their application to biomolecule labeling
Get PDF本研究では申請者らが独自に合成法を確立した新規骨格の生理活性物質としての利用可能性開拓、及び物性を活かした新規有機化学反応の開発、分光分析的手法による検出法の開発を行い、それらの成果を統合し、疾患の診断および治療に有用な分子プローブ開発を行うことを目的とし研究を行った。生理活性物質については申請者が独自に開発した骨格を含む目的化合物の合成を達成し、細胞、動物レベルでの動態評価を行い、当該新規骨格を用いる医薬品化学に重要な知見を得た。また、反応開発については光のON/OFFで完全に反応の進行の制御が可能な新規反応開発に成功し、学会、論文発表を行った。In this research we have accomplished two types of project using highly strained molecules. First project was the development of novel bioactive compounds having highly strained structure. We have succeeded to synthesis the desired product and analysed its activity and biodistribution using nuclear medicine method. We have obtained some important information for the medicinal chemistry using the strained structures. Second project was the development of novel phototriggered reactions using highly strained molecules. We have succeeded to develop a phototriggered dehydration condensation whose progress is completely controllable by ON/OFF states of the light irradiation. The result was published in Org. Lett. 2017, 4912.研究課題/領域番号:16H06824, 研究期間(年度):2016-08-26 - 2018-03-31出典：研究課題「光励起によるin situ活性種生成を利用した新規反応及び生体分子標識法の開発」課題番号16H06824
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H06824/16H06824seika/）を加工して作成金沢大学新学術創成研究機構research repor
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Development of phototriggered reactions using strained molecules
Get PDF生体分子や機能性材料の化学修飾に有用な新規光反応開発に取り組んだ。
アミノシクロプロペノンとカルボン酸共存下光照射を行うことでカルボン酸にアミノシクロプロペノン由来の官能基が導入されたケトンを迅速に形成する反応の開発に成功した。本成果はJ. Org. Chem. 2018, 83, 13595にて論文発表を行った。また、穏和な条件でシクロプロペノンから高反応性のアルキンを生成するため、可視光応答性触媒を利用する新反応開発に成功した。本反応により従来適用できなかった不安定な基質共存下の反応が可能になった。本成果はOrg. Lett. 2019, 21, 4101にて論文発表を行った。We developed two kind of novel photochemical reactions that would be potentially useful for functionalization of biomolecules and polymer materials. First, we developed a phototriggered ketone formation reaction from an aminocyclopropenone and a carboxylic acid. The reaction efficiently proceeds under intense light irradiation. By the reaction, functional groups on the aminocyclopropenone are covalently connected with the carboxylic acid. The result was published in J. Org. Chem. 2018, 83, 13595. Second, we developed a phototriggered active alkyne generation reactions using visible light responsive photocatalysts. The reaction condition was effective to generate highly reactive ynamine and cyclooctyne, and the generated alkynes can be used for the chemical reactions without isolation. The conditions were compatible with a UV sensitive substrate which cannot tolerate a classical direct UV irradiation conditions. The result was published in Org. Lett. 2019, 21, 4101.研究課題/領域番号:18K14864, 研究期間(年度):2018-04-01 – 2020-03-31出典：「歪みを内包する化合物を用いる光活性化型反応の開発」研究成果報告書 課題番号18K14864
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K14864/18K14864seika/)を加工して作成金沢大学新学術創成研究機構research repor
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