1,721,005 research outputs found
遺伝子解析を含む心筋虚血再還流障害に対するエンドセリン受容体拮抗薬の影響
Full text linkラット28匹において全身麻酔下で開胸し動脈圧、左質圧、心拍数など記録できる状態で左冠動脈前下行枝を4.0絹糸にて閉塞し30分の虚血後に再灌流させた。その後生食投与群、0.15μg/100gのエンドセリン拮抗薬持続投与群、0.15μg/100gのエンドセリン拮抗薬とアルドステロン拮抗薬の持続同時投与群、4.5μg/100gの高濃度エンドセリン拮抗薬とアルドステロン拮抗薬の持続同時投与群に分けて再灌流後3時間、6時間さらに24時間後の血行動態を評価した。高濃度エンドセリン拮抗薬持続投与群で血圧の低下、心拍数の増加を認めたが、他群では有意な変化は認めなかった。しかしながら、左室拡張末期圧は低濃度エンドセリン拮抗薬とアルドステロン拮抗薬の持続投与群で全時間経過を通して有意に低かった。また麻酔、補液量は全群同じ状態であったが6時間以上の生存率は以下のようであった。生食群29%、高濃度エンドセリンとアルドステロン拮抗薬の持続投与群57%、低濃度エンドセリン持続投与群71%、低濃度エンドセリン拮抗薬とアルドステロン拮抗薬の持続投与群100%と有意な差が認められた。現時点ではエンドセリン拮抗薬とアルドステロン拮抗薬の併用がラット心筋虚血再灌流障害モデルにおいて左室拡張末期圧の改善効果をもたらすのか不明な点が多いが0.15μg/100gというごく低濃度のエンドセリン拮抗薬における左室拡張能の改善効果が明らかになり不整脈死、心不全死を予防することが明らかになった。研究課題/領域番号:16790412, 研究期間(年度):2004 – 2005出典：「遺伝子解析を含む心筋虚血再還流障害に対するエンドセリン受容体拮抗薬の影響」研究成果報告書 課題番号16790412
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16790412/)を加工して作成金沢大学附属病院research repor
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The Mechanisms of Adipose Tissue Derived Regenerative Cells for Ischemic Heart Failure
Full text link臨床研究（自己脂肪組織由来間質細胞を用いた再生医療に関する臨書研究～虚血性心不全に対して～）実施した際の臨床サンプルを用いて、再生細胞の特性解析、抗サイトカイン効果の解析を実施進めた。
マウスモデルを用いた検討では、虚血再灌流障害モデルマウスに対して、脂肪組織由来再生細胞投与による心機能改善効果とその機序について解析を進めた。再生細胞投与による炎症性サイトカインの上昇抑制効果とそのシグナルについても解析を進めた。
上記の結果の一部を、第80回日本循環器学会総会と第15回日本再生医療学会総会において発表した。The analysis of adipose tissue derived regenerative cell were performed in patients who underwent our clinical study entitled “The Effect of Autologous Adipose Tissue Derived Regenerative Cells to Ischemic Heart Failure Patient”. Part of the beneficial effects to improve the cardiac performance may be related with reduction of inflammatory cytokines such as IL-1B, TNF-A.Also we investigated the effect of adipose tissue derived regenerative cells to myocardial ischemia-reperfusion model mice. And the significant reduction of inflammatory cytokines and improved cardiac function were closely related with the infusion of regenerative cells.
Part of these findings were presented at The 80th Annual Scientific Meeting of Japanese Circulation Society and The 15th Congress of The Japanese Society for Regenerative Medicine.研究課題/領域番号:25461049, 研究期間(年度):2013-04-01 - 2016-03-31出典：研究課題「脂肪組織由来間質細胞による心筋再生医療の作用機序に関する研究」課題番号25461049
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461049/25461049seika/）を加工して作成金沢大学附属病院循環器内科research repor
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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