1,720,985 research outputs found
末端肥大症の成因における遺伝子的研究
Full text link腫瘍の発生にはいくつかの遺伝子異常が関与し、成長ホルモン産生下垂体腺腫の一部にG蛋白の遺伝子異常が報告されている。成長ホルモン過剰は成人において末端肥大症を引き起こし高血圧、糖尿病をはじめとする代謝異常より心血管病を引き起こすだけでなく悪性新生物の合併頻度も高く、この疾患における平均寿命も健康人に比して短い。われわれはこれまで成長ホルモン産生下垂体腺腫に対してはG蛋白遺伝子などの解析を行ったが、これらの異常は見いだせなかった。そこで、DNAマイクロアレイ法による機能解析より成長ホルモン産生下垂体腺腫の成因を検討することとした。
平成13年度のDNAマイクロアレイ法を用いた検討よりヒト非ホルモン産生下垂体腺腫と成長ホルモン産生細胞腺腫組織間で、いくつかの細胞内情報伝達系に関わる遺伝子の発現量に差を認めた。ヒト非ホルモン産生下垂体腺腫に比べ成長ホルモン産生細胞腺腫で発現の増加を認めた遺伝子はDLG-3,NOTCH1,RFC37,CTC85,RAD52,GRM1,NACHRA6,bystin, LCFであり、逆に低下していた遺伝子はCDKN2,CETP, IRF1,VLA4,DLK, WNT2,WNT10Bであった。平成14年度は、これらの遺伝子ひとつひとつについてmRNAの発現をノーザンブロット法でも検討した。マイクロアレイ法と同様、成長ホルモン産生細胞腺腫ではDLG-3,NOTCH1,RFC37,CTC85,RAD52,GRM1,NACHRA6,bystin, LCFのmRNAの発現増加が認められた。発現の低下していた遺伝子のひとつであるCDKN2のプロモーター領域のメチル化が他の下垂体腺腫においてみられることより、成長ホルモン産生細胞腺腫についてもCDKN2のプロモーター領域のメチル化の有無を検討したが認められなかった。研究課題/領域番号:13770630, 研究期間(年度):2001-2002出典：「末端肥大症の成因における遺伝子的研究」研究成果報告書 課題番号13770630
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（ https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-13770630/ ）を加工して作成金沢大学附属病院research repor
Telemonitoring system for diabetic patients using a mobile phone
Full text link糖尿病患者に携帯機器を用いた在宅健康サービス（携帯機器上で、毎日の体重、運動量（歩数）、血圧等のデータを送信してもらい 逆に生活指導をした。）を行い前向きオープン無作為比較試験にて評価した。在宅サービス介入群では医学的にも医療経済的にも有用と証明された。さらに携帯機器の高性能化に対応し、テレビ会議用システムを改良したBluetooth機能などを附随したスマートフォン対応遠隔診療用デバイスを作成し、それに伴う技術的問題や法的問題に対処した。We performed a randomized controlled study to evaluate the usefulness of telemonitoring system for diabetic patients using a mobile phone. The patients sent data of their body weight, amount of exercise, and blood pressure etc and received the guidance of nutrition and exercise. The present study demonstrated the usefulness of telemonitoring system for diabetic patients both economically and medically. We also developed novel type of telemonitoring system with TV monitor and Bluetooth function, by which patient’s data can be automatically transmitted. We also dealt with some technical and legal problems associated with the new system.研究課題/領域番号:25460743, 研究期間(年度):2013-04-01 - 2017-03-31出典：「地域医療における軽症糖尿病患者に対する在宅健康サービスの継続研究」研究成果報告書 課題番号25460743
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460743/25460743seika/）を加工して作成金沢大学国際基幹教育院GS教育系research repor
Research of telemonitoring system for diabetic patients in community health care
Full text link糖尿病患者に携帯機器を用いた在宅健康サービス(携帯機器上で、毎日の体重、運動量(歩数)、血圧等のデータを送信してもらい 逆に生活指導をした。)を行い前向きオープン無作為比較試験にて評価した。その結果、有意な体重減少(-0.8 kg)、 収 縮期血圧低下(-9mmHg)空腹時血糖値低下(-8mg/dl)、HbA1c低下(-0.4%)を認めた。8症例において薬剤の減量が可能であった。携帯機器を用いた在宅健康サービスの介入の医学的及び医療経済的の有用性が示された。We performed a randomized controlled study to evaluate the usefulness of telemonitoring system for diabetic patients using a mobile phone. The patients sent data of their body weight, amount of exercise, and blood pressure etc and received the guidance of nutrition and exercise. Body weight, systolic pressure, fasting plasma glucose level, and HbA1c were decreased significantly. In 8 cases, the amount of drugs could be reduced. The present study demonstrated the usefulness of telemonitoring system for diabetic patients.研究課題/領域番号:22590460, 研究期間(年度):2010-2012出典：研究課題「地域医療における軽症糖尿病患者に対する在宅健康サービスの構築」課題番号22590460
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590460/22590460seika/）を加工して作成research repor
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
生活習慣病における多機能携帯電話を用いた遠隔診療システムの構築
Full text link平成21年度から構築してきた生活習慣病における在宅健康サービス制度にAI(人工知能)、IT技術、Bluetooth機能を導入し、その有用性を検討した。
研究プロトコルを作成し、倫理委員会での承認を得て研究開始、プロトコル論文を発刊した。（Diabetes Ther. 2019 Mar 15. doi: 10.1007/s13300-019-0595-5）。AI栄養指導は、ひとによる従来通常栄養指導と同等に有用で、ひとの負担軽減という点で社会的に有用と考えられた。We introduced artificial intelligence, IT technology, and Bluetooth technology to telemedicine system for lifestyle-related disease which has been built since Heisei 21, and evaluated its usefulness. We made the study protocol and started the study with the approval of the ethics committee. We also published the medical paper regarding the study protocol（Diabetes Ther. 2019 Mar 15. doi: 10.1007/s13300-019-0595-5）. Nutrition guidance system by telemedicine using artificial intelligence is thought to be socially useful as nutrition guidance by human, reducing human burden.研究課題/領域番号:17K09199, 研究期間(年度):2017-04-01 - 2020-03-31出典：「生活習慣病における多機能携帯電話を用いた遠隔診療システムの構築」研究成果報告書 課題番号17K09199
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K09199/17K09199seika/)を加工して作成金沢大学国際基幹教育院GS教育系research repor
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
