1,723,409 research outputs found
Block Card 5714 Winona Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 5714 Winona Street (Toledo, Ohio) | Ranch houses | Ann Acres (Toledo, Ohio) | Greenwood Area (Toledo, Ohio) | West Toledo Area (Toledo, Ohio
ABCA4Variant c.5714+5G> A in trans with null alleles results in primary RPE damage
Get PDFPurpose: To determine the disease pathogenesis associated with the frequent ABCA4 variant c.5714+5G>A (p.[=,Glu1863Leufs*33]).Methods: Patient-derived photoreceptor precursor cells were generated to analyze the effect of c.5714+5G>A on splicing and perform a quantitative analysis of c.5714+5G>A products. Patients with c.5714+5G>A in trans with a null allele (i.e., c.5714+5G>A patients; n = 7) were compared with patients with two null alleles (i.e., double null patients; n = 11); with a special attention to the degree of RPE atrophy (area of definitely decreased autofluorescence and the degree of photoreceptor impairment (outer nuclear layer thickness and pattern electroretinography amplitude).Results: RT-PCR of mRNA from patient-derived photoreceptor precursor cells showed exon 40 and exon 39/40 deletion products, as well as the normal transcript. Quantification of products showed 52.4% normal and 47.6% mutant ABCA4 mRNA. Clinically, c.5714+5G>A patients displayed significantly better structural and functional preservation of photoreceptors (thicker outer nuclear layer, presence of tubulations, higher pattern electroretinography amplitude) than double null patients with similar degrees of RPE loss, whereas double null patients exhibited signs of extensive photoreceptor ,damage even in the areas with preserved RPE.Conclusions: The prototypical STGD1 sequence of events of primary RPE and secondary photoreceptor damage is congruous with c.5714+5G>A, but not the double null genotype, which implies different and genotype-dependent disease mechanisms. We hypothesize that the relative photoreceptor sparing in c.5714+5G>A patients results from the remaining function of the ABCA4 transporter originating from the normally spliced product, possibly by decreasing the direct bisretinoid toxicity on photoreceptor membranes
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Thirty years since the end of the Soviet Union and the Warsaw Pact: Myths and realities
No full textEsta exposición es un resultado del grupo de investigación 970844 "Estudios Rusos Complutenses (ERC): Lengua, Literatura, Cultura, Religión, Política y Sociedad" y del proyecto de investigación "Aglaya: Estrategias de innovación en mitocrítica cultural" (H2019/HUM-5714).Algunos de los relatos míticos de la Unión Soviética siguen vigentes treinta años después, como veremos en la exposición.Some of the mythical narratives related to the end of the Soviet Union are still in effect thirty years later, as we will see in the poster exhibition.Comunidad de MadridDepto. de Filología Alemana y Filología EslavaFac. de FilologíaFALSEunpu
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
[Tonopah & Tidewater, Locomotive 4, Erecting Card Drawing No. 5714]
No full textErecting card drawing for Tonopah & Tidewater.This erecting drawing was created for Tonopah & Tidewater Locomotive 4, Class 08-30 D 639. Erecting Card Drawing No. 5714. Index Number: 673A-19. For more technical details on this drawing, see Baldwin Erecting Drawings by Road Name: http://www.smu.edu/~/media/Site/libraries/degolyer/pdfs/BLW-EDWG-RoadName.pdf and/or Baldwin Erecting Drawings by Class Number: https://www.smu.edu/~/media/Site/libraries/degolyer/pdfs/BLW-EDWG-Class.pdf (Note: Search by Index Number or Erecting Card Number)
The time course of lexical access in speech production: A study of picture naming
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5714.pdf (Publisher’s version ) (Open Access
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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