1,725,615 research outputs found
MF 5609 Dyna-4 media potenza multiuso.
No full textMAD in campo al lavoro. MF 5609 Dyna-4 media potenza multiuso
Block Card 5609 Yermo Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 5609 Yermo Street (Toledo, Ohio) | Ranch houses | Perradot Subdivision (Toledo, Ohio) | Greenwood Area (Toledo, Ohio) | West Toledo Area (Toledo, Ohio
Comparison of SB 470, as enacted, and LCO 5609
No full text"May 22, 1996."; Discusses SB 470 as enacted and LCO 5609, which was Senate Amendment "B".; Harvested from the web on 1/31/1
Block Card 5609 West Rowland Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 5609 West Rowland Road (Toledo, Ohio) | Ranch houses | Rowland Meadows (Toledo, Ohio) | Greenwood Area (Toledo, Ohio) | West Toledo Area (Toledo, Ohio
Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7
No full textCDK7 has emerged
as an exciting target in oncology due to its roles
in two important processes that are misregulated in cancer cells:
cell cycle and transcription. This report describes the discovery
of SY-5609, a highly potent (sub-nM CDK7 Kd) and selective, orally available inhibitor of CDK7 that entered
the clinic in 2020 (ClinicalTrials.gov Identifier: NCT04247126). Structure-based design was leveraged to
obtain high selectivity (>4000-times the closest off target) and
slow
off-rate binding kinetics desirable for potent cellular activity.
Finally, incorporation of a phosphine oxide as an atypical hydrogen
bond acceptor helped provide the required potency and metabolic stability.
The development candidate SY-5609 displays potent inhibition
of CDK7 in cells and demonstrates strong efficacy in mouse xenograft
models when dosed as low as 2 mg/kg
Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7
No full textCDK7 has emerged
as an exciting target in oncology due to its roles
in two important processes that are misregulated in cancer cells:
cell cycle and transcription. This report describes the discovery
of SY-5609, a highly potent (sub-nM CDK7 Kd) and selective, orally available inhibitor of CDK7 that entered
the clinic in 2020 (ClinicalTrials.gov Identifier: NCT04247126). Structure-based design was leveraged to
obtain high selectivity (>4000-times the closest off target) and
slow
off-rate binding kinetics desirable for potent cellular activity.
Finally, incorporation of a phosphine oxide as an atypical hydrogen
bond acceptor helped provide the required potency and metabolic stability.
The development candidate SY-5609 displays potent inhibition
of CDK7 in cells and demonstrates strong efficacy in mouse xenograft
models when dosed as low as 2 mg/kg
Benito Conde, C. J. "Emulación cortesana y devoción en la promoción artística de María de Lazcano (1593-1664) en Guipúzcoa": Bilbao: Universidad del País Vasco-Euskal Herriko Uniberstsitatea, 2022, pp. 360
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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