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Goede raad over Gemeenschapsrecht (Nederland)
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5224 Tonnen - Drittel des Kölner Archivs geborgen
Die Bergungsarbeiten am Kölner Waidmarkt, wo am 3. März das Historische Archiv einstürzte, kommen schneller voran als gedacht. Gestern zog die Feuerwehr Zwischenbilanz: 5224 Tonnen Bauschutt wurden in 371 Lkw-Ladungen abtransportiert. Die Severinstraße ist nahezu komplett geräumt, in zwei bis drei Wochen könnte das U-Bahn-Bauwerk vom Schutt befreit, bis Ende Mai die Bergung oberhalb des Grundwasserspiegels abgeschlossen sein. Die Mitarbeiter des Erstversorgungszentrums des Historischen Archiv..
Millora de la carretera BV-5224, accés nord a Manlleu
L'objectiu del projecte és la millora general a nivell de traçat i ordenació d'accessos de la carretera BV-5224 entre els PK 1+000 i 2+000. Aquest tram de carretera és l'accés nord a Manlleu, tram que s'anirà consolidant com un dels accessos principals als polígons industrials de Manlleu Est. També caldrà estudiar l'entrega a l'entrada de la zona urban
Millora de la carretera BV-5224, accés nord a Manlleu
L'objectiu del projecte és la millora general a nivell de traçat i ordenació d'accessos de la carretera BV-5224 entre els PK 1+000 i 2+000. Aquest tram de carretera és l'accés nord a Manlleu, tram que s'anirà consolidant com un dels accessos principals als polígons industrials de Manlleu Est. També caldrà estudiar l'entrega a l'entrada de la zona urban
Going Beyond Counting First Authors in Author Co-citation Analysis
The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Millora de la carretera BV-5224, accés nord a Manlleu
L'objectiu del projecte és la millora general a nivell de traçat i ordenació d'accessos de la carretera BV-5224 entre els PK 1+000 i 2+000. Aquest tram de carretera és l'accés nord a Manlleu, tram que s'anirà consolidant com un dels accessos principals als polígons industrials de Manlleu Est. També caldrà estudiar l'entrega a l'entrada de la zona urban
OLFML2A is necessary for anti-triple negative breast cancer effect of selective activator protein‐1 inhibitor T-5224
Previous studies have shown that expression of activator protein-1 (AP-1) family is significantly elevated in triple-negative breast cancer (TNBC), compared with that in other breast cancer subtypes. Here we investigated the anti-tumor effect and mechanism of T-5224, an inhibitor of c-Fos/AP-1, on TNBC. We identified that T-5224 inhibited the proliferation, migration, and invasion of TNBC cells and resulted in an increase in apoptosis. Furthermore, we found that OLFML2A is a key regulatory protein acting downstream of AP-1 and is involved in T-5224-targeted AP-1 action. Multiple clinical databases online have identified that high OLFML2A level is associated with poor prognosis in TNBC patients. In summary, our experimental and bioinformatic studies indicated that OLFML2A is necessary for AP-1-overexpressing TNBC. These findings demonstrate that AP-1-overexpressing TNBC dependent on OLFML2A, and targeting both AP-1 and OLFML2A through T‐5224 may be a synergistic therapeutic strategy for this clinically challenging subset of breast cancer
Variations on the Author
“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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