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See 5201 [At work in garment factory]
No full textThis is the same image as #5201, only it is an enlargemen
Koopmans' Compendium van het staatsrecht. Deventer : Kluwer, 1992. XVII, 326 p.
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IGFBP-5201-218 stimulates Cdc42GAP aggregation and filopodia formation in migrating mesangial cells
No full textIGFBP-5201-218 stimulates Cdc42GAP aggregation and filopodia formation in migrating mesangial cells.BackgroundWe have previously shown that insulin-like growth factor-I (IGF-I) and IGF binding protein-5 (IGFBP-5) induce mesangial cell migration using separate stimulatory and effector pathways. The IGFBP-5 stimulatory pathway is mediated by the serine/threonine kinase IGFBP-5 receptor, which is activated by the carboxy-terminal peptide IGFBP-5201-218. In this study, we examined the direct effects of IGFBP-5201-218 on stimulatory and effector pathways that lead to a change in mesangial cell (MC) phenotype.MethodsRapid actin reorganization, formation of filopodia, and characterization of novel substratum attachment structures that develop during IGFBP-5–mediating migration were examined by light, immunofluorescence, and electron microscopy. Using a wounding assay, migration was measured after the addition of stimulants and inhibitors.ResultsStimulation of MCs with IGFBP-5201-218 induces rapid actin reorganization and loss of peripheral focal adhesions. The MCs develop long cellular extensions where f-actin and β-actin terminate in unique substratum attachments. Fluorescence microscopy of stimulated cells shows that Cdc42GAP aggregates within minutes following treatment with IGFBP-5201-218. In contrast, IGF-I increases staining for Rac-1, but not Cdc42GAP, in association with the formation of prominent leading lamellae without filopodia. Staurosporin inhibits cell migration and Cdc42GAP aggregation only when added within the first hour, suggesting that it inhibits the stimulatory effect of IGFBP-5201-218 by blocking the IGFBP-5 receptor serine/threonine kinase activity.ConclusionsThese data demonstrate that IGFBP-5201-218 preferentially activates Cdc42 and induces the formation of long filopodia with unique substratum attachments that produce a novel mode of locomotion
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Is BZB J1450+5201 the most distant gamma-ray BL Lacertae object?
No full textBL Lacertae (BL Lac) objects at high redshifts (z >= 2) are rarely detected. Through careful analysis of its Sloan Digital Sky Survey spectrum, BZB J1450+5201 is confirmed to be a high-z BL Lac object with z >= 2.471 by identifying the Ly alpha 1216 and CIV 1548/1550 absorption lines. This indicates that BZB J1450+5201 is the most distant BL Lac object discovered to date. Careful analysis of the five-year Fermi-LAT data of 2FGL J1451.0+5159 shows that its gamma-ray emission is robust with a confidence level of 6.2 sigma at 1-3 GeV and 6.7 sigma at 3-10 GeV. This analysis with the five-year data overcomes confusion with its bright neighbor, which is a problem when analyzing the two-year data. In addition, 2FGL J1451.0+5159 is confirmed to be associated with BZB J1450+5201 using the five-year data. The analysis of multiwavelength data, from radio to gamma-ray energies, indicates that BZB J1450+5201 is an intermediate synchrotron peaked (ISP) source. Its multiwavelength properties are consistent with distributions of other ISP sources at lower redshifts in the second Fermi-LAT AGN catalog. The pure synchrotron self-Compton (SSC) model seems to be disfavored, but the scattering of weak external emission plus the SSC process can provide a satisfactory description of the broadband emission
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Il diritto di riscatto riceve una tutela "effettiva" oltre il formalismo giuridico (nota a Cass. 17 marzo 2015, n. 5201)
No full textnota adesiva a Cass. 17 marzo 2015 n. 5201, in tema di riscatto agrari
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