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Erfahrungen mit BAY b 5097
No full textDie antimykotisdie Wirkung von BAY b 5097 wurde in vitro und in vivo untersucht. In vitro liegt die MIC 14 (minimale Hemmkonzentration nach 14tägiger Inkubation) nach der Röhrchen‐Verdünnungsmethode für Coccidioides immitis (4 Stämme), Clado‐sporium trichoides (1 Stamm), C. carrionii (1 Stamm), Phialophora compacta (1 Stamm), P. jeanselmei (1 Stamm), P. pedrosoi (1 Stamm) und Histoplasma duboisii (1 Stamm) zwischen 1 und 8 mcg pro ml. Für Cryptococcus neoformans (20 Stämme) liegen sie zwischen 5 und mehr als 10 mcg/ml. Die MIC 14 für vier Stämme Sporothrix schenckii liegt über 10 mcg/ml. Für Basidiobolus meristosporus (2 Stämme) liegt sie über 100 mcg/ml, für B. ranarum beträgt sie 1 mcg/ml für einen Stamm und über 100 meg für einen anderen Stamm. Die Versuche in vivo wurden mit Albinomäusen durchgeführt, die 7 Tage lang täglich 150 mg/kg BAY b 5097 erhielten. Bei der experimentellen Sporotrichose wich die Mortalitätskurve für die Versuchstiere von der Kurve für die Kontrolltiere ab, was einer gewissen Wirksamkeit von BAY b 5097 zuzuschreiben sein dürfte. Eine günstige therapeutische Wirkung von BAY b 5097 kam bei experimenteller Cocci‐dioidomykose in einer geringeren Frequenz bestimmter autopsisch festgestellter Schädi‐gungen zur Geltung. Bei experimenteller Cryptococcose war keine günstige Wirkung nachzuweisen. Bei Basidiolobomykose war eine gewisse Differenz zu erkennen, die in umfangreicheren Versuchen nachzuprüfen wäre. The antifungal activity of Bay b 5097 has been investigated in vitro and in vivo. The minimal inhibitory concentration after 14 days (MIC 14) in dilution tests for Coccidioides immitis (4 strains), Cladosporium trichoides (1 strain), C. carrionii (1 strain), Phialophora compacta (1 strain), P. jeanselmii (1 strain), P. pedrosoi (1 strain) and Histoplasma duboisii (1 strain) lies between 1 to 8 mcg per ml. The MIC 14 for Cryptococcus neoformans (20 strains) varies from 5 to 10 mcg/ml. For Sporothrix schenckii (4 strains) the MIC 14 is higher than 10 mcg/ml. Basidiobolus meristosporus (2 strains) shows a MIC 14 over 100 mcg/ml; for one strain of B. ranarum the MIC 14 is 1 mcg/ml, for another strain over 100 mcg/ml. In the “in vivo studies” white mice where orally treated with 150 mcg/kg Bay b 5097 for 7 days. In experimental sporotrichosis the antifungal activity is apparent only when the mortality curves of treated and control groups are compared. The therapeutic effect of Bay b 5097 in experimental coccidioidomycosis is apparent when the number of lesions and their extent at necropsy in treated and control animals are compared. No therapeutic effect could be detected in experimental cryptococcosis. The results obtained in experimental basidiobolomycosis need further investigations. 1975 Blackwell Verlag GmbHSCOPUS: ar.jinfo:eu-repo/semantics/publishe
Linked collectors and determiners for: Synopsis of the Neotropical Premnobiina (Coleoptera: Curculonidae: Scolytinae Ipini) with descriptions of new species, new synonymy and keys to species.
No full textNatural history specimen data linked to collectors and determiners held within, "Synopsis of the Neotropical Premnobiina (Coleoptera: Curculonidae: Scolytinae Ipini) with descriptions of new species, new synonymy and keys to species". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/8c89b0fc-5097-4808-9d90-e26c1b31c5ab">https://bionomia.net/dataset/8c89b0fc-5097-4808-9d90-e26c1b31c5ab</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/8c89b0fc-5097-4808-9d90-e26c1b31c5ab">https://gbif.org/dataset/8c89b0fc-5097-4808-9d90-e26c1b31c5ab</a>. Formatted as a Frictionless Data package
De godsdienstvrijheid en de brandbeveiliging
Get PDFContains fulltext :
5097.pdf (Publisher’s version ) (Open Access
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
PERBRONCHIAL INFUSION OF CLOTRIMAZOLE (BAY b 5097) IN A CASE OF PULMONARY ASPERGILLOMA
No full textこの論文は国立情報学研究所の学術雑誌公開支援事業により電子化されました。A case diagnosed as intrapulmonary aspergilloma on the basis of sputum culture, bronchial secretion culture, and chest X rays, was treated with BAY b 5097 orally and by perbronchial infusion. The case became negative for fungus ball for some time. The suspension consisted of 1 mg/ml BAY b 5097 in a mixture in equal volumes of glycerin and physiological saline solution was infused by means of Metras catheter at the segmental bronchus under fluoroscopic television. The infusion was performed twice within 3 weeks, with a total of 60 mg BAY b 5097. The fungus ball disappeared for some time but seems to have reappeared. Perbronchial infusion of BAY b 5097 could likely be of value, as an adjunct in the chemotherapy of intrapulmonary aspergillomas, if further investigations have established adequate dosage and frequency of administration
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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