1,720,983 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Impacts of Protein Quality Control in Cardiac Remodeling after Myocardial Infarction
Get PDF心不全の進展には、心筋細胞死・線維化といった心臓組織のリモデリングが深くかかわっている。骨格筋のサイズを制御する筋特異的ユビキチン連結酵素MAFbxは、心筋において生理的肥大や病的心肥大を制御することが明らかになった。本研究では、より複雑な要因の加わる心筋梗塞後リモデリングにおける役割を検証した。MAFbx遺伝子欠損マウスに心筋梗塞モデルを作成すると、心破裂による死亡が野生型マウスと比較して有意に減少した。MAFbxは心筋梗塞後に生じる心破裂を制御している可能性が示唆された。Left ventricular (LV) remodeling following myocardial infarction (MI) has an important role on global cardiac function. Muscle atrophy F-box (MAFbx), an E3 ubiquitin ligase, induces skeletal muscle atrophy and cardiac remodeling under the condition of pressure overload, but the roles of MAFbx in MI is not well understood. Our aim is to determine if MAFbx contribute to cardiac remodeling following MI. MAFbx-knockout (KO) and wild-type (WT) mice were subjected to permanent coronary ligation to create MI. The infarct sizes 3 days after MI were not significantly different in WT and MAFbx KO mice. In comparison with WT mice, MAFbx KO mice were protected against early mortality due to cardiac rupture. MMP9 activity in risk areas 3 days after MI was significantly reduced in KO mice than in WT mice.
MAFbx protein level increase in acute phase after MI. Gene deletion of MAFbx deletion reduces mortality after MI and cardiac rupture, decreasing the activity of MMP9.出典：研究課題「心筋梗塞後リモデリングにおけるタンパク質分解系の役割」課題番号24591092
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591092/24591092seika/）を加工して作成金沢大学附属病院循環器内科research repor
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Role of Muscle Atrophy F-box in the progression of Cardiac Remodeling
Get PDF心不全の病態形成における解析を行うために、マウスを用いて圧負荷誘導性の心肥大・心不全モデルの作成を行った。C57/B6マウスに、人工呼吸器管理下に横行大動脈に狭窄を作成した。術後2週で有意な左室肥大が、術後4週で肺うっ血を生じ心不全が起こることを確認した。筋特異的ユビキチン連結酵素MAFbxが、術後1週、2週と時間依存的にその発現レベルが有意に増加していくことを確認した。MAFbx欠損マウスに圧負荷モデルを作成し、MAFbx欠損マウスでは圧負荷による左室肥大は有意に抑制された。MAFbxは圧負荷に伴う心肥大および心臓リモデリングを制御している可能性が示唆された。研究課題/領域番号:20890085, 研究期間(年度):2008-2009出典：研究課題「筋特異的ユビキチン連結酵素MAFbxの不全心病態形成における役割の検討」課題番号20890085
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20890085/20890085seika/）を加工して作成金沢大学附属病院循環器内科research repor
Role of Protein Quality Control in Cardiac Remodeling
Get PDF心不全発症進展には心筋の肥大や細胞死(アポトーシス)といった心臓リモデリングの制御が深くかかわっている。今回我々は、骨格筋のサイズを制御する筋特異的ユビキチン連結酵素MAFbxの心臓リモデリングにおける役割の検討を行った。圧負荷モデル(大動脈縮窄モデル,イソプロテレノール持続投与)により誘導される心肥大および心機能低下は、MAFbx遺伝子欠損マウスでは、野生型マウスと比較して抑制されていた。種々の検討からMAFbx遺伝子欠損マウスでのリモデリング抑制効果にNF-κB経路の抑制が関与していることが明らかになった。MAFbxを制御することは病的心筋肥大を減じることにより、心不全への進展を抑制する可能性が示唆された。Under condition of increased hemodynamic load, cardiomyocytes undergo hypertrophy to adapt to increased work load and reduce wall stress. But, the prolonged existence of cardiac hypertrophy is an independent risk factor for cardiac morbidity and mortality. Here, we investigated the role of muscle atrophy F-box(MAFbx/atrogin-1), an E3 ubiquitin ligase, in regulating cardiac hypertrophy and function in response to pressure overload. Transverse aortic constriction(TAC)-andβ.-adrenergic-induced increases in cardiac hypertrophy and lung congestion were significantly smaller in MAFbx knockout(KO) than in wild-type(WT) mice. Downregulation of MAFbx inhibits cardiac hypertrophy in part through stabilization of I. B and inactivation of nuclea factor-. B. Inhibition of MAFbx attenuates pathological hypertrophy, thereby protecting the heart from progression into heart failure.研究課題/領域番号:22790697, 研究期間(年度):2010-2011出典：研究課題「タンパク質品質管理機構の心不全病態形成への関与」課題番号22790697
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22790697/22790697seika/）を加工して作成金沢大学附属病院循環器内科research repor
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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