1,720,977 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Clarification of Mechanism of Anti-microRNA-122 Therapy for Hepatitis C Virus Infection
Full text link今後C型慢性肝炎治療はDirect-Acting Antiviral Agents (DAA)耐性ウイルスが問題となる．今回肝特異的に発現するmicroRNA-122 (miR-122)を標的とした抗miR-122療法とDAA併用療法の有用性を検討した．その結果，DAAと抗miR-122療法の併用により相乗的な抗ウイルス効果を示し，DAA耐性ウイルスにDAAと抗miR-122療法を併用することでDAA耐性が改善し, DAAと抗miR-122療法併用によりDAA耐性ウイルスの出現を抑制した．これらの結果から DAAと抗miR-122療法併用は，DAA耐性ウイルスを抑制しうる点で有用と考えられた．The emergence of Direct-Acting Antiviral Agents (DAA)-resistant virus could be a serious problem for the treatment of chronic hepatitis C patients. We examined the efficiency of the combination therapy with DAA and anti-miR-122 therapy, which is targeting liver-specific miRNA, miR-122. We demonstrated that the combination therapy (1) shows synergistic antiviral effect, (2) alleviates the drug resistance of DAA-resistance viruses, and (3)completely inhibits the emergence of DAA-resistance virus. These results indicate that anti-miR-122 therapy is quite useful in terms of inhibiting the emergence of DAA-resistance virus when it is combined with DAA.研究課題/領域番号:24790687, 研究期間(年度):2012-04-01 - 2015-03-31出典：研究課題「抗microRNA122療法を基軸とした新規抗C型肝炎ウイルス治療法の開発」課題番号24790687
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790687/24790687seika/）を加工して作成金沢大学附属病院地域医療教育センターresearch repor
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Control of Chronic Liver Diseases due to Hepatitis C Virus by Long Non-coding RNAs
Full text link長鎖ノンコーディングRNAのC型肝炎ウイルス（HCV)感染における役割を明らかにするため研究を実施した。HCV感染培養細胞のRNAを次世代シークエンサーで解析した所、長鎖ノンコーディングRNAの一つHULCの発現がHCV感染により増加することが明らかになった。HCV感染によるHULCの増加は、HCV感染チンパンジー、HCV感染マウスモデルでも認められた。またHCV感染培養肝細胞でHULCの発現を抑制したところHCV複製の低下を認め、この効果はHCVの翻訳過程の抑制を介していると考えられた。HULCは肝発癌の関与が示唆されており、HCVはHULCの発現を増加し肝発癌を誘発していると考えられた。We investigated the role of long non-coding RNAs in HCV infection. The analysis on RNA of HCV-infected cultured hepatocytes by a next generation sequencer revealed that the RNA level of one of long non-coding RNAs, HULC, increased. The increase of HULC RNA level was observed not only in HCV-infected cultured hepatocytes, but also in an HCV-infected chimpanzee and a HCV-infected mouse. The knockdown of HCV by siRNA suppressed HCV replication as well as infectious virus production in HCV-infected cultured hepatocytes. This effect seemed to occur through the suppression of a translation step among HCV life cycles. Several recent reports show that HULC has the ability to promote hepatocarcinogenesis, therefore, the result of this study suggests a mechanism of hepatocarcinogesis due to HCV infection through HULC.研究課題/領域番号:15K08492, 研究期間(年度):2015-04-01 - 2018-03-31出典：研究課題「長鎖ノンコーディングRNAを基軸としたC型慢性肝疾患の病態制御」課題番号15K08492
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08492/15K08492seika/）を加工して作成金沢大学附属病院地域医療教育センターresearch repor
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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