1,726,098 research outputs found
miR-4793-3p predicts poor prognosis and regulates ferroptosis and invasiveness of breast cancer via targeting RNF169
No full textAbstract Background The prognosis prediction of breast cancer is a challenging problem in the clinic. Identifying reliable biomarkers and revealing the regulatory mechanism underlying the progression of breast cancer cells would benefit the treatment and outcomes of breast cancer patients. Objectives This study aims to explore a novel biomarker related with tumor progression and clinical prognosis, focusing on miR-4793-3p and its targets. Materials and methods The study enrolled 133 patients with breast cancer, and tissue samples were obtained. Expression of miR-4793-3p and its clinical significance were evaluated from the perspective of molecular subtypes, disease development, and prognosis. The regulatory effect and mechanism of miR-4793-3p in the biological function of breast cancer cells were assessed. Results Significant downregulation of miR-4793-3p was observed in tumor tissues of patients with breast cancer, and lower miR-4793-3p levels were found in patients with more malignant subtypes. miR-4793-3p was closely associated with the differentiation, TNM stage, lymph node metastasis, subtypes, and poor prognosis of patients and was identified as an independent prognostic factor. miR-4793-3p significantly suppressed cell growth, metastatic potential, and promoted ferroptosis of breast cancer, and the negative regulation of RNF169 was revealed to mediate the function of miR-4793-3p. JAK2/STAT3 signaling was suppressed by miR-4793-3p, which suppressed cell growth and metastatic potential and promoted ferroptosis. Conclusion miR-4793-3p could act as a biomarker for breast cancer, indicating cancer development and predicting patients’ outcomes. miR-4793-3p modulated ferroptosis and therefore regulated tumor progression via suppressing JAK2/STAT3 signaling by targeting RNF169
Linked collectors and determiners for: NINA insect database.
No full textNatural history specimen data linked to collectors and determiners held within, "NINA insect database". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/346a9b13-5c96-4793-bcd7-d6614950e726">https://bionomia.net/dataset/346a9b13-5c96-4793-bcd7-d6614950e726</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/346a9b13-5c96-4793-bcd7-d6614950e726">https://gbif.org/dataset/346a9b13-5c96-4793-bcd7-d6614950e726</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: NINA insect database.
No full textNatural history specimen data linked to collectors and determiners held within, "NINA insect database". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/346a9b13-5c96-4793-bcd7-d6614950e726">https://bionomia.net/dataset/346a9b13-5c96-4793-bcd7-d6614950e726</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/346a9b13-5c96-4793-bcd7-d6614950e726">https://gbif.org/dataset/346a9b13-5c96-4793-bcd7-d6614950e726</a>. Formatted as a Frictionless Data package
Broeksriem en bretellen : Medisch jargon in Nederland en Vlaanderen
Get PDFContains fulltext :
4793.pdf (Publisher’s version ) (Open Access
Linked collectors and determiners for: Additions and corrections to the systematics of mayfly species assigned to the genus Callibaetis Eaton 1881 (Ephemeroptera: Baetidae) from South America.
No full textNatural history specimen data linked to collectors and determiners held within, "Additions and corrections to the systematics of mayfly species assigned to the genus Callibaetis Eaton 1881 (Ephemeroptera: Baetidae) from South America". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/fb0a7416-8d2e-4793-9dc3-525ffccb9e62">https://bionomia.net/dataset/fb0a7416-8d2e-4793-9dc3-525ffccb9e62</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/fb0a7416-8d2e-4793-9dc3-525ffccb9e62">https://gbif.org/dataset/fb0a7416-8d2e-4793-9dc3-525ffccb9e62</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: INHS wet collections accession.
No full textNatural history specimen data linked to collectors and determiners held within, "INHS wet collections accession". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/ceac3273-94ef-4793-9789-fb8154d43436">https://bionomia.net/dataset/ceac3273-94ef-4793-9789-fb8154d43436</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/ceac3273-94ef-4793-9789-fb8154d43436">https://gbif.org/dataset/ceac3273-94ef-4793-9789-fb8154d43436</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Re-collection and identity of Ooencyrtus californicus (Hymenoptera: Encyrtidae) and its new synonym, Ooencyrtus lucidus.
No full textNatural history specimen data linked to collectors and determiners held within, "Re-collection and identity of Ooencyrtus californicus (Hymenoptera: Encyrtidae) and its new synonym, Ooencyrtus lucidus". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/073294fe-ca59-4793-b7d6-a554a7d72be6">https://bionomia.net/dataset/073294fe-ca59-4793-b7d6-a554a7d72be6</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/073294fe-ca59-4793-b7d6-a554a7d72be6">https://gbif.org/dataset/073294fe-ca59-4793-b7d6-a554a7d72be6</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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