1,724,805 research outputs found
Indian Creek Ripple
No full textMSS B 540 Civilian Conservation Corps Newsletters, 1935-1941Newsletters of Company 4776, 193
Block Card 4776 Glenbrier Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Garrison Colonial Style | 4776 Glenbrier Road (Toledo, Ohio) | Dwelling | Glendale Hills (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Linked collectors and determiners for: Canadian National Mycological Herbarium.
No full textNatural history specimen data linked to collectors and determiners held within, "Canadian National Mycological Herbarium". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/695cef75-b65f-4776-b2ed-74565eebb16e">https://bionomia.net/dataset/695cef75-b65f-4776-b2ed-74565eebb16e</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/695cef75-b65f-4776-b2ed-74565eebb16e">https://gbif.org/dataset/695cef75-b65f-4776-b2ed-74565eebb16e</a>. Formatted as a Frictionless Data package
Roles of tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, platelet-activating factor, and arachidonic acid metabolites in interleukin-1-induced resistance to infection in neutropenic mice
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4776.pdf (Publisher’s version ) (Open Access
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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Abstract 4776: NRF2 is overexpressed in esophageal adenocarcinoma and its targeting sensitizes tumor cells to cisplatin through induction of ferroptosis and apoptosis
No full textAbstract Background: Esophageal adenocarcinoma (EAC) is the predominant type of esophageal cancer in the United States, with the 5-year survival rate is below 20%. EAC develops through Barrett’s esophagus (BE)-dysplasia-carcinoma cascade. Gastroesophageal reflux disease (GERD), where acidic bile salts refluxate into the esophagus, is the main risk factor for the development of BE and its progression to EAC. The NFE2-related factor 2 (NRF2) is the master cellular antioxidant regulator, involving in many cancer hallmarks. Methods and Results: Using western blotting and immunohistochemistry technologies, we detected high NRF2 protein levels in EAC cell lines and primary EAC tissues, as compared with normal esophagus and non-neoplastic Barrett’s esophagus samples. The knockdown of NRF2 using NRF2 specific siRNAs significantly increased oxidative stress in response to cellular stress stimuli by bile salts or cisplatin. This was associated with an increase in DNA damage and inhibition of EAC cell growth. Brusatol, a NRF2 inhibitor, significantly inhibited NRF2 transcriptional activity and downregulated NRF2 target genes. We discovered that in addition to inducing apoptosis, Brusatol alone or in combination with CDDP induced significant lipid peroxidation and ferroptosis as evidenced by reduced xCT and GPX4 expression, two known ferroptosis markers. Moreover, the combination of Brusatol and CDDP significantly inhibited EAC tumor xenografts growth in vivo. We confirmed the in vitro data showing ferroptosis as an important mechanism in the xenografted tumors treated with Brusatol or Brusatol and CDDP combination using IHC staining. Conclusion: Our data support the role of NRF2 in protecting against stress-induced apoptosis and ferroptosis in EACs. Targeting NRF2 in combination with platinum therapy can be an effective strategy for eliminating cancer cells in EAC. Citation Format: Farah Ballout, Heng Lu, Zheng Chen, Tianling Hu, Lei Chen, Wael El-Rifai, Dunfa Peng. NRF2 is overexpressed in esophageal adenocarcinoma and its targeting sensitizes tumor cells to cisplatin through induction of ferroptosis and apoptosis. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4776
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Integrative multi-omics and preclinical analyses identify miR-4776-5p as a prognostic radiosensitizer for patients undergoing radiotherapy for head-and-neck cancer
No full textAbstract Radiotherapy remains a cornerstone treatment for head-and-neck cancer (HNC), yet resistance to radiation therapy significantly limits clinical outcomes. MicroRNAs (miRNAs) have emerged as promising regulators of radiosensitivity; however, the mechanisms by which miRNAs modulate radiosensitivity in HNC remain incompletely understood. In this study, we employed a multi-omics strategy integrating transcriptomic, clinical, and outcome data to investigate miRNA-associated radiosensitivity. Critically, we defined two distinct patient cohorts in the public dataset: one group received only radiotherapy, and the other did not receive radiotherapy. This stratification allowed us to conduct a unique comparative bioinformatics analysis, leading to the identification of miR-4776-5p as a candidate radiosensitizer. Elevated miR-4776-5p expression correlated with improved prognosis, specifically in patients receiving radiotherapy. Functional assays confirmed that miR-4776-5p sensitized FaDu HNC cells to radiation-induced DNA damage and impaired clonogenic survival. Mechanistic analyses demonstrated that miR-4776-5p modulates the cell cycle and DNA damage response pathways, enhancing tumor radiosensitivity. Furthermore, xenograft mouse models validated the radiosensitizing effects of miR-4776-5p in vivo, evidenced by significantly delayed tumor growth following irradiation. These findings highlight miR-4776-5p as a potential biomarker and therapeutic agent to improve radiotherapy efficacy in HNC, supporting further clinical exploration
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