1,726,063 research outputs found
Co-propagation of maser emission at 1720 and 4765 MHz
No full textMERLIN observations are presented of OH 4765-MHz and OH 1720-MHz masers in the massive star-forming region W3(OH). Two of the three intense spots of maser emission at 4765 MHz are spatially coincident with two similar spots at 1720 MHz in both left-hand circular (LHC) and right-hand circular (RHC) polarizations, to an accuracy of 15 mas. The spots also overlap in velocity when allowance is made for Zeeman splitting of the 1720-MHz line. We conclude that we have found two examples of masers in different rotational levels of OH which are co-propagating through the same column of gas and experiencing competitive gain effects. The third 4765-MHz maser spot was found to have no overlapping counterpart amongst the 1720-MHz masers
4765. Philippe de Vigneulles, chroniqueur messin
No full text4765. Philippe de Vigneulles, chroniqueur messin. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). V. Introduction générale - Les Valois (suite), Louis XI et Charles VIII (1461-1494) Paris : A. Picard et fils, 1904. pp. 51-52
4765. Philippe de Vigneulles, chroniqueur messin
No full text4765. Philippe de Vigneulles, chroniqueur messin. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). V. Introduction générale - Les Valois (suite), Louis XI et Charles VIII (1461-1494) Paris : A. Picard et fils, 1904. pp. 51-52
Linked collectors and determiners for: Luther Entomological Research Collection.
No full textNatural history specimen data linked to collectors and determiners held within, "Luther Entomological Research Collection". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/a0344d4c-1618-4765-9964-595269c8b334">https://bionomia.net/dataset/a0344d4c-1618-4765-9964-595269c8b334</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/a0344d4c-1618-4765-9964-595269c8b334">https://gbif.org/dataset/a0344d4c-1618-4765-9964-595269c8b334</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Graphium butterfly specimens at Museum Zoologi Bogor, Indonesia.
No full textNatural history specimen data linked to collectors and determiners held within, "Graphium butterfly specimens at Museum Zoologi Bogor, Indonesia". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/2aad3bc7-4765-40ea-b478-3ac3cb53ff72">https://bionomia.net/dataset/2aad3bc7-4765-40ea-b478-3ac3cb53ff72</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/2aad3bc7-4765-40ea-b478-3ac3cb53ff72">https://gbif.org/dataset/2aad3bc7-4765-40ea-b478-3ac3cb53ff72</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Redescription of Urophycis brasiliensis (Kaup 1858), a senior synonym of Urophycis latus Miranda Ribeiro 1903 (Gadiformes: Phycidae).
No full textNatural history specimen data linked to collectors and determiners held within, "Redescription of Urophycis brasiliensis (Kaup 1858), a senior synonym of Urophycis latus Miranda Ribeiro 1903 (Gadiformes: Phycidae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/740eba2d-27da-4765-8559-74e357162f7f">https://bionomia.net/dataset/740eba2d-27da-4765-8559-74e357162f7f</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/740eba2d-27da-4765-8559-74e357162f7f">https://gbif.org/dataset/740eba2d-27da-4765-8559-74e357162f7f</a>. Formatted as a Frictionless Data package
Abstract 4765: The role of estrogen receptor signalling in serous ovarian cancer.
No full textAbstract
Epithelial ovarian cancer is a heterogeneous group of diseases with multiple histotypes which can be broadly divided into a dualistic model based on morphological, molecular genetic, and clinical features. The most common and aggressive of all EOC, accounting for 90% of deaths, is High Grade Serous Carcinoma (HGSC). It is characterized by a genetically unstable, rapidly growing phenotype, is diagnosed at advanced stage with poorly defined cancer precursors compared to the more indolent Low Grade Serous Carcinoma (LGSC). Reproductive hormone receptor status (estrogen/ progesterone receptor) may be an important indicator of response to anti-hormonal therapy in ovarian cancer. There have been few reports detailing the expression of ER in HGSC, LGSC and the normal fallopian tube epithelium, the likely cell of origin of both histotypes. We hypothesize that some ER mediated signaling is maintained despite the loss of progesterone receptor in HGSC compared to the LGSC.
Methodology: Snap-frozen tissues (43 HGSC and 18 LGSC) were selected from the UHN Biobank. We used our previously published gene expression profiles to generate a candidate gene list, which was chosen based on the presence of known estrogen responsive elements. They were validated by qPCR and immunohistochemistry on HGSC and LGSC tissue microarrays. Human fallopian tube epithelial cell lines were treated with estradiol at 50nm to determine ‘normal’ ER response. An ER positive cancer cell line (SKOV3) was used to determine the cellular response to candidate genes. IHC was scored using automated image analysis. Statistical analysis was performed using ANOVA and Fisher's Exact Test.
Results: 35/43 (81%) of HGSC were ER+/PR- whilst 9/27 of LGSC were ER+/PR- and 18/27 ER+/PR+. Gene expression analysis of ER+ HGSC and ER- HGSC revealed 881 genes with more than a 2-FC in gene expression including 202 genes with known or putative estrogen responsive elements. They are involved in immune response, locomotion, metanephrous development and cellular adhesion. We compared genes that were differentially expressed between normal fallopian tube cells obtained during pre- or post-ovulation (93 genes). 42 ‘FTE-normal’ genes were differentially expressed between ER- versus ER+ HGSC. We selected 5 genes to validate by qPCR and IHC, based on gene ontology and known associations to cancer pathways.
Conclusions: These results show that HGSC is predominantly an ER+/ PR- cancer (80%) while LGSC is predominantly an ER positive/ PR positive cancer (66%). Our data also indicate that some ER signalling is maintained in the absence of the progesterone receptor and ER+ HGSC are transcriptionally different from ER- HGSC although, there is no distinct clinical benefit between these two groups. ER is still able to transcriptionally activate a subset of known ER target genes and this information should provide further insight into the use of hormone receptors as indicators of anti-hormone therapy in ovarian cancer.
Citation Format: Sophia Hl George, Anca Milea, Ramlogan Sowamber, Danielle Toccalino, Patricia A. Shaw. The role of estrogen receptor signalling in serous ovarian cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4765. doi:10.1158/1538-7445.AM2013-476
Evaluation of the Hiring Methods of Law 4765/2021 : The Written Competition
No full textΗ παρούσα διπλωματική εργασία, περιγράφει τους λόγους που οδήγησαν σταδιακά τη
Δημόσια Διοίκηση, σε νέους τρόπους προσλήψεων Προσωπικού στο Δημόσιο τομέα, με
στόχο την υιοθέτηση ενός αξιοκρατικού και όχι ευνοιοκρατικού συστήματος επιλογής
προσωπικού, που θα ανέτρεπε τις καθιερωμένες πρακτικές των πελατειακών σχέσεων
μέσα από μία αποπολιτικοποιημένη διαδικασία.
Αρχικά, γίνεται μια εισαγωγή στις Ανεξάρτητες Αρχές και διερευνάται ο θεσμικός ρόλος
και οι αρμοδιότητες του ΑΣΕΠ από την ίδρυσή του μέχρι σήμερα.
Στη συνέχεια, αναφέρονται οι μέθοδοι επιλογής προσωπικού στην Ελληνική Δημόσια
Διοίκηση, ξεκινώντας με μια περιληπτική περιγραφή των συστημάτων προσλήψεων στην
Ελλάδα, από το 1951 μέχρι σήμερα. Εκεί, εντοπίζονται τα προβλήματα και οι παθογένειες
του συστήματος, με συνέπεια τις πολυάριθμες τροποποιήσεις των νόμων προς βελτίωση
του συστήματος και καταλήγοντας έτσι, στην αναγκαιότητα μιας αναμόρφωσης του
συστήματος προσλήψεων, με την ψήφιση του νέου Ν. 4765/2021.
Τέλος, αναλύονται και αξιολογούνται οι μέθοδοι προσλήψεων του Ν. 4765/2021, και
ιδιαίτερα του Πανελλήνιου γραπτού διαγωνισμού
Στην παρούσα εργασία, εφαρμόζεται η μεθοδολογία της βιβλιογραφικής επισκόπησης από
πρωτογενείς και δευτερογενείς πηγές, καθώς και της νομοθεσίας.
Στόχος είναι να γίνει αξιολόγηση των συστημάτων πρόσληψης του Ν. 4765/2021 και να
εκτιμηθεί, εάν, η μέθοδος του Πανελλήνιου γραπτού διαγωνισμού, ως ένα ενιαίο σύστημα
προσλήψεων, διατηρεί τις βασικές αρχές, της διαφάνειας, της αξιοκρατίας, της
αντικειμενικότητας και βελτιώνει την ποιότητα και αποτελεσματικότητα του ανθρώπινου
δυναμικού της Ελληνικής Δημόσιας Διοίκησης.This thesis, describes the reasons that gradually led the Public Administration to new
methods of hiring Personnel in the Public sector, with the aim of adopting a meritocratic
and not favoritism personnel selection system, which would overturn the established
practices of customer relations through a depoliticized process.
First an introduction to the Independent Authorities is made and the institutional role and
responsibilities of the ASEP from its establishment until today are explored.
Then, the personnel selection methods in the Greek Public Administration are mentioned,
starting with a summary description of the hiring methods in Greece, from 1951 until
today. There, the problems and pathologies of the system are identified, resulting in
numerous amendments to the laws to improve the system and thus resulting in the
necessity of reforming the recruitment system, with the passing of the new Law
4765/2021.
Finally, the hiring methods of Law 4765/2021, and especially the Panhellenic written
competition, are analyzed and evaluated
In this work, the methodology of the bibliographic review from primary and secondary
sources, as well as legislation, is applied.
The aim is to evaluate the hiring methods of Law 4765/2021 and to assess whether the
method of the Panhellenic written competition, as a single hiring method, maintains the
basic principles of transparency, meritocracy, objectivity and improves quality and
effectiveness of the human resources of the Greek Public Administration
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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