1,730,348 research outputs found
Block Card 4738 Talmadge Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch Style | 4738 Talmadge Road (Toledo, Ohio) | Dwelling | Estero Place (Toledo, Ohio) | Trilby Area (Toledo, Ohio)
Exosome miR-4738-3p-mediated regulation of COL1A2 through the NF-κB and inflammation signaling pathway alleviates osteoarthritis low-grade inflammation symptoms
Get PDFThis study aimed to elucidate the roles of microRNA (miR)-4738-3p and the collagen type I alpha 2 chain (COL1A2) gene in the pathogenesis of osteoarthritis (OA) through bioinformatics analysis and cellular assays. The GSE55235 dataset was analyzed using the weighted gene co-expression network analysis (WGCNA) method to identify gene modules associated with OA. Key overlapping genes were identified from these modules and the GSE55235-differential expressed genes (DEGs). The expression levels of selected genes were determined in C28/I2 cells using the quantitative real-time polymerase chain reaction (qRT-PCR). The interaction between miR-4738-3p and COL1A2 was examined in the context of interleukin 1 beta (IL-1β) induction. Exosome characterization was achieved through transmission electron microscopy (TEM), western blotting (WB), and other analyses. The study also investigated the functional relevance of miR-4738-3p in OA pathology through various molecular and cellular assays. Our findings revealed that the green module exhibited a strong correlation with the OA phenotype in the GSE55235 dataset, with COL1A2 emerging as a hub gene and miR-4738-3p as its key downstream target. IL-1β induction suggested that COL1A2 is involved in inflammation and apoptosis, while miR-4738-3p appeared to play an antagonistic role. The analysis of exosomes underscored the significance of miR-4738-3p in cellular communication, with an enhanced level of exo-miR-4738-3p antagonizing IL-1β-induced inflammation and promoting cell survival. Conversely, a reduction in exo-miR-4738-3p led to increased cell damage. This study established a clear regulatory relationship between miR-4738-3p and COL1A2, with the nuclear factor kappa B (NF-κB) signaling pathway playing a central role in this regulation. The miR-4738-3p significantly influences the OA-associated inflammation, primarily through modulation of COL1A2 and the NF-κB pathway. Therefore, targeting miR-4738-3p offers a potential therapeutic approach for OA, with exosome miR-4738-3p presenting a promising strategy
Ν.4738/2020 (Νέος Πτωχευτικός Κώδικας) – Οδηγία Ε.Ε. 1023/2019
No full textΠεριέχει βιβλιογραφικές παραπομπέςΟ νέος πτωχευτικός νόμος 4738/2020, όπως ενσωματώθηκε στην ελληνική έννομη τάξη με την Οδηγία ΕΕ 1023/2019, και όπως τιτλοφορείται, έχει η «δεύτερη ευκαιρία», νοούμενη ως απαλλαγή του οφειλέτη – φυσικού προσώπου από τα χρέη του, ώστε να μπορεί να υλοποιηθεί το «νέο ξεκίνημα» (fresh start) μετά τη διαδικασία.63 σ
Linked collectors and determiners for: Apoyo a las colecciones biológicas de la Facultad de Ciencias de la UNAM: Fase 1 (Plantas vasculares).
No full textNatural history specimen data linked to collectors and determiners held within, "Apoyo a las colecciones biológicas de la Facultad de Ciencias de la UNAM: Fase 1 (Plantas vasculares)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/f39d15ff-c218-4738-a9e9-6bc8688f8027">https://bionomia.net/dataset/f39d15ff-c218-4738-a9e9-6bc8688f8027</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/f39d15ff-c218-4738-a9e9-6bc8688f8027">https://gbif.org/dataset/f39d15ff-c218-4738-a9e9-6bc8688f8027</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Revision of the bee group Anthophora (Micranthophora) (Hymenoptera: Apidae), with notes on potential conservation concerns and a molecular phylogeny of the genus.
No full textNatural history specimen data linked to collectors and determiners held within, "Revision of the bee group Anthophora (Micranthophora) (Hymenoptera: Apidae), with notes on potential conservation concerns and a molecular phylogeny of the genus". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/555c12a5-9aed-4738-8ac9-22e469bf7687">https://bionomia.net/dataset/555c12a5-9aed-4738-8ac9-22e469bf7687</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/555c12a5-9aed-4738-8ac9-22e469bf7687">https://gbif.org/dataset/555c12a5-9aed-4738-8ac9-22e469bf7687</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Effect of monomeric immunoglobulin G (IgG) on the clearance of soluble aggregates of IgG in man
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4738.pdf (Publisher’s version ) (Open Access
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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