1,724,175 research outputs found
Hesych. κ 4581 L. e uno scolio aristofaneo
No full textLa fonte di Hsch. κ 4581 può essere individuata in Sch. Ar. Av. 1203, che probabilmente conserva materiale esegetico eratostenico
Linked collectors and determiners for: Notes on taxonomy and distribution of some Palaearctic Ancylosis Zeller, 1839 (Lepidoptera: Pyralidae: Phycitinae).
No full textNatural history specimen data linked to collectors and determiners held within, "Notes on taxonomy and distribution of some Palaearctic Ancylosis Zeller, 1839 (Lepidoptera: Pyralidae: Phycitinae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/4aa2e26d-4581-4d6a-ac67-346c45369a48">https://bionomia.net/dataset/4aa2e26d-4581-4d6a-ac67-346c45369a48</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/4aa2e26d-4581-4d6a-ac67-346c45369a48">https://gbif.org/dataset/4aa2e26d-4581-4d6a-ac67-346c45369a48</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Taxonomic revision of the P. chartergoides species-group of the genus Protopolybia Ducke, 1905 (Hymenoptera: Vespidae, Polistinae).
No full textNatural history specimen data linked to collectors and determiners held within, "Taxonomic revision of the P. chartergoides species-group of the genus Protopolybia Ducke, 1905 (Hymenoptera: Vespidae, Polistinae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/aae4f8ee-4581-4c88-91b4-cf8fe9298a28">https://bionomia.net/dataset/aae4f8ee-4581-4c88-91b4-cf8fe9298a28</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/aae4f8ee-4581-4c88-91b4-cf8fe9298a28">https://gbif.org/dataset/aae4f8ee-4581-4c88-91b4-cf8fe9298a28</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: A new species of the genus Diogenes Dana, 1851 (Crustacea: Decapoda: Anomura: Diogenidae) from Gujarat, northwestern India.
No full textNatural history specimen data linked to collectors and determiners held within, "A new species of the genus Diogenes Dana, 1851 (Crustacea: Decapoda: Anomura: Diogenidae) from Gujarat, northwestern India". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/0cbb9fda-c578-4581-b9c6-0bcd417ebc3d">https://bionomia.net/dataset/0cbb9fda-c578-4581-b9c6-0bcd417ebc3d</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/0cbb9fda-c578-4581-b9c6-0bcd417ebc3d">https://gbif.org/dataset/0cbb9fda-c578-4581-b9c6-0bcd417ebc3d</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Neostasina gen. nov., a new genus of huntsman spiders from the Neotropical region (Araneae, Sparassidae, Sparianthinae).
No full textNatural history specimen data linked to collectors and determiners held within, "Neostasina gen. nov., a new genus of huntsman spiders from the Neotropical region (Araneae, Sparassidae, Sparianthinae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/db33d89d-f25a-4581-96e1-8a87edc6fe0f">https://bionomia.net/dataset/db33d89d-f25a-4581-96e1-8a87edc6fe0f</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/db33d89d-f25a-4581-96e1-8a87edc6fe0f">https://gbif.org/dataset/db33d89d-f25a-4581-96e1-8a87edc6fe0f</a>. Formatted as a Frictionless Data package
Abstract 4581: A novel virus-drug combination to enhance oncolysis in renal cell carcinoma
No full textAbstract Background: Oncolytic viruses (OVs) represent a promising option for treatment of advanced cancers. There are few studies assessing the effects of oncolytic viruses in renal cell carcinoma. Oncolytic measles virus (MV) is a novel viral platform that previously been shown to induce cell fusion and cytotoxicity in a CD46-dependent manner. The goals of our study are to identify a pharmacological agent that used in combination with oncolytic MV will enhance the virus cytotoxic effects in renal cell carcinoma (RCC) models. Results: To achieve this goal, we performed in vitro assays combining the Edmonston strain of Measles virus expressing eGFP (MV-GFP), whose oncolytic activity in vitro and in vivo has been demonstrated, with several targeted novel agents that include a new generation multikinase inhibitor used in the treatment of RCC, bromodomain inhibitors associated with epigenetic regulation and Triptolide (T) which has been reported as an apoptosis, ER stress, and oxidative stress inducer and inhibitor of angiogenesis. 786-0 (VHL-mut), A498 (VHL mutant), Caki-1 (VHL-wt) and ACHN (VHL-wt) RCC cells were seeded and treated with oncolytic MV, and the compounds including T. Cell viability as well as cytotoxicity were quantitated at 24, 48 and 72h. Evaluation of single agent activity showed that MV and T were associated with the most significant growth inhibitory or cytotoxic effects. Among the MV-drug combinations, we found that low dose of T was associated with the most significant augmentation of MV oncolysis in RCC cell lines, demonstrated by both viability cell count and by real time monitoring of cell growth by xCELLigence based assays. We found that the treatment sequence (virus infection followed by T treatment) was an important determinant of the combined tumor cytotoxic effects. In addition to enhanced tumor cytotoxicity, we also observed that T enhanced viral replication in RCC, which may explain in part the mechanisms of drug synergy. Finally, we investigated the molecular changes associated with RCC oncolysis by MV alone and in combination with T with RPPA (Reverse Phase Protein Array) and western blot validation and enhanced viral oncolysis induced by the MV-T combination was found to be associated with increased apoptosis (PARP cleavage), ER stress induction (pEIF2a, CHOP) and down regulation of survival and proliferation pathways (pAKT) 36h post-treatment. Conclusion: We identified a novel strategy to enhance RCC viral oncolysis by MV-T combination, by mechanisms that include enhanced viral replication with subsequent increase in the cell death, ER stress pathways and down regulation of pAKT. Current efforts are focused on identifying in vivo antitumor effects and mechanisms of this combination that will open new horizons for the development of rational combinations to improve oncolytic measles virotherapies in RCC, which could lead to long term responses/cures in this disease. Citation Format: Valery A. Chavez, Natasha Khatwani, Ashok Saluja, Jaime Merchan. A novel virus-drug combination to enhance oncolysis in renal cell carcinoma [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 4581
Linked collectors and determiners for: A new species of the genus Diogenes Dana, 1851 (Crustacea: Decapoda: Anomura: Diogenidae) from Gujarat, northwestern India.
No full textNatural history specimen data linked to collectors and determiners held within, "A new species of the genus Diogenes Dana, 1851 (Crustacea: Decapoda: Anomura: Diogenidae) from Gujarat, northwestern India". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/0cbb9fda-c578-4581-b9c6-0bcd417ebc3d">https://bionomia.net/dataset/0cbb9fda-c578-4581-b9c6-0bcd417ebc3d</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/0cbb9fda-c578-4581-b9c6-0bcd417ebc3d">https://gbif.org/dataset/0cbb9fda-c578-4581-b9c6-0bcd417ebc3d</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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