1,724,231 research outputs found
A 4454-Point Scrabble Game
Get PDFIn the following solitaire Scrabble game all 100 tiles have been used to amass a score of 4454 points. Letters with an asterisk represent blank tiles
On the binary nature of the γ-ray sources AGL J2241+4454 (= MWC 656) and HESS J0632+057 (= MWC 148)
No full textWe present optical spectroscopy of MWC 656 and MWC 148, the proposed optical counterparts of the gamma-ray sources AGL J2241+4454 and HESS J0632+0 57, respectively. The main parameters of the Halpha emission line (EW, FWHM and centroid velocity) in these stars are modulated on the proposed orbital periods of 60.37 and 321 days, respectively. These modulations are likely produced by the resonant interaction of the Be discs with compact stars in eccentric orbits. We also present radial velocity curves of the optical stars folded on the above periods and obtain the first orbital elements of the two gamma-ray sources thus confirming their binary nature. Our orbital solution support eccentricities e~0.4 and 0.83+-0.08 for MWC 656 and MWC 148, respectively. Further, our orbital elements imply that the X-ray outbursts in HESS J0632+057/MWC 148 are delayed ~0.3 orbital phases after periastron passage, similarly to the case of LS I +61 303. In addition, the optical photometric light curve maxima in AGL J2241+4454/MWC 656 occur ~0.25 phases passed periastron, similar to what is seen in LS I +61 303. We also find that the orbital eccentricity is correlated with orbital period for the known gamma-ray binaries. This is explained by the fact that small stellar separations are required for the efficient triggering of VHE radiation. Another correlation between the EW of Halpha and orbital period is also observed, similarly to the case of Be/X-ray binaries. These correlations are useful to provide estimates of the key orbital parameters Porb and e from the Halpha line in future Be gamma-ray binary candidates
Identifikasi peran hsa-miR-4454 pada penuaan kulit: Studi klinis dan bioinformatik
No full textPendahuluan: Penuaan kulit adalah proses kompleks yang melibatkan faktor intrinsik dan ekstrinsik. Berbagai parameter untuk mengevaluasi karakteristik kulit telah diusulkan. Namun, biomarker yang akurat untuk penuaan kulit dan hubungan mekanisme molekuler penuaan kulit masih sangat terbatas. Penelitian ini bertujuan untuk memvalidasi peran mikroRNA (miRNA) dalam regulasi epigenetik penuaan kulit sebagai kandidat biomarker dan target terapi.
Metode: Profil ekspresi miRNA kakek dan cucu dari 2 famili Jawa dibandingkan untuk memilih kandidat miRNA yang memiliki perbedaan ekspresi pada jaringan kulit. Selanjutnya, miRNA yang mengalami perubahan ekspresi tersebut dianalisis fungsi dan perannya pada tingkat molekuler dengan pendekatan bioinformatika.
Hasil: Hasil profiling menunjukkan miR-4454 yang konsisten mengalami peningkatan ekspresi pada kedua famili yaitu sebesar 3,318 pada famili I dan 9,315 pada famili II. Berdasarkan data dari GeneCards, miR-4454 memiliki ekspresi yang cukup tinggi pada kulit dan diekspresikan pada seluruh komponen sel. Analisis data dari GWAS mengindikasikan bahwa miR-4454 terlibat dalam pengaturan panjang telomer. Analisis gen target dengan menggunakan TargetScanHuman, miRTarBase, miRTargetLink dilanjutkan dengan pengayaan ontologi gen dan jalur molekuler dengan platform EnrichR menunjukkan miR-4454 berperan dalam regulasi produksi IL-12, respons terhadap radiasi, autofagi, metabolisme, FoxO signaling pathway, dan cellular senescence. Gen ataxia telangiectasia mutated (ATM) dan mitogen-activated protein kinase 14 (MAPK14) diduga berperan penting pada regulasi penuaan kulit akibat miR-4454 karena keterlibatannya pada cellular senescence.
Simpulan: Pada penuaan kulit, ekspresi miR-4454 yang tinggi berpotensi digunakan sebagai kandidat biomarker dan dasar pengembangan target terapi. Gen ATM dan MAPK14 merupakan dua kandidat target miR-4454. Pendahuluan: Penuaan kulit adalah proses kompleks yang melibatkan faktor intrinsik dan ekstrinsik. Berbagai parameter untuk mengevaluasi karakteristik kulit telah diusulkan. Namun, biomarker yang akurat untuk penuaan kulit dan hubungan antara biomarker dengan mekanisme molekuler penuaan kulit masih sangat terbatas. Penelitian ini bertujuan untuk validasi peran mikroRNA (miRNA) dalam regulasi epigenetik penuaan kulit sebagai kandidat biomarker dan target terapi.
Metode: Profil ekspresi miRNA kakek dan cucu dari 2 keluarga Jawa dibandingkan untuk memilih kandidat miRNA yang memiliki perbedaan ekspresi pada jaringan kulit. Selanjutnya, miRNA yang mengalami perubahan ekspresi tersebut dianalisis fungsi dan peran nya pada tingkat molekuler dengan pendekatan bioinformatika.
Hasil: Hasil profiling menunjukkan miR-4454 yang konsisten mengalami peningkatan ekspresi pada kedua Famili yaitu sebesar 3,318 pada Famili I dan 9,315 pada Famili II. Berdasarkan data dari GeneCards, miR-4454 memiliki ekspresi yang cukup tinggi pada kulit dan diekspresikan pada seluruh komponen sel. Analisis data dari GWAS mengindikasikan bahwa miR-4454 terlibat dalam pengaturan panjang telomer. Analisis gen target dengan menggunakan TargetScanHuman, miRTarBase, miRTargetLink dilanjutkan dengan pengayaan ontologi gen dan jalur molekuler dengan platform EnrichR menunjukkan miR-4454 berperan dalam regulasi produksi IL-12, respon terhadap radiasi, autofagi, metabolisme, FoxO signaling pathway, dan cellular senescence. Gen ataxia telangiectasia mutated (ATM) dan mitogen-activated protein kinase 14 (MAPK14) diduga berperan penting pada regulasi penuaan kulit akibat miR-4454 karena keterlibatannya pada cellular senescence.
Simpulan: Pada penuaan kulit, ekspresi miR-4454 yang tinggi berpotensi digunakan sebagai kandidat biomarker dan dasar pengembangan target terapi. Gen ATM dan MAPK14 merupakan dua kandidat target miR-4454.
 
Supplementary Figures 1-5 and Tables 1-3 from Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation
No full textS1. The top pathways regulated by the 26 common microRNAs and miR-4454 expression in a panel of cells. S2. Validation of miR-4454 overexpression and inhibition in OC cells. S3. Functional effects of stable overexpression of miR-4454 in OVCAR8. S4. Genes and pathways regulated by miR-4454. S5. miR-4454 target validation. Supplementary Table 1 : Clinical characteristics of the 42 epithelial ovarian cancer patients. Supplementary Table 2: List of microRNAs downregulated in both OC patient primary tumor vs. matched metastasis and in Kuramochi/OVCAR4/OVCAR8 cells on 3D omental culture vs. control. Supplementary Table 3: Subset of miR-4454 targets with cancer relevant functions based on a literature search.</p
Linked collectors and determiners for: A new species of Daploeuros Watts (Coleoptera: Scirtidae).
No full textNatural history specimen data linked to collectors and determiners held within, "A new species of Daploeuros Watts (Coleoptera: Scirtidae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/b59f0ee3-dc9d-4454-823f-cf8d1b46356f">https://bionomia.net/dataset/b59f0ee3-dc9d-4454-823f-cf8d1b46356f</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/b59f0ee3-dc9d-4454-823f-cf8d1b46356f">https://gbif.org/dataset/b59f0ee3-dc9d-4454-823f-cf8d1b46356f</a>. Formatted as a Frictionless Data package
Southern Pacific (SP) 4333 & 4454 on "Golden State"
No full textA photograph postcard showing the Southern Pacific (SP) 4333, 4-8-2, and 4454, 4-8-4, on passenger train No. 4, "Golden State", eastbound climbing Beaumont Hill at Nicklin, CA
Erratum: 'Percolation model for electrical breakdown in insulating polymers' (vol 85, pg 4454, 2004)
No full textErratum: 'Percolation model for electrical breakdown in insulating polymers' (vol 85, pg 4454, 2004
The Gamma-Ray Source AGL J2241+4454 as the Possible Counterpart of MWC 656
Get PDFAGILE discovered the transient source AGL J2241+4454 in 2010, which triggered the study of the associated field allowing for the discovery of the first Be/black hole binary system: MWC 656. This binary was suggested to be the counterpart of AGL J2241+4454, but this association is still not robust. In this work we explore the archival AGILE and Fermi/Large Area Telescope (LAT) data to find more transient events compatible with AGL J2241+4454 and address the possibility to link them to the accretion/ejection processes of MWC 656. We found a total of nine other transient events with AGILE compatible with the position of AGL J2241+4454, besides the 2010 one. We folded these events with the period of the binary system and we could not associate the gamma-ray activity with any particular orbital phase. By stacking the 10 transient events we obtained a spectrum that extends between 100 MeV and 1 GeV, and we fitted it with a power law with a photon index Γ = 2.3 +/- 0.2. We searched the Fermi/LAT data in order to complement the gamma-ray information provided by AGILE but no significant results arose. To investigate this apparent contradiction between these telescopes, we studied the exposure of the field of AGL J2241+4454 in both instruments, and found significant differences. In particular, AGILE exposed, for a longer time and at a lower off-axis angular distance, the field of AGL J2241+4454. This fact, together with the energy-dependent sensitivity of both instruments, and the soft spectrum found in the stacking analysis, might explain why AGILE observed the transient events not seen by Fermi/LAT
- …
