1,725,444 research outputs found
Astronomische Nachrichten, Vol. 183, nos 4369-4392
No full textF. G. Astronomische Nachrichten, Vol. 183, nos 4369-4392. In: Bulletin astronomique, tome 29, 1912. pp. 499-519
Block Card 4369 River Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 4369 River Road (Toledo, Ohio) | Dwelling | Arden Place Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Linked collectors and determiners for: Two new species of the bee-mimicking genus Mallophora (Diptera, Asilidae) from Colombia.
No full textNatural history specimen data linked to collectors and determiners held within, "Two new species of the bee-mimicking genus Mallophora (Diptera, Asilidae) from Colombia". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/f4b7e77a-07f1-4369-8c6a-73456c97a772">https://bionomia.net/dataset/f4b7e77a-07f1-4369-8c6a-73456c97a772</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/f4b7e77a-07f1-4369-8c6a-73456c97a772">https://gbif.org/dataset/f4b7e77a-07f1-4369-8c6a-73456c97a772</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Abstract 4369: Eradication of chemotherapy-resistant CD44+ human ovarian cancer stem cells in C.B-17/SCID mice by intraperitoneal administration of Clostridium Perfringens Enterotoxin (CPE)
No full textAbstract
Emerging evidence has suggested that the capability to sustain tumor formation, growth and resistance to chemotherapy in ovarian as well as other human malignancies, exclusively resides in a small proportion of tumor cells termed cancer stem cells (CSC). If this hypothesis is correct, different therapeutic approaches need to be considered for the elimination of the cancer stem cell population. During the characterization of CD44+ ovarian CSC we found a high expression of the genes encoding for claudin-4. Because this tight junction protein is the natural high affinity receptor for the cytotoxic effect of Clostridium Perfringens Enterotoxin (CPE), we have extensively investigated the sensitivity of ovarian CSC to CPE treatment in vitro and in vivo. We report that CD44+ ovarian CSC expressed claudin-4 gene at significantly higher levels when compared to matched autologous CD44- ovarian cancer cells and, regardless of their higher resistance to chemotherapeutic agents, died within 1 hr to the exposure to 1.0 μg/mL of CPE in vitro. Importantly, multiple intraperitoneal (i.p.) administration of sublethal doses of CPE in SCID mouse harboring established xenografts of chemotherapy resistant CD44+ ovarian CSC had a significant inhibitory effect on tumor progression leading to the cure and/or long term survival of all treated animals (p = 0.001). CPE may represent an unconventional, potentially highly effective strategy to eradicate chemotherapy resistant CSC.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4369. doi:10.1158/1538-7445.AM2011-436
Linked collectors and determiners for: Ceraphron krogmanni (Hymenoptera: Ceraphronidae), a new species from Lower Saxony with unusual male genitalia.
No full textNatural history specimen data linked to collectors and determiners held within, "Ceraphron krogmanni (Hymenoptera: Ceraphronidae), a new species from Lower Saxony with unusual male genitalia". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/d6c2d094-4369-429f-833c-9d3cb0261023">https://bionomia.net/dataset/d6c2d094-4369-429f-833c-9d3cb0261023</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/d6c2d094-4369-429f-833c-9d3cb0261023">https://gbif.org/dataset/d6c2d094-4369-429f-833c-9d3cb0261023</a>. Formatted as a Frictionless Data package
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Role of 4-Thiazolidinone–Pyrazoline/Indoline Hybrids Les-4369 and Les-3467 in BJ and A549 Cell Lines
Full text linkCancer is one of the most important problems of modern societies. Recently, studies have reported the anticancer properties of rosiglitazone related to its ability to bind peroxisome proliferator
receptor γ (PPARγ), which has various effects on cancer and can inhibit cell proliferation. In this study, we investigated the effect of new 4-thiazolidinone (4-TZD) hybrids Les-4369 and Les-3467 and
their effect on reactive oxygen species (ROS) production, metabolic activity, lactate dehydrogenase (LDH) release, caspase-3 activity, and gene and protein expression in human foreskin fibroblast (BJ) cells and lung adenocarcinoma (A549) cells. The ROS production and caspase-3 activity were mainly increased in the micromolar concentrations of the studied compounds in both cell lines. Les-3467 and Les-4369 increased the mRNA expression of PPARG, P53 (tumor protein P53), and ATM
(ATM serine/threonine kinase) in the BJ cells, while the mRNA expression of these genes (except PPARG) was mainly decreased in the A549 cells treated with both of the tested compounds. Our results indicate a decrease in the protein expression of AhR, PPARγ, and PARP-1 in the BJ cells exposed to 1 µM Les-3467 and Les-4369. In the A549 cells, the protein expression of AhR, PPARγ, and PARP-1 increased in the treatment with 1 µM Les-3467 and Les-4369. We have also shown the PPARγ modulatory properties of Les-3467 and Les-4369. However, both compounds prove weak anticancer properties evidenced by their action at high concentrations and non-selective effects against BJ and A549 cells
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