1,724,691 research outputs found
Pre-registration - PSYC 4240 Final Project
No full textThis Pre-registration consist of information regarding my study for PSYC 4240 final project
Block Card 4240 Birchtree Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 4240 Birchtree Drive (Toledo, Ohio) | Hipped roof | Nopper Garden Estates Plat 1 | Franklin Park Area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | Ranch house
Block Card 4240 Willys Parkway
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling (Toledo, Ohio) | side gabled folk house | Tudor Revival | Homeville Subdivision (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 4240 Willys Parkway (Toledo, Ohio
Block Card 4240 Miramar Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 4240 Miramar Drive (Toledo, Ohio) | Heatherwoods (Toledo, Ohio) | South Toledo Area (Toledo, Ohio) | Ranch houses | Dwellin
Block Card 4240 Deepwood Lane
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Greek Revival Style | 4240 Deepwood Avenue (Toledo, Ohio) | Dwelling | Amended Plat of Copland Heights (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Abstract 4240: Determination of normative patterns of gene expression levels and breast cancer risk biomarkers in human breast milk
No full textAbstract
Parity and breastfeeding influence a woman’s risk of developing breast cancer. Understanding the underlying molecular changes in the breast will facilitate identification of additional factors during pregnancy and postpartum that modify breast cancer risk. Most prior studies in humans on this topic, however, have been cross-sectional studies comparing breast tissue samples from nulliparous versus post-pregnant women, and are limited in their ability to characterize longitudinal changes and within-person variations. Breast milk contains cells of the mature gland, and may have a potential as a noninvasive source for studying molecular characteristics of the pregnancy-associated changes in the breast and their impact on breast cancer risk. The objectives of this study were to (1) determine normative patterns of gene expression levels in longitudinally collected breast milk samples and (2) correlate gene expression data in relation to self-reported measures of psychosocial stress during pregnancy and postpartum period. Our preliminary results showed that the post-pregnancy gene expression levels in breast milk samples can be measured reproducibly over a short period of time. Whole-genome transcriptome analysis revealed that expression levels of the post-pregnancy genes are different in early (less than 3 month postpartum) and late lactation period (more than 6 month postpartum). Moreover cytokine expression profiling correlated expression of inflammatory cytokines with early versus late postpartum period. The unique contribution of this study is to capture longitudinal gene expression data from breast milk samples collected over the course of lactation, hence providing a valuable basis for future studies to identify differential dynamics associated with breast cancer susceptibility.
Note: This abstract was not presented at the meeting.
Citation Format: Maria Ouzounova, Georgina Lewis, Raziye Piranlioglu, Tiana Curry-McCoy, Wonsuk Yoo, Nita Maihle, Sangmi Kim, Hasan Korkaya. Determination of normative patterns of gene expression levels and breast cancer risk biomarkers in human breast milk [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4240. doi:10.1158/1538-7445.AM2017-4240</jats:p
Block Card 4240 Glendale Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 4240 Glendale Avenue (Toledo, Ohio) | Dwelling | South Toledo Area (Toledo, Ohio) | Bungalow Style | Side gabled | Craftsman Styl
Neurovascular Coupling Remains Intact During Incremental Ascent to High Altitude (4240 m) in Acclimatized Healthy Volunteers
Get PDFNeurovascular coupling (NVC) is the temporal link between neuronal metabolic activity and regional cerebral blood flow (CBF), supporting adequate delivery of nutrients. Exposure to high altitude (HA) imposes several stressors, including hypoxia and hypocapnia, which modulate cerebrovascular tone in an antagonistic fashion. Whether these contrasting stressors and subsequent adaptations affect NVC during incremental ascent to HA is unclear. The aim of this study was to assess whether incremental ascent to HA influences the NVC response. Given that CBF is sensitive to changes in arterial blood gasses, in particular PaCO2, we hypothesized that the vasoconstrictive effect of hypocapnia during ascent would decrease the NVC response. 10 healthy study participants (21.7 ± 1.3 years, 23.57 ± 2.00 kg/m2, mean ± SD) were recruited as part of a research expedition to HA in the Nepal Himalaya. Resting posterior cerebral artery velocity (PCAv), arterial blood gasses (PaO2, SaO2, PaCO2, [HCO3-], base excess and arterial blood pH) and NVC response of the PCA were measured at four pre-determined locations: Calgary/Kathmandu (1045/1400 m, control), Namche (3440 m), Deboche (3820 m) and Pheriche (4240 m). PCAv was measured using transcranial Doppler ultrasound. Arterial blood draws were taken from the radial artery and analyzed using a portable blood gas/electrolyte analyzer. NVC was determined in response to visual stimulation (VS; Strobe light; 6 Hz; 30 s on/off × 3 trials). The NVC response was averaged across three VS trials at each location. PaO2, SaO2, and PaCO2 were each significantly decreased at 3440, 3820, and 4240 m. No significant differences were found for pH at HA (P > 0.05) due to significant reductions in [HCO3-] (P 0.05). NVC remains remarkably intact during incremental ascent to HA in healthy acclimatized individuals. Despite the array of superimposed stressors associated with ascent to HA, CBF and NVC regulation may be preserved coincident with arterial pH maintenance during acclimatization.Library OA FundFinancial support for this work was provided by (a) Natural Sciences and Engineering Research Council of Canada (NSERC) Undergraduate Student Research Assistantship (CM and JP), (b) Alberta Innovates Health Solution Summer studentship (CN), (c) Government of Alberta Student Temporary Employment Program (SZ), and an NSERC Discovery grant (TAD; RGPIN-2016-04915). JL was supported by the Department of Physiology, University College Cork, Ireland
Linked collectors and determiners for: Duke University Herbarium Fungal Collection.
No full textNatural history specimen data linked to collectors and determiners held within, "Duke University Herbarium Fungal Collection". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/6cd25714-849f-4240-a762-ef33aa2e5db5">https://bionomia.net/dataset/6cd25714-849f-4240-a762-ef33aa2e5db5</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/6cd25714-849f-4240-a762-ef33aa2e5db5">https://gbif.org/dataset/6cd25714-849f-4240-a762-ef33aa2e5db5</a>. Formatted as a Frictionless Data package
Lei n. 4240, 09 nov. 1962, GO.
No full textLegislação – Caixa de Leis e Decretos – Goiás - 1962. Um exemplar deste encontra-se disponível no Arquivo Histórico Estadual – AGEPEL – Goiânia, GO.Lei 4240, de 09 de novembro de 1962, com 192 artigos. Documento com 44 páginas. Câmara do Ensino Primário organiza sistema estadual de ensino e dá outras providências
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