1,724,311 research outputs found
Abstract 3992: Immune regulation of disseminated tumor cell clearance versus metastatic growth
No full textAbstract
Metastatic disease is the end stage of extremely inefficient processes that entail overcoming multiple barriers including anti-tumor immunity. Although evidences from preclinical and clinical settings suggest that dissemination of malignant cells is an early process, majority of disseminated cells either eliminated or remain dormant in distant organs, while very few cells eventually develop successful metastasis. Therefore, it is widely accepted that dynamic and reversible tumor cell plasticity is required for metastasis, however, in vivo steps and molecular mechanisms are poorly elucidated.
We provide evidence that monocytic and granulocytic subsets of myeloid derived suppressor cells (m-MDS, g-MDSC) infiltrated in primary 4T1 tumor and distant organs with different time kinetics regulate spatiotemporal tumor plasticity. Using co-culture experiments and syngeneic mouse models of murine 4T1 (metastatic) tumor, we demonstrated that tumor infiltrated m-MDSCs facilitate tumor cell dissemination from the primary site by inducing the EMT/CSC phenotype. In contrast, g-MDSCs infiltrated in the lungs support metastatic growth by reverting the EMT/CSC phenotype and thus promoting tumor cell proliferation. In contrast, less invasive EMT6 tumors fail to induce efficient pulmonary infiltration of g-MDSCs and results in clearance of disseminated tumor cells in the lungs. Gene expression analyses of tumors and MDCS subsets in primary tumor site and distant organs at different time points reveal mechanistic temporal regulation of in vivo tumor plasticity by m-MDSC and g-MDSC subsets in 4T1 tumor-bearing mice. However, the lung microenvironment of EMT6 tumor-bearing mice display a gene expression signature of anti-tumor immunity which predict better survival in breast cancer patients. In our functional studies, we demonstrate that EMT6 tumor-bearing animals efficiently eliminate disseminated tumor cells in the lungs. Furthermore, g-MDSCs isolated from 4T1-tumor bearing animals significantly enhance metastatic growth of already disseminated tumor cells.
Consistent with the “seed and soil” hypothesis, our studies provide a molecular mechanism by which the immune system regulate spatiotemporal tumor plasticity and generation of permissive or anti-tumorigenic microenvironment in distant organs determining the fate of disseminated tumor cells.
Citation Format: Hasan Korkaya, Eunmi Lee, Raziye Piranioglu, Maria Ouzounova, Abdeljabar El-Andaloussi, Iskander Asm, Ahmet K. Korkaya, Gang Zhou, Ali Arbab, Paulo Rodriguez. Immune regulation of disseminated tumor cell clearance versus metastatic growth [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3992. doi:10.1158/1538-7445.AM2017-3992</jats:p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dark and luminous matter in the NGC 3992 group of galaxies - I. The large barred spiral NGC 3992
No full textDetailed neutral hydrogen observations have been obtained of the large barred spiral galaxy NGC 3992 and its three small companion galaxies, UGC 6923, UGC 6940, and UGC 6969. For the main galaxy, the Hi distribution is regular with a low level radial extension outside the stellar disc. However, at exactly the region of the bar, there is a pronounced central Hi hole in the gas distribution. Likely gas has been transported inwards by the bar and because of the emptyness of the hole no large accretion events can have happened in recent galactic times. The gas kinematics is very regular and it is demonstrated that the influence of the bar potential on the velocity field is negligible. A precise and extended rotation curve has been derived showing some distinct features which can be explained by the non-exponential radial light distribution of NGC 3992. The decomposition of the rotation curve gives a slight preference for a sub maximal disc, though a range of disc contributions, up to a maximum disc situation fits nearly equally well. For such a maximum disc contribution, which might be expected in order to generate and maintain the bar, the required mass-to-light ratio is large but not exceptional
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Fig.ç1.S coliorhapis lindbergi (D'yakonov in D'yakonov et al., 1958) comb. nov. A, Living specimen (the specimen was destroyed for preliminary ossicle observation afler the photograph was taken); B, morphology of dissected anterior part of body, lateral view, ZIHU 3992; C, tentacle digits, ZIHU 3992; D, madreporite, ZIHU 3992; E, ciliated funnel, ZIHU 3992; F, tentacle ossicle (lost afler observation); G, radial part of calcareous ring, ZIHU 3993. in Redescription of Scoliorhapis lindbergi comb. nov. (Echinodermata: Holothuroidea: Apodida: Chiridotidae), with Special Reference to the Ultrastructure of Sigmoid Bodies
No full textFig.ç1.S coliorhapis lindbergi (D'yakonov in D'yakonov et al., 1958) comb. nov. A, Living specimen (the specimen was destroyed for preliminary ossicle observation afler the photograph was taken); B, morphology of dissected anterior part of body, lateral view, ZIHU 3992; C, tentacle digits, ZIHU 3992; D, madreporite, ZIHU 3992; E, ciliated funnel, ZIHU 3992; F, tentacle ossicle (lost afler observation); G, radial part of calcareous ring, ZIHU 3993.Published as part of Inoue, Junko & Kajihara, Hiroshi, 2012, Redescription of Scoliorhapis lindbergi comb. nov. (Echinodermata: Holothuroidea: Apodida: Chiridotidae), with Special Reference to the Ultrastructure of Sigmoid Bodies, pp. 15-20 in Species Diversity 17 (1) on page 16, DOI: 10.12782/sd.17.1.015, http://zenodo.org/record/464914
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
3992. Thomas Otterbourne, Chronica regum Angliae, éditée par Th. Hearne, Oxford, 1732
No full text3992. Thomas Otterbourne, Chronica regum Angliae, éditée par Th. Hearne, Oxford, 1732. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). IV. Les Valois, 1328-1461. Paris : A. Picard et fils, 1904. p. 210
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