1,725,046 research outputs found
St. Louis & San Francisco (SLSF) "Frisco" 3736
No full textA photograph print showing the St. Louis and San Francisco (SLSF) "Frisco" 3736, 0-6-0, Joplin, MO
Rotation period determination and lightcurve analysis of Asteroid 3736 Rokoske
Full text linkObservations of the main-belt 3736 Rokoske were conducted over 8 nights between 2022 March 25 and 2022 April 23. Images were collected using three telescopes in the USA, Malta and Italy. 3736 Rokoske has a diameter of 19.5km and an absolute magnitude of 11.15. The phase lightcurve resulted in a rotation period of 17.411+-0.004h and 0.10+-0.02 mag amplitude.peer-reviewe
Churches - African American (SC 3736)
Full text linkFinding aid only for Manuscripts Small Collection 3736. Racist parody of announcements purporting to be from an African American church, written in dialect and describing activities for Easter and other planned meetings. The typewritten text likely dates from the early 20th century and was found in the textbook of a Bowling Green, Kentucky student
Ground-Based Follow-up Observations of TOI 3736 a
Full text link“Ground-based follow-up observations of exoplanet candidates observed by the TESS mission are crucial to ruling out false positives and confirming exoplanet properties. In this paper, we analyze and interpret observations made by the George Mason University Observatory 0.8m telescope of TESS TOI 3736 a. An argument for the exoplanet status of TOI 3736 a is presented alongside several lines of evidence, including the observed transit depth, duration, and periodicity, which are consistent with the presence of a large, hot-jupiter-like planet in close orbit around its host star. In addition, we highlight differences and similarities between the target and similar exoplanets. To further verify the planetary status of TOI 3736 a, we outline potential future work, including high-resolution spectroscopy.
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Abstract 3736: IL6 feedback loop regulates breast cancer stem cells which mediate trastuzumab resistance.
No full textInternational audienceAbstract The development of HER2 targeting agents such as trastuzumab and lapatinib represents one of the greatest achievements in clinical oncology demonstrating the effectiveness of molecularly targeted therapeutics (2). Despite the clinical benefits of trastuzumab in improving progression free and overall survival, majority of patients demonstrate “intrinsic” resistance or develop “acquired” resistance within one-to-two years. Although inactivation of the PTEN gene has been implicated in the development of resistance to the HER2 targeting antibody trastuzumab, the mechanisms mediating this resistance remain to be investigated. We generated trastuzumab resistant cells by knocking down PTEN expression in HER2 overexpressing breast cancer cell lines and demonstrated that development of trastuzumab resistance in these cells is mediated by activation of an IL6 inflammatory feedback loop leading to expansion of breast cancer stem cell (CSC) population. We and others previously demonstrated that cytokines including IL6 and IL8 regulates breast cancer stem cell self-renewal. Furthermore, elevated serum levels of these cytokines in breast cancer patients strongly correlated with metastatic disease and therapeutic resistance. We therefore hypothesized that activation of IL6 feedback loop may mediate trastuzumab resistance. Utilizing these models, we demonstrated that long term trastuzumab treatment generates highly enriched CSCs which display an EMT phenotype secreting over 100-fold more IL6 than parental cells. Recombinant IL6 or conditioned medium from high-IL6 secreting cells resulted in trastuzumab resistance in parental PTEN wild type cells expanding CSCs with EMT phenotype characterized by the CD44+/CD24- expression and EMT gene signature. An IL6 receptor antibody interrupted this inflammatory feedback loop reducing the cancer stem cell population resulting in decreased tumor growth and metastasis in mouse xenographs. These studies have important clinical implications demonstrating that trastuzumab resistance may be mediated by an IL-6 inflammatory loop and suggest that blocking this loop represents a novel strategy to overcome trastuzumab resistance. . Citation Format: April L. Davis, Hasan Korkaya, Maria Ouzounova, Fayaz Malik, Gwangil Kim, Ahmed A. Quraishi, Suling Liu, Shawn G. Clouthier, Max S. Wicha. IL6 feedback loop regulates breast cancer stem cells which mediate trastuzumab resistance. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3736. doi:10.1158/1538-7445.AM2013-373
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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