1,726,720 research outputs found
MiRNA-3653 Is a Potential Tissue Biomarker for Increased Metastatic Risk in Pancreatic Neuroendocrine Tumours
No full textPancreatic neuroendocrine tumours (PNETs) are relatively uncommon, accounting for 1–2% of all pancreatic neoplasms. Tumour grade (based on the Ki67 proliferative index and mitotic rate) is associated with metastatic risk across large cohorts; however, predicting the behaviour of individual tumours can be difficult. Therefore, any tool which could further stratify metastatic risk may be clinically beneficial. We sought to investigate microRNA (miRNA) expression as a marker of metastatic disease in PNETs. Tumours from 37 patients, comprising 23 with locoregional disease (L) and 14 with distant metastases (DM), underwent miRNA profiling. In total 506 miRNAs were differentially expressed between the L and DM groups, with four miRNAs (miR-3653 upregulated, and miR-4417, miR-574-3p and miR-664b-3p downregulated) showing statistical significance. A database search demonstrated that miRNA-3653 was associated with ATRX abnormalities. Mean survival between the two groups was correlated with mean expression of miRNA-3653; however, this did not reach statistical significance (p = 0.204). Although this is a small study, we conclude that miRNA-3653 upregulation may be associated with an increased risk of metastatic disease in PNETS, perhaps through interaction with ATRX and the alternate lengthening of telomeres pathway.No Full Tex
Block Card 3653 Terrace Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3653 Terrance Drive (Toledo, Ohio) | Ranch houses | Ratterrees Boulevard Terrace | Buckeye Basin | North Toledo (Toledo, Ohio
Block Card 3653 Watson Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3653 Watson Avenue (Toledo, Ohio) | Side gabled | Craftsman Style | Almeda Heights Second Addition (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | Folk House Styl
Block Card 3653 Airport Highway
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Side gabled | Bungalows | Dwelling | South Toledo Area (Toledo, Ohio) | 3653 Airport Highway (Toledo, Ohio
Abnormal expression of miR-3653-3p, Caspase 1, IL-1β in peripheral blood of schizophrenia
No full textAbnormal expression of miR-3653-3p, Caspase 1, IL-1β in peripheral blood of schizophrenia; miR-3653-3p, NLRP3 mRNA, caspase 1 mRNA and IL-1β mRNA in the patient group and healthy control group were all converted by square root
Abnormal expression of miR-3653-3p, Caspase 1, IL-1β in peripheral blood of schizophrenia
No full textAbnormal expression of miR-3653-3p, Caspase 1, IL-1β in peripheral blood of schizophrenia; miR-3653-3p, NLRP3 mRNA, caspase 1 mRNA and IL-1β mRNA in the patient group and healthy control group were all converted by square root
Abnormal expression of miR-3653-3p, Caspase 1, IL-1β in peripheral blood of schizophrenia
No full textAbnormal expression of miR-3653-3p, Caspase 1, IL-1β in peripheral blood of schizophrenia; miR-3653-3p, NLRP3 mRNA, caspase 1 mRNA and IL-1β mRNA in the patient group and healthy control group were all converted by square root.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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