1,720,978 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
New treatment of head and neck cancer by normalization of tumor vasculature
Get PDF頭頸部癌治療において、そのキードラッグであるシスプラチンを内包したミセル化シスプラチン（NC-6004）が開発された。腫瘍組織に選択的に集積し抗腫瘍効果を高める一方で、既存のシスプラチンで問題であった腎機能障害等の有害事象を軽減させる。今回、腫瘍組織の異常血管を退縮・破綻させるのではなく「修復」させることで、薬剤供給路の確保を目指す新しい治療戦略を目標とした。頭頸部癌を移植した担癌マウスにおいて、ミセル化シスプラチン投与群に加えて、ミセル化シスプラチン＋TGF-β阻害剤投与群について検討した。異常血管の多い頭頸部癌に対しTGF-β阻害剤＋ミセル化製剤の頭頸部癌での有用性を認めた。CDDP-incorporating polymeric micellar nanoparticle（NC-6004) have been developed and designed based on the idea that the drug delivery system (DDS) can accumulate in the tumor selectively, with reduced distribution in normal tissues and minimized undesirable side-effect. We aimed to increase the anti-tumor effect through normalization of tumor vasculature. NC-6004 with TGF-β group decreased tumor volume of mice models compared with NC-6004 alone.研究課題/領域番号:25861538, 研究期間(年度):2013-04-01 - 2016-03-31出典：研究課題「腫瘍血管正常化に基づく頭頸部癌新規治療戦略」課題番号25861538
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25861538/25861538seika/）を加工して作成金沢大学附属病院耳鼻咽喉科・頭頸部外科research repor
Research of signaling mechanism in nasopharyngeal cancer
Get PDFEBウイルスの癌蛋白であるLMP1はそのような多くの分子を誘導し上咽頭癌の高転移性に寄与していると考えられているが、その詳しいメカニズムは不明である。近年、核内タンパクであるSATB1がDNAの遺伝子発現に深く関与し、多くの遺伝子発現を制御することが報告された。我々はLMP1とSATB1の上咽頭培養細胞および上咽頭癌組織標本での相互作用を検討した。上咽頭培養細胞においてLMP1を形質導入するとSATB1の誘導が確認された。上咽頭癌組織標本において免疫組織学的検討から、LMP1の発現とSATB1の発現も有意に相関していた。以上から上咽頭癌においてLMP1はSATB1を通して細胞増殖、アポトーシスを制御していることが示唆された.A global regulator of chromatin remodelling and gene expression, special AT-rich-binding protein 1 (SATB1) has been implicated in promotion of growth and metastasis of a number of cancers. Here, we demonstrate that the principal oncogene of Epstein-Barr virus (EBV), latent membrane protein 1 (LMP1) upregulates SATB1 RNA and protein expression in human nasopharyngeal cell lines.We show that SATB1 protein levels are elevated in tissue samplesfrom patients with nasopharyngeal carcinoma (NPC). Taken together, our results suggest that SATB1 functions as a prometastatic effector of LMP1 signalling in EBV-positive NPC.研究課題/領域番号:22791579, 研究期間(年度):2010-2012出典：研究課題「上咽頭癌における細胞接着シグナリング機構の解明」課題番号22791579
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22791579/22791579seika/）を加工して作成金沢大学附属病院research repor
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Bone invasion-targeted chemotherapy with a novel anionic platinum complex (3Pt) for oral squamous cell carcinoma
Get PDFシスプラチンは骨浸潤した腫瘍に対しての制御が悪く、腎機能障害が問題である。こうした背景からシスプラチンにリン酸基をつけ電荷型にした薬剤が開発された（3Pt)。頭頸部癌細胞株を用いて、3Ptとシスプラチンの抗腫瘍,腎機能障害について検討した。頭頸部癌移植モデルマウスを用いた検討では、両者の薬剤は抗腫瘍効果については同等であった。また3ptが腎機能障害が軽減していた。さらに舌癌細胞株を下顎骨に移植したモデルマウスにおいて3Pt投与群がコントロール群やシスプラチン群に比べて、下顎骨の骨破壊の抑制効果が高かった。3Ptは骨浸潤のあるような腫瘍において高い抗腫瘍効果と腎機能障害の軽減が図れる。Cisplatin (CDDP) is an important drug for chemotherapy in patients with head and neck squamous cell carcinoma. To increase its antitumor effect on bone invasion and reduce toxicity problems, anionic Pt complex (3Pt) has been developed. The present study aimed to characterize the basis of the cytotoxicity of the novel platinum complex 3Pt in comparison with that of CDDP . Both 3Pt and CDDP showed equivalent antitumor effects in vivo. Mice injected with CDDP developed renal cell apoptosis; however, those injected with 3Pt were almost free of renal cell injury. In addition to similar in vivo antitumor effects, 3Pt decreased the volume of bone resorption compared to that with CDDP in a bone invasion model using OSC-19. In conclusion, considering the potential advantages in terms of noticeable antitumor activity on bone invasion and reduced nephrotoxicity, 3Pt represents a significant improvement in the development of bone-targeting platinum drug.研究課題/領域番号:16K11227, 研究期間(年度):2016-04-01 - 2020-03-31出典：「ミセル化パクリタキセルによる頭頸部癌次世代治療戦略と薬剤耐性克服への応用」研究成果報告書 課題番号16K11227
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K11227/16K11227seika/）を加工して作成金沢大学附属病院耳鼻咽喉科・頭頸部外科research repor
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
- …
