1,728,680 research outputs found
2981. Suppression des Templiers en Languedoc-Roussillon
No full text2981. Suppression des Templiers en Languedoc-Roussillon. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). III. Les Capétiens, 1180-1328. Paris : A. Picard et fils, 1903. pp. 224-225
Baseline characteristics of total NESDA sample (N = 2981).
No full text<p>*39 missing.</p><p>**35 missing.</p><p>Baseline characteristics of total NESDA sample (N = 2981).</p
Abstract 2981: Regulation of Snail by DDX3 and ATM in response to DNA damage
No full textAbstract
Epithelial-mesenchymal transition (EMT) is the initial step for cancer invasion and metastasis. The hallmark of EMT is the loss of expression of E-cadherin, a cell-cell adhesion protein, allowing cancer cells to gain mobility leaving the site of primary tumor to invade adjacent tissues. Snail, as a transcription repressor, binds to the E-boxes of E-cadherin and then inhibits E-cadherin expression. Thus, Snail is essential to trigger EMT during tumor progression and it has been implicated in the acquisition of invasive growth phenotype of tumors. There is a strong correlation of Snail over-expression with tumor invasion and metastasis. However, how Snail expression is regulated is not fully known. Here we report that Snail is regulated by DDX3, a DEAD box protein family member which contributes to cancer progression. Knock-down of DDX3 by shRNA reduces the basal level of Snail, and this is associated with reduced cell proliferation and migration. Snail protein and mRNA levels are increased in the presence of the HDAC inhibitors sodium butyrate or trichostatin A, and the increases are attenuated in cells with DDX3 knocked down. Treatment of cells with a DNA damaging agent camptothecin also enhances Snail protein levels in a DDX3 dependent manner. Therefore we conclude that DDX3 is required for the basal level and the increase in Snail induced by HDAC inhibitors or camptothecin, indicating that this action of DDX3 may contribute to its promotion of the progression of some cancers. This conclusion is supported by our clinical investigations that analysis of 31 glioblastoma patient samples has revealed a strong correlation between the levels of DDX3 and Snail. Snail is a phosphor-protein, and kinases responsible for phosphorylation include Pak1 and GSK3-β. We also find Pak-1 and GSK-3 independent Snail phosphorylation in response to DNA damage. Further we find that inhibition of the activity of the ATM kinase, a critical element in DNA damage responses, eliminated DNA damage-induced Snail stabilization. Taken together, these observations have highlighted a comprehensive signaling network regulating Snail in response to DNA damage and indicated a critical role of optimal DNA damage responses in tumor invasion and metastasis.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2981.</jats:p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Title XIII. Of Deposit and Sequestration (Art. 2926 - 2981)
Full text linkChap. 1. Of Deposit in General, and of Its Divers Kinds (Art. 2926 - 2927) Chap. 2. Of the Deposit Properly So Called (Art. 2928 - 2963) Chap. 3. Of the Necessary Deposit (Art. 2964 - 2971) Chap. 4. Of Sequestration (Art. 2972 - 2981)https://digitalcommons.law.lsu.edu/la_civilcode_book_iii/1013/thumbnail.jp
Chant des Marais. Nuit et brouillard. SKARBO. D SK 2981, 1998. Diffusion SM
No full textWeber Edith. Chant des Marais. Nuit et brouillard. SKARBO. D SK 2981, 1998. Diffusion SM. In: Cahiers de sociologie économique et culturelle, n°30, 1998. p. 156
Harris, William, 1772-1845 - Relating to (SC 2981)
Full text linkFinding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 2981. Research notes of Mary Leiper Moore, director of the Kentucky Building at Western Kentucky University, related to William Harris, an important early minister in the Cumberland Presbyterian Church
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