1,720,976 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Androgen receptor signaling-controlled microRNA inhibits prostate cancer metastasis
Full text linkCCL2 is inhibited by androgen receptor (AR) signaling in prostate cancer cells. However, androgen-deprivation therapy suppresses AR signaling and subsequently increases CCL2 secretion, resulting increase of migration ability by an autocrine manner. It has been unclear how AR signaling suppresses CCL2 secretion in prostate cancer cells so far. In this study, we clarified AR-regulated microRNA, miR-124-3p.2, inhibited CCL2 gene expression and it may be a novel therapeutic target to prevent prostate cancer progression during androgen-deprivation therapy.CCL2はアンドロゲン受容体(androgen receptor: AR)の活性化状態では抑制されているが、ARが不活化することで自己分泌作用が亢進し、前立腺癌細胞の遊走能を亢進させる。しかし、ARの不活性化でCCL2分泌が亢進する機序は不明であった。本研究ではまず網羅的マイクロRNA(miRNA)解析から複数の候補miRNAを抽出した。その候補の中から、ARシグナルによって発現が亢進し、かつ、CCL2を抑制的に制御しているmiRNAとしてmiR-124-3p.2を同定した。研究課題/領域番号:19K09707, 研究期間(年度):2019-04-01 - 2022-03-31出典：研究課題「ARシグナルの遮断によって活性化する前立腺癌増悪因子の探索と転移指向性の解明」課題番号19K09707
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K09707/19K09707seika/）を加工して作成金沢大学附属病院泌尿器科research repor
Splemectomy for renal cell carcinoma to restore immuno activity
Full text link腫瘍随伴性マクロファージは腎細胞癌細胞との相互作用によりサイトカインシグナルを活性化し、そのシグナルがさらに腫瘍随伴性マクロファージ自体の活性化と骨髄由来サプレッサー細胞の活性化をもたらす可能性が示唆された。進行腎細胞癌患者の血中制御性T細胞数は比較的多かったが、症例毎のばらつきが多いことが明らかになった。骨髄由来サプレッサー細胞も進行癌患者では末梢血中で増加する可能性が示唆された。分子標的薬は骨髄由来サプレッサー細胞の作用を減弱することによる抗腫瘍効果が報告されているが、骨髄由来サプレッサー細胞がすでに分子標的薬で抑制されたあとにIL-2療法を行っても意義が少ないことが示唆された。Tumor-associated macrophages activated cytokine signaling through the interaction with renal cell cancer cells, and then this signaling activated tumor-associated macrophages themselves resulting in myeloid derived suppressor cells. The number of regulatory T cells in blood of advanced kidney caner patients is relatively high and the number of myeloid derived suppressor cells might increase in blood of advanced kidney caner patients,too. As molecular targeting agents can suppress the effect of myeloid derived suppressor cells, it may be better to use IL-2 prior to molecular targeting agents.研究課題/領域番号:15K20076, 研究期間(年度):2015-04-01 - 2017-03-31出典：「免疫寛容離脱を目的とした腎癌治療における脾臓摘除の可能性」研究成果報告書 課題番号15K20076
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K20076/15K20076seika/）を加工して作成金沢大学附属病院泌尿器科research repor
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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