1,734,871 research outputs found
Mandurama photograph collection [2067] [picture] /
No full textAlso available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an8526486-2067
NUORTEN TULEVAISUUSKUVAT 2067 : Näkökulma suomalaisen yhteiskunnan kehittämiseksi
No full textNuorten tulevaisuuskuvat 2067 -tutkimushankkeessa nuorten oma ääni nostetaan kuuluviin ja he osallistuvat keskusteluun siitä, minkälaista Suomea yhdessä tavoittelemme. Tutkimushanke on osa Hämeenlinnan kaupungin koordinoimaa lasten ja nuorten Suomi 100 -juhlavuotta. Hankkeen suunnitteluvaiheessa tutkimuksen aikajänne ulotettiin 50 vuoden päähän Suomen 100-vuotispäivästä eli vuoteen 2067, ja kohderyhmäksi valittiin nuorten ikäryhmä, joka tuolloin nykyisten säädösten perusteella saavuttaa eläkeiän. Tutkimuksessa kartoitetaan ja kuvataan suomalaisten, 16–20 -vuotiaiden nuorten arvomaailman sisältöä sekä tulevaisuuteen kohdistuvia odotuksia ja asenteita selvittämällä, minkälaisia tulevaisuuskuvia nuoret pitävät itselle toivottavimpina ja todennäköisimpinä toimeentuloon, asumiseen ja elämäntapaan liittyen.
Nuorten tulevaisuuskuvat 2067 -hankkeessa tavoitteena on rohkaista nuoria vaihtoehtoisten tulevaisuuksien aktiiviseen pohdintaan ja tuottaa sen perusteella tutkimustietoa siitä, minkälaisia asioita nuoret kokevat merkityksellisinä nyt ja mahdollisesti tulevaisuudessa.ei tietoa saavutettavuudest
2067. Anonymus Vaticanus, ou Chronica Roberti Guiscardi
No full text2067. Anonymus Vaticanus, ou Chronica Roberti Guiscardi. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). II. Époque féodale, les Capétiens jusqu'en 1180. Paris : A. Picard et fils, 1902. pp. 264-265
Benkö Sorsjegye Banko. 2067 Benkö Bank R.T. Budapest Andrassy Ut 60
No full textBENKÖ SORSJEGYE BANKO. 2067 BENKÖ BANK R.T. BUDAPEST ANDRASSY UT 60
Benkö Sorsjegye Banko. 2067 Benkö Bank R.T. Budapest Andrassy Ut 60 ( -
Structures of triazines JPC-2056 and JPC-2067-B.
No full text<p>Structures of triazines JPC-2056 and JPC-2067-B.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Novel Triazine JPC-2067-B Inhibits Toxoplasma gondii In Vitro and In Vivo
No full textBACKGROUND AND METHODOLOGY
Toxoplasma gondii causes substantial morbidity, mortality, and costs for healthcare in the developed and developing world. Current medicines are not well tolerated and cause hypersensitivity reactions. The dihydrotriazine JPC-2067-B (4, 6-diamino-1, 2-dihydro-2, 2-dimethyl-1-(3′(2-chloro-, 4-trifluoromethoxyphenoxy)propyloxy)-1, 3, 5-triazine), which inhibits dihydrofolate reductase (DHFR), is highly effective against Plasmodium falciparum, Plasmodium vivax, and apicomplexans related to T. gondii. JPC-2067-B is the primary metabolite of the orally active biguanide JPC-2056 1-(3′-(2-chloro-4-trifluoromethoxyphenyloxy)propyl oxy)- 5-isopropylbiguanide, which is being advanced to clinical trials for malaria. Efficacy of the prodrug JPC-2056 and the active metabolite JPC-2067-B against T. gondii and T. gondii DHFR as well as toxicity toward mammalian cells were tested.
PRINCIPAL FINDINGS AND CONCLUSIONS
Herein, we found that JPC-2067-B is highly effective against T. gondii. We demonstrate that JPC-2067-B inhibits T. gondii growth in culture (IC50 20 nM), inhibits the purified enzyme (IC50 6.5 nM), is more efficacious than pyrimethamine, and is cidal in vitro. JPC-2067-B administered parenterally and the orally administered pro-drug (JPC-2056) are also effective against T. gondii tachyzoites in vivo. A molecular model of T. gondii DHFR-TS complexed with JPC-2067-B was developed. We found that the three main parasite clonal types and isolates from South and Central America, the United States, Canada, China, and Sri Lanka have the same amino acid sequences preserving key binding sites for the triazine.
SIGNIFICANCE
JPC-2056/JPC-2067-B have potential to be more effective and possibly less toxic treatments for toxoplasmosis than currently available medicines
Feature Story: Will universities exist in 2067?
No full textThe presidents of the University of Regina, Campion College, First Nations University of Canada, and Luther College are pleased to present the 2017-18 Forward Together lecture, (Ex)Changing Ideas for Post-Secondary Education: Will Universities Exist in 2067. This stimulating conversation will be moderated by John Hopkins, CEO of the Regina and District Chamber of Commerce.Staffn
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