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Collectief organiseren : een sociaal-constructionistisch onderzoek naar het werken met grote groepen
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941-16 Beneficial Effects of OPC-18790 on Mechanoenergetics in Patients with Idiopathic Dilated Cardiomyopathy
No full textOPC–18790 is a novel inotropic agent which works partially by inhibiting phosphodiesterase without a positive chronotropic effect. The purpose of this study was to examine the effects of OPC–1 8790 on mechanoenergetics in patients with idiopathic dilated cardiomyopathy (DCM) in comparison with the effects of dobutamine. Twenty patients with DCM (LVEF<50%) received either OPC-18790 infusion (5–10μg/kg/min, n=10), or dobutamine (2.5–5μg/kg/min, n=10). Measurements of heart rate (HR), left ventricular enddiastolic volume index (LVEDVl), left ventricular end-systolic elastance (Ees), effective arterial elastance (Ea), myocardial oxygen consumption (MVO2), external work (EW). and pressure-volume area (PVA) were obtained by using conductance catheter and Webster catheter before and after administration of each drug.OPC-18790DobutaminebeforeafterbeforeafterHR(min-1)79±485±679±597±5***LVEDVI(mL/m2)126±11109±7**150±7141±11Ees(mmHg/mL)1.73±0.312.48±0.48*0.72±0.091.42±0.18***Ea(mmHg/mL)2.17±0.271.79±0.222.16±0.222.44±0.44MVO2(J/beat)4.51±0.663.61±0.62*516±0.747.27±1.30**EW(J/beat)0.70±0.060.65±0.100.90±0.111.09±0.13**EW/PVA(%)41.4±3.459.6±5.1**30.3±2.947.0±5.0***EW/MVO2(%)17.4±2.321.0±3.0*20.3±3.017.9±2.6*mean value±SEM*p<0.05**p<0.01***p<0.001 vs beforeOPC–18790 decreased MVO2and improved mechanical efficiency partially due to an adequate balance between inotropic and preload reducing effect. OPC-18790 may be useful for treating patients with congestive heart failure
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Direct Myocardial Effects of OPC-18790 in Human Heart Failure: Beneficial Effects on Contractile and Diastolic Function Demonstrated by Intracoronary Infusion With Pressure–Volume Analysis
No full textAbstractObjectives. We sought to determine the precise myocardial effects of OPC-18790 as demonstrated by intracoronary administration.Background. Although previous studies have determined the cardiovascular effects of a novel intravenous inotrope, OPC-18790, the observed benefits on contractile and diastolic function may have been confounded by the marked changes in peripheral loading associated with this drug when given intravenously.Methods. Eight heart failure patients received intracoronary OPC-18790 at 31.25 μg/min for 20 min, and then at 62.5 μg/min for another 20 min. Hemodynamic variables and pressure–volume indexes using the conductance catheter method were determined at baseline and then after the two doses.Results. There were no significant effects on heart rate, cardiac output or loading conditions, including afterload as determined by systemic vascular resistance and arterial elastance (Ea) and preload as determined by end-diastolic volume (EDV). There were significant increases in end-systolic elastance (Ees) from 0.74 ± 0.11 to 0.90 ± 0.16 mm Hg/ml at 31.25 μg/min and to 1.37 ± 0.33 mm Hg/ml at 62.5 μg/min (p < 0.05 by analysis of variance [ANOVA]). Diastolic function improved, as determined by the time constant for isovolumetric relaxation tau, which decreased significantly from baseline to 31.25 μg/min (94 ± 9 to 79 ± 9 ms, p < 0.05), and did not shorten further at 62.5 μg/min (78 ± 8 ms, p = NS). There were significant decreases in right atrial pressure (9 ± 1 to 7 ± 1 mm Hg, p < 0.01 by ANOVA) and mean pulmonary artery wedge pressure (21 ± 3 to 16 ± 2 mm Hg, p < 0.05 by ANOVA). This fall in filling pressures was not accompanied by any change in EDV. Inspection of the diastolic portion of the pressure–volume curve confirmed a downward shift consistent with pericardial release in five of the eight patients.Conclusions. Intracoronary administration of OPC-18790 demonstrates that the direct myocardial effects of this agent include a modest increase in inotropy and improvement in diastolic function, both of which occur without increases in heart rate, indicating that this agent may be beneficial for the intravenous treatment of congestive heart failure
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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