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Abstract 1341: Talin plays an important role in cell-cell interactions
No full textAbstract
Appropriate cell adhesion is necessary for numerous physiological processes and can be deranged in many diseases, including cancer. It has long been recognized that the cadherins mediated cell-cell adhesion receptor is an important determinant of tumor progression, serving as a suppressor of invasion and metastasis. Recently a role for the C-terminal region of talin (the VAD fragment) in cadherin mediated cell-cell attachment has been suggested, but its molecular mechanism remained unclear. Here, we identified a small region of the VAD fragment required for its localization to cadherin-mediated cell-cell junctions and also found that its localization to cell-cell junctions is independent of its actin binding properties. To identify the binding partner of the VAD fragment at cell-cell junctions we utilized immune-pulldown and found that it interacts with catenins, an important component of cadherin-mediated cell-cell junction. Based on our data, we proposed that the VAD-fragment of talin stabilized and/or stimulated the cell-cell junction by interacting with catenins.
Citation Format: Devang M. Patel, Akhilesh Kumar, William Morgan, Michael D. Birnbaum, Chaunhua Jiang, Fangliang Zhang. Talin plays an important role in cell-cell interactions [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1341. doi:10.1158/1538-7445.AM2017-1341</jats:p
IlluminierteUrkunden 1341-04-01_Lille
No full textCopie des lettres patentes de Philippe VI, roi de France ("Phelippes, par la Grace de Dieu, roys de France"), portant privilège des 17 articles relatifs à la juridiction de l’échevinage de Lille ("les eschevins, bourgois et habitans de nostre ville de Lille") après enquête de La Palu, seigneur de Varembon, gouverneur du baillage d’Amiens ("Pierre de la Palu, seigneur de Varembon, chevalier du roys, nostre seigneur, maistre des requestes de son hostel, gouverneur du baillage d’Amiens et des frontieres de Flandres"), suivant mandement y inséré du 29 janvier 1341.Archives et Jonathan Dumont
Stuart, Jesse Hilton, 1907-1984 (SC 1341)
Get PDFFinding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 1341. Letter, 1 October 1947, by Kentucky author, Jesse Stuart, Riverton, Kentucky, to Ann Cade, Morgantown, Kentucky. He relates that he has written ten books and suggests that she write his publisher about the availability of the books
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Acceso y servicio universal. De la Ley 1341 de 2009 a la Ley 1978 de 2019
No full textA propósito de la expedición de la Ley 1978 de 2019, Ley de modernización
del sector tic, el plan tic 2018-2022, el plan nacional conectividad, y la Ley
1341 de 2009, que recientemente cumplió una década, en este artículo se
analizan los diferentes aspectos normativos, de política pública y regulatorios
que han regido la universalidad del sector de las Tecnologías de la Información
y las Comunicaciones (tic), con la intención de estudiar su evolución
desde la Ley 1341, reconocer su entorno, la organización institucional, las
responsabilidades de los actores y, en general, los retos en relación con la
masificación de las tic y el cierre de la brecha digital
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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