1,734,623 research outputs found
MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4
No full textOsteosarcoma is the most prevalent primary bone malignancy in adolescents, and ferroptosis is implicated in its pathogenesis. MicroRNA (miR)-1287-5p plays critical roles in multiple human cancers, and the present study aims to investigate the role and underlying mechanisms of miR-1287-5p in regulating ferroptosis and osteosarcoma progression. Human osteosarcoma cell lines were treated with the mimic, inhibitor or matched controls of miR-1287-5p. Cell viability, colony formation, cell death ratio and ferroptosis were determined. miR-1287-5p expression was downregulated in human osteosarcoma, but upregulated upon ferroptotic stimulation. Overexpression of miR-1287-5p significantly induced, while inhibition of miR-1287-5p suppressed ferroptosis of osteosarcoma cells, thereby modulating cell viability and colony formation. Mechanistic studies indicated that miR-1287-5p directly bound to the 3′-untranslated region of glutathione peroxidase 4 (GPX4) to inhibit its protein level and activity, and that GPX4 overexpression completely abolished the miR-1287-5p mimic-mediated ferroptotic induction and tumor suppression. Moreover, the miR-1287-5p mimic dramatically sensitized human osteosarcoma cells to cisplatin chemotherapy. Our findings prove that miR-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4, identifying an adjuvant and even alternative method for the treatment of human osteosarcoma.</p
Resolución UNRN Nº 1287/2010. Crear la carrera Tecnicatura Universitaria en Procesos Agroindustriales
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN Nº 1287/2010. Crear la carrera Tecnicatura Universitaria en Procesos Agroindustriales, que otorgar el título de Técnico Universitario en Procesos Agroindustriales por la Universidad Nacional de Río Negrofals
Inscriptions 1280 à 1287
No full textInscriptions 1280 à 1287. In: Revue épigraphique, tome 4, N°93, 1899. pp. 17-22
Mullins, J H, 5/1287
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/428199Surname: Mullins. Given Name(s) or Initials: J H. Military Service Number or Last Known Location: 5/1287. Prisoner of War Enquiry Card Index Number: K.114. Division Enquiry: [No Division recorded]. Rank: PTE. Unit: Korea326955
Item: [2016.0049.60461] "Mullins, J H, 5/1287
Resolución UNRN Nº 1287 bis/2010. Modificar la Resolución UNRN Nº 856/2010.
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN Nº 1287 bis/2010. Modificar la Resolución UNRN Nº 856/2010 en lo relativo a la rectificación de la carga horaria de la asignatura Geografía y Recursos Económicosfals
SFB 1287 Data management plan
No full textThis is the data management plan for the collaborative research center (SFB 1287) at the University of Potsdam
Additional file 3: of MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors
Get PDFTable S2. Downregulated mRNAs after miR-1287 overexpression in the cell line SUM159. This list shows 126 mRNAs that were at least 1.5-fold downregulated with a p-value of<â0.05. (DOCX 18 kb
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