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Композиція фіточаю «Фіточай №6»
No full textПат. 12420 Україна, МПК7 А23F3/34. Композиція фіточаю «Фіточай №6» / В.М.Бречко, А.В.Головатий, С.В.Поспєлов, В.М.Самородов ; власник В.М.Бречко, А.В.Головатий, С.В.Поспєлов, В.М.Самородов. – № 200500765 ; заявл. 28.01.2005 ; опублік. 15.02.2006, Бюл. № 2. – 1 с.Розроблено композицію фіточаю, що містить чай зелений китайський байховий і траву ехінацеї, а також квітки ли серцелистої, траву звіробою звичайного та/або траву парила звичайного, квітки бузини чорної
Композиція фіточаю «Фіточай №6»
No full textПат. 12420 Україна, МПК7 А23F3/34. Композиція фіточаю «Фіточай №6» / В.М.Бречко, А.В.Головатий, С.В.Поспєлов, В.М.Самородов ; власник В.М.Бречко, А.В.Головатий, С.В.Поспєлов, В.М.Самородов. – № 200500765 ; заявл. 28.01.2005 ; опублік. 15.02.2006, Бюл. № 2. – 1 с.Розроблено композицію фіточаю, що містить чай зелений китайський байховий і траву ехінацеї, а також квітки ли серцелистої, траву звіробою звичайного та/або траву парила звичайного, квітки бузини чорної
Effect of CJ-12420, a novel potassium-competitive acid blocker, in gastric acid-related disease rat models
No full textCJ-12420, a novel potassium-competitive acid blocker (P-CAB), is a next generation therapeutics developed for the treatment of acid-related gastrointestinal diseases such as gastroesophageal reflux disease (GERD) and peptic ulcers. In the present study, the in vitro and in vivo pharmacological properties of CJ-12420 were compared with those of esomeprazole, a representative proton pump inhibitor. In vitro enzyme assays were performed using ion-leaky vesicles containing gastric H+/K+-ATPases isolated from pigs. The in vivo efficacies of CJ-12420 were evaluated in rat models of GERD and peptic ulcer. CJ-12420 inhibited the activity of porcine H+/K+-ATPase with an IC50 value of 0.53 μM in a reversible manner, whereas esomeprazole showed a weak and irreversible inhibition with an IC50 value of 42.52 μM. In a GERD model, CJ-12420 showed a dose-dependent efficacy in inhibiting esophageal injury and gastric acid secretion with an ED50 of 2.0 mg/kg, which was 15-fold more potent than that of esomeprazole. In peptic ulcer models, CJ-12420 exhibited superior antiulcer activity compared to esomeprazole. The ED50 of CJ-12420 in the naproxen-, ethanol-, and water-immersion restraint stress-induced peptic ulcer models were 0.1, 1.4, and 0.1 mg/kg, respectively. In the acetic acid-induced peptic ulcer model, the curative ratio of CJ-12420 at 10 mg/kg was higher than that of esomeprazole at 30 mg/kg (44.2% vs. 32.7%, respectively), after 5 days of repeated oral administration. Thus, CJ-12420 is a novel P-CAB that shows potent and reversible inhibition of gastric H+/K+-ATPase and may provide stronger efficacy compared with previous proton pump inhibitors.신규 기전인 칼륨 경쟁적 위산분비 저해제 (P-CAB)인, CJ-12420은 위식도 역류성 질환과 위십이지장궤양과 같은 위산관련 질환의 치료를 위해 개발하고 있는 차세대 치료제이다. 본 연구에서는, CJ-12420의 in vitro와 in vivo 약리학적 특성을 대표적 양성자 펌프 저해제인 에스오메프라졸과 비교 평가해 보았다. In vitro 효소활성 평가는 돼지의 위장에서 분리한 위 H+/K+-ATPase를 이용하여 수행하였고, 동물모델은 랫드를 이용한 위식도 역류질환모델과 위십이지장모델에서 수행하였다. CJ-12420은 가역적으로 H+/K+-ATPase를 억제하였고 IC50값은 0.53 uM이었다. 반면, 에스오메프라졸은 비가역적이면서 IC50값도 42.52 uM로 활성이 떨어짐을 확인하였다. 위식도역류질환 랫드모델에서, CJ-12420은 용량상관적으로 위식도 손상을 억제하였고, ED50값이 2.0 mg/kg으로 에스오메프라졸보다 약 15배 강한 위산분비억제능을 보여주었다. 다양한 위십이지장 랫드모델에서, CJ12420은 에스오메프라졸보다 강력한 항궤양 효능을 보여주었으며, 나프록센모델-, 에탄올모델-, 그리고 구속수침모델에서의 ED50값은 각 0.1, 1.4, 그리고 0.1 mg/kg이었다. 아세트산 유도 위궤양 랫드모델에서도, 5일간 반복투여 후 CJ-12420은 에스오메프라졸보다 항궤양 치유율이 우월하였다. (44.2% vs. 32.7%). 이와 같이, CJ-12420은 위산분비 펌프를 강력하고 가역적으로 억제할 수 있는 신규 P-CAB기전의 약물로서, 이전 양성자 펌프 저해제와 비교하여 우월한 효능을 제공해 줄 수 있을 것으로 기대된다.Table of Contents
Abstract 1
Table of Contents 2
I. Introduction 1
II. Materials and Method 5
III. Results 13
IV. Discussion 36
References 41
국문요약 46Docto
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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